Navigation Links
A study led by CNIO validates a new anti-cancer therapy based on cell division
Date:11/18/2013

Aurora-A is a protein involved in the cell division process that is highly expressed or synthesised in a large number of human cancers, especially in those associated with a bad prognosis. Several pharmaceutical companies have recently developed these protein inhibitors, although the therapeutic and physiological effects that blocking Aurora-A might have on adult tissues are still unknown.

A study led by Ignacio Pérez de Castro, a researcher in the Spanish National Cancer Research Centre's (CNIO) Cell Division and Cancer Group, and its Group Leader, Marcos Malumbres, describes the cellular consequences of genetically deleting Aurora-A, an important target for the development of new anti-cancer agents, in mouse models. The work, which was carried out in collaboration with researchers Terry Van Dyke and Dale Cowley, from North Carolina University in the US, is published today in Cancer Research, the most cited cancer journal.

AURORA-A, AGEING AND CANCER

Aurora-A is a protein involved in the regulation of the cell cycle, a process by which cells reproduce and form tissues. Although these elementary functions had been widely studied in several model organisms and mouse embryos, their role in tissues and adult organisms remained unknown.

Using genetically engineered Aurora-A deficient mice, the authors of the study have discovered that the absence of this protein causes an increase in the number of cells with a high DNA content; this is a consequence of an aberrant distribution of the genetic material upon division.

"This phenomenon causes defects in cell proliferation, as well as an increase in the number of dead and senescent cells, which triggers premature ageing in the animals studied", says Ignacio Pérez de Castro. The researcher adds that: "In those mice, we also see an increase in DNA damage and, most importantly, a reduction in the progression of skin and breast tumours".

The study helps to solve two of the great limitations pharmaceutical companies find themselves up against when they carry out clinical trials with Aurora protein inhibitors. Firstly, the compounds used in clinical trials are not completely specific and are not capable of adequately discriminating between the three members of the Aurora family: Aurora- A, B or C. Mice generated by CNIO confirm the therapeutic value of the first member of this family of proteins.

"Secondly, clinical studies with these inhibitors have surveillance problems as a result of the lack of markers that allow monitoring their effects on the cells", says Marcos Malumbres. The researchers propose studying the volume of the cell nucleus, a consequence of a change in DNA content, as a new tool for evaluating the efficiency of these new anti-cancer drugs.

Given that Aurora-A inhibition damages DNA, Malumbres's team says that the use of Aurora-A inhibiting drugs could sensitise tumours to anti-cancer agents that are currently in clinical use and attack cells causing high levels of DNA damage.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Influence of pro-smoking media messages lasts 7 days, study finds
2. Study compares outcomes of device for chest compressions vs manual CPR
3. Study examines effectiveness, safety of transcatheter aortic valve replacement in US
4. New Study Reports on the High Cost of Cardiac Surgery Healthcare Associated Infections
5. Narconon Arrowhead Provides Bible Study Classes
6. Study Highlights Challenges for Individuals with Lung Cancer, Allsup Reports
7. Study unveils SINEs potential of re-activating tumor fighting proteins within a cell
8. Italian study examines clinical predictors of acute urinary symptoms after radiotherapy for prostate
9. Multicenter study underscored the need of a uniform approach to the treatment of BCa
10. Regenstrief and IU study: Older adults with severe mental illness challenge healthcare system
11. Workers’ Compensation Costs Per Claim Moderating In Pennsylvania After Years of Growth, New Study Reports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... , ... MelaKids, a Laredo-based company, has introduced a new concept for children’s ... gives us a full supply of melanin – in the back of the eye ... pigment; however, around the age of thirty, we develop a yellow-brown pigment in the ...
(Date:9/19/2017)... , ... September 19, 2017 , ... The Workgroup ... of health IT to create efficiencies in healthcare information exchange and a trusted advisor ... of their latest industry white paper, entitled Barriers to Adoption of the ERA ...
(Date:9/19/2017)... ... ... Public outrage over the toxins that exist in tap water and the lack ... itself to research, develop and ultimately supply consumers with healthy drinking water alternatives. Vitev ... alkaline water technologies, water filtration systems, and consumer education. , ...
(Date:9/19/2017)... ... September 19, 2017 , ... Bone Solutions Inc. (BSI), an ... orthopedic medical device, OsteoCrete®. OsteoCrete® bone void filler is designed to assist with ... magnesium, a critical property for bone health and development. , “We’re excited to ...
(Date:9/19/2017)... ... September 19, 2017 , ... Ron Norman, CEO of Team Decades, ... of making a distinct rather than generic impression in the job market if one ... a stack of resumes knows that the first impression they give off is not ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... Sept. 6, 2017   PDI , a leader in ... host an educational session focused on the role of ... prevention at the 2017 Annual Scientific Meeting of the ... place at the Phoenix Convention ... Sept. 16-19, will also feature PDI,s Prevantics® Device ...
(Date:9/6/2017)... 2017 Eli Lilly and Company (NYSE: ... data for galcanezumab and lasmiditan, two investigational treatments for ... Society (IHC) taking place Sept. 7-10 in ... new, long-term data from an open-label study evaluating the ... mg and 240 mg) for the prevention of migraine. ...
(Date:9/5/2017)... NEWTOWN, Pa. , Sept. 5, 2017  Xyntek Inc. has announced another ... opened a new Midwest office to meet the growing demands of customer engagements ... Xyntek's new Midwest office is located at ... ... demands of customer engagements regionally. ...
Breaking Medicine Technology: