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A study shows that 'mosaicism' is gaining ground in cancer research
Date:6/12/2012

ed by the CNIO group, show that these mutations, which are confined solely to the cells of the affected skin and, as congenital conditions, arise during embryonic development, are the genetic cause of these anomalies and predispose to the formation of tumours.

Analysing the genome of 57,000 people

A complete analysis of the genome of over 57,000 individuals, also published this week in Nature Genetics, lends weight to the theory that mosaicism of distant origin is more widely present in patients with tumours than cancer-free individuals.

This second study drew on the combined efforts of 189 researchers worldwide, including Francisco X. Real and fellow CNIO researcher Nria Malats, head of the Genetic and Molecular Epidemiology Group, under the leadership of scientists at the U.S. National Cancer Institute and Pompeu Fabra University in Barcelona.

It is from this variability in the genetic makeup of cells from the same individual that we get the idea of personal genomes, in the plural. "Some of these mutations imply an increased risk of cancer, so certain patients should have more frequent examination to check how their lesions are progressing," explains Real.


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Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

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