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A stem cell type supposed to be crucial for angiogenesis and cancer growth does not exist?
Date:4/22/2008

in large numbers of BM derived cells such as ordinary white blood cells that often are very close to blood vessel walls, and may therefore have been misinterpreted as blood vessel wall ECs in earlier studies utilizing less advanced technologies.

The results have great practical significance when researchers are trying to focus on novel approaches to cure cancer by targeting the normal cells of the body which supply tumors with blood and nutrients. "Our results will help the researchers to concentrate their efforts on molecular and cellular targets that actually exist" says Dr. Salvn, leader of the Helsinki team.

"It has been a learning experience to try to publish results that demonstrate that a number of fellow research have for years been studying nonexistent cells", Dr. Salven comments. "Issues concerning publication bias and nonaccessibility of negative data are really becoming more and more relevant, just as recently seen also in other fields of biomedicine."


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Contact: Dr. Petri Salvn
petri.salven@helsinki.fi
358-505-645-457
University of Helsinki
Source:Eurekalert

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