Navigation Links
A smoking gun in lung cancer epigenetics
Date:2/15/2013

Recent studies have identified correlations between cigarette smoke-induced microRNA (miRNA) expression and different aspects of lung cancer; however, it is unclear how miRNA expression directly contributes to carcinogenesis. MiRNAs regulate the expression of target genes and can have a significant impact on when and how well different gene products are expressed. In this issue of the Journal of Clinical Investigation, David Schrump and colleagues at the National Cancer Institute in Bethesda, MD, measured miRNA expression in normal human lung cells exposed to cigarette smoke condensate (CSC) and lung cancer cells derived from smokers and non-smokers. They found that CSC exposure repressed the miRNA miR-487b. Loss of miR-487b increased the expression of several oncogenes and enhanced the proliferation, invasion, tumorigenicity, and metastatic capacity lung cells. Loss of miR-487b and concomitant up-regulation of the five oncogenes was also observed in patient lung cancer specimens. These results reveal a direct mechanism by which cigarette smoke-induced miRNA alterations promote lung carcinogenesis.


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Anti-tobacco TV ads help adults stop smoking, study finds
2. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
3. Small neural focus groups predict anti-smoking ad success
4. Some women may be genetically predisposed to smoking-related hot flashes
5. Friends Parents Can Sway Teens Odds for Drinking, Smoking
6. Fewer Young Americans Smoking, Survey Finds
7. Vitamin C improves pulmonary function in newborns of pregnant smoking women
8. Genetic marker may predict smoking quantity in African Americans
9. 5 percent of workers gave up smoking when the anti-tobacco law took effect
10. Vitamin C improves lung function in newborns of pregnant smoking women
11. States Use Only Fraction of Tobacco Revenues to Fight Smoking, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... PureLife Dental is pleased to announce that California ... members. As part of the amalgam separator endorsement, all CDA members may purchase an ... off the retail value. This partnership between PureLife and CDA is especially timely as ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... Ulster University, ... June, 2017 from 9 am to 3 pm to present to graduate students exciting ... is an original curriculum project led by The Health Improvement Service of the ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency ... throughout eastern Texas, is announcing the launch of a new charity drive to benefit ... in the United States reveal that an estimated 252, 710 new cases of invasive ...
(Date:6/22/2017)... , ... June 22, 2017 , ... Branches, Inc. has ... than $245,000 in grant funding to support its programs focused on providing opportunity to ... was awarded a grant by the Foundation of $15,000 to support its , Climb ...
(Date:6/22/2017)... ... ... Groove Ring is excited to announce they've partnered with Olympic runner Jared ... all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the great ... the rock face to the auto shop, Groove Ring is the world's first breathable ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... 14, 2017 The Bio Supply Management Alliance ... of Fremont and the Biomedical Manufacturing Network ... in California by providing a ... and fostering workforce development. The primary focus of this ... start-ups, as well as small and mid-sized biomedical companies. ...
(Date:6/13/2017)... June 13, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that the U.S. Food and Drug Administration (FDA) has ... 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter related ... facility is a measure of the progress we have made ...
(Date:6/11/2017)... , June 10, 2017  Eli Lilly and Company (NYSE: ... three Phase 3 studies of galcanezumab, an investigational treatment ... late-breaking data on several key secondary endpoints for galcanezumab ... from these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be ... scientific meeting in Boston . ...
Breaking Medicine Technology: