Navigation Links
A study shows that 'mosaicism' is gaining ground in cancer research
Date:6/12/2012

A study recently published in Nature Genetics provides new evidence that the genetic makeup of the embryo may cause the appearance of tumors in adult life. These results bear out the growing theory that some tumors may have an extremely early origin, tracing to the individual's embryonic development, while offering new clues to understand the genetic causes of certain kinds of cancer, and their prevention and treatment.

Researcher Francisco X. Real, head of the Epithelial Carcinogenesis Group at the Spanish National Cancer Research Centre (CNIO) took part in the study, which was led by Christian Hafner of the University of Regensburg, Germany.

A cell, when it divides, generates two other identical cells with the same characteristics and genetic material. Genetic mutations alterations in the genes can occur during the embryo's development, and will then be passed to the daughter cells in the division process. The result is an individual whose cells differ genetically. It has long been suspected that this phenomenon, known as mosaicism, could be linked to several types of cancer, but the scientific community has little information on the genetic alterations that underlie it.

The authors of the paper conducted an exhaustive genetic study of 67 patients with a number of congenital skin lesions leading to tumours (nevus sebaceous, NS). They also studied the Schimmelpenning syndrome (SS), in which tissues like the brain or eye are also affected.

Biopsies of these patients' lesions found for the first time mutations in genes of the RAS family (97% in cases of NS and 100% in SS) which encode proteins of key importance in cell division regulation, while analyses of lesion-free tissues, like cells of the mouth mucous, blood leukocytes, etc. found their gene sequence to be normal. Further, all the patients that developed tumours were also mosaic for this gene family.

The above results, and those of previous studies led by the CNIO group, show that these mutations, which are confined solely to the cells of the affected skin and, as congenital conditions, arise during embryonic development, are the genetic cause of these anomalies and predispose to the formation of tumours.

Analysing the genome of 57,000 people

A complete analysis of the genome of over 57,000 individuals, also published this week in Nature Genetics, lends weight to the theory that mosaicism of distant origin is more widely present in patients with tumours than cancer-free individuals.

This second study drew on the combined efforts of 189 researchers worldwide, including Francisco X. Real and fellow CNIO researcher Nria Malats, head of the Genetic and Molecular Epidemiology Group, under the leadership of scientists at the U.S. National Cancer Institute and Pompeu Fabra University in Barcelona.

It is from this variability in the genetic makeup of cells from the same individual that we get the idea of personal genomes, in the plural. "Some of these mutations imply an increased risk of cancer, so certain patients should have more frequent examination to check how their lesions are progressing," explains Real.


'/>"/>

Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Sleep apnea persisting into teens can impact life skills, study finds
2. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
3. Docs Arent Coaching Overweight Kids on How to Slim Down: Study
4. Study sheds new light on role of genetic mutations in colon cancer development
5. Two-Thirds of Osteo Hip Fractures Occur After 80: U.S. Study
6. Study links teamwork, communication with quality of nursing home care
7. HIV superinfection in Uganda may be more common than previously thought, study finds
8. Many Kids on Medicaid Dont See Dentist: Study
9. Reach2HD, a Phase II study in Huntingtons disease, launched
10. Belly Membrane May Regulate Immune System, Mouse Study Finds
11. Skin Cells Turned Into Brain Cells in Lab Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Donor ... and Nevada and LABS, Inc., announced the future opening of a CLIA certified ... and serology testing used to determine the suitability of potential organ and ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... solution provider, today announced that its digital marketing solutions have enabled Children’s Hospital ... investment in 24 months. , Recognizing the value of a digital marketing ...
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren Smith, ... to accept new patients in need of skilled pediatric dentistry in Rock ... Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in a ...
(Date:3/22/2017)... Milford, PA (PRWEB) , ... March 22, 2017 , ... ... producers, according to a US Department of Agriculture report. While excess dairy can ... sensitivity play a role. Lactose sensitivity is the inability to properly digest lactose, a ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... financial consultations to families and business owners in the greater Hampton Roads area, ... American Cancer Society Relay For Life event. , Each year, hundreds of people ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , 22. März 2017   ... und weltweit tätige Anbieter von Produkten und ... den Erwerb von EPL Archives Inc. bekannt, ... der Kunden im kompletten Zyklus regulierter Forschung, ... von Proben, Speicherung von Dokumenten und Zusatzdienstleistungen ...
(Date:3/22/2017)... 2017 TapImmune, Inc. (NASDAQ: ... development of innovative peptide and gene-based immunotherapeutics for ... announced that it will participate in two upcoming ... Glynn Wilson , Chairman and CEO of TapImmune, ... clinical pipeline and partnering opportunities for its proprietary ...
(Date:3/22/2017)... 22, 2017 A new independent study ... the proven ultraviolet-C (UV-C) disinfection solution of choice ... Published in the March issue ... , the peer-reviewed study of UV-C disinfection systems ... General Hospital and Rochester General Hospital. According to ...
Breaking Medicine Technology: