Navigation Links
A stem cell type supposed to be crucial for angiogenesis and cancer growth does not exist?

Angiogenesis, the growth of new blood vessels, is a central process in diverse physiological and pathological situations such as healing of wounds and traumas, cardiovascular disorders, inflammatory conditions such as rheumatoid arthritis, and in cancer growth. The current belief about the source of blood vessel wall endothelial cells (ECs) responsible for vascular growth in adults is that a significant and crucial part of neovascular ECs originate from circulating stem and progenitor cells that are first mobilized from the bone marrow (BM), and subsequently differentiate to mature bona fide ECs and incorporate in the vasculature. This concept has become textbook material, and a common theme in modem vascular and cancer biology.

Importantly, it is widely believed that tumor angiogenesis and cancer growth critically depend on BM derived circulating endothelial precursor cells. Endothelial precursors would thus provide a powerful novel approach to block tumor angiogenesis and cure cancer. Correspondingly, therapeutic transplantation of such stem cells would be a promising approach to restore tissue vascularization after ischemic events. Clinical trials with human patients are currently ongoing based on the circulating endothelial precursor cell dogma.

Now, researchers lead by Dr. Petri Salvn at the University of Helsinki, Finland, and the stem cell research pioneer Dr. Irving Weissman at Stanford University, California, have shown that circulating endothelial precursor cells actually do not exist, and that angiogenesis and cancer growth do not involve or depend on such hypothetical stem cells. (PNAS, in press; online 21.-25.4.). By using endothelial cell specific genomic mouse models and most modern three dimensional cellular imaging technologies, they show that endothelial differentiation is not a typical function of BM derived stem cells, and it has to be an extremely rare event if it occurs at all. However, angiogenic and tumor tissues contain large numbers of BM derived cells such as ordinary white blood cells that often are very close to blood vessel walls, and may therefore have been misinterpreted as blood vessel wall ECs in earlier studies utilizing less advanced technologies.

The results have great practical significance when researchers are trying to focus on novel approaches to cure cancer by targeting the normal cells of the body which supply tumors with blood and nutrients. "Our results will help the researchers to concentrate their efforts on molecular and cellular targets that actually exist" says Dr. Salvn, leader of the Helsinki team.

"It has been a learning experience to try to publish results that demonstrate that a number of fellow research have for years been studying nonexistent cells", Dr. Salven comments. "Issues concerning publication bias and nonaccessibility of negative data are really becoming more and more relevant, just as recently seen also in other fields of biomedicine."


Contact: Dr. Petri Salvn
University of Helsinki

Related medicine news :

1. Renowned Doctor Says Best Way to Obtain Crucial Vitamin D Is From Sun; but Still, Dont Forget Sunscreen
2. The Leukemia & Lymphoma Society Offers Crucial Help at a Critical Time
3. 2 genes found to play crucial role in cell survival
4. AHF Says Op-Out Clause is Crucial to New Jersey Law Requiring HIV Testing of Pregnant Women
5. Molecular pathway appears crucial in development of pulmonary fibrosis
6. Committee to Reduce Infection Deaths Applauds Senator Durbins Hospital Infection Legislation, but Suggests Some Crucial Additions in Order to Combat Soaring MRSA Rates
7. Is a good nights sleep crucial for your health?
8. Cities Say Restaurant Nutrition Information Crucial in Fighting Obesity
9. Childrens Hospital Boston Mourns the Death of Dr. Judah Folkman, World Renowned Researcher and Founder of the Field of Angiogenesis
10. Pathway links inflammation, angiogenesis and breast cancer
11. Potential viral therapy weapon for difficult cancers is safe and effective in study
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort to ... to access life-saving information provided directly from top experts in mesothelioma, in 2016 ... conferences in three major cities: Houston, San Francisco, and Chicago. , “For ...
(Date:11/30/2015)... Los Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... hunger cravings that drive people to overeat are not necessarily caused by real hunger, ... brain that the stomach needs food. He notes that, while many patients are aware ...
(Date:11/30/2015)... FL (PRWEB) , ... November 30, 2015 , ... ... a comparison chart and ingredient list of its hemorrhoid ointment to its website. ... effective pain relief for people suffering from hemorrhoids. Adding the comparison chart and ...
(Date:11/30/2015)... ... November 30, 2015 , ... Using a combination of two blood sugar tests ... adults, according to a new study by researchers at the School of Public Health ... Adults: Using Combinations of Blood Glucose Tests ,” published in Frontiers in Public Health, ...
(Date:11/30/2015)... ... November 30, 2015 , ... The recently published 32nd Annual ... (NPDS) reveals that in 2014, someone called a poison center about every 11 ... which were human exposure cases. , The American Association of Poison Control Centers ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 iCAD, Inc. (Nasdaq: ICAD ... latest solutions for advanced image analysis and workflow ... the Radiological Society of North American (RSNA) 2015 ... from November 29 to December 4, 2015. The ... an automated breast density assessment solution, PowerLook® Advanced ...
(Date:11/30/2015)... , Nov. 30, 2015 Booth #4303 – The ... ) will exhibit a broader array of products in a ... Society of North America in ... the meeting will feature X-ray components "At the Heart of ... line of products from Varian,s Claymount brand, and computer-aided diagnostic ...
(Date:11/30/2015)... , Nov. 30, 2015  Novartis will demonstrate the ... 57 th American Society of Hematology (ASH) Annual ... myelomas as well as supportive care, including key findings ... personalized cell therapies. The ASH Annual Meeting will be ... . Novartis Oncology . "We will be ...
Breaking Medicine Technology: