Navigation Links
A single protein regulates 2 immune pathways
Date:4/29/2010

HOUSTON (April 29, 2010) Unchecked, the natural or innate immune system can run out of control like a stuck accelerator on a car. Eventually, it will kill the host it is supposed to protect.

Much scientific attention is directed at understanding how this innate immune system is turned on, but little to how it is cooled down or regulated. That is important because the innate immune system is associated with inflammation. In turn, unchecked inflammation is associated with cancer, heart disease, autoimmune diseases and other chronic ailments.

A team of researchers led by Baylor College of Medicine has identified a protein called NLRC5, a member of the NOD-like protein family, that is involved in inhibition of protein complexes key to critical pathways of innate immunity called NF-κB and type I interferon signaling. A report on their work appears in the current issue of the journal Cell.

"Understanding the molecular mechanisms that hold innate immunity in check could provide clues to better treatments for cancer and autoimmune diseases associated with inflammation," said Dr. Rong-Fu Wang, professor in the Center for Cell and Gene Therapy, the department of pathology and immunology at BCM and a senior author of the report.

Think of the innate immune system as a rushing cascade, blocked in places by chunks of rock or landscape and forced through natural cavities in a particular direction. Protein complexes such as the protein IKK complex in NF-κB pathway, and RIG-I and MDA5 as pathogen sensors in type I interferon pathways, act like these natural forces to control and direct the cascade of events that result in innate immunity.

NLRC5 interacts with two subunits of IKK to prevent their activation through blocking addition of a phosphate molecule (phosphorylation). This in turn, inhibits NF-κB activation and innate immune responses. NLCRC5 also interacts with innate immune receptors RIG-I and MDA5
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cooking For Bachelors Seeks Singles Cooking For Love
2. SILS -- A New Houston Weight Loss Surgery -- Single Incision Laparoscopic Surgery
3. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
4. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
5. East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program
6. Single Shot of H1N1 Vaccine May Be Enough for Kids
7. Single gene mutation induces endometrial cancer
8. Bone-anchored hearing aids help youth with single-sided deafness
9. Device Helps Kids With Single-Sided Deafness
10. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
11. Theory of single stem cell for blood components challenged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Tysons, VA (PRWEB) July 14, 2014 ... been a local icon to the Tysons Corner skyline ... Corner becoming its own municipality, known simply as “Tysons”, ... Sheraton Tysons Hotel. In addition to Tysons becoming ... Stations located in the heart of Tysons brings an ...
(Date:7/14/2014)... TX (PRWEB) July 14, 2014 Kenn Renner ... recently. The video is meant to describe the business on ... estate broker and national speaker – Kenn Renner – is ... branding, marketing, and goal setting techniques. , Investing in real ... money. Some people do it as their career, while others ...
(Date:7/14/2014)... 2014 Dry eyes, contrary to popular opinion, ... recent research have pointed out, today’s technology has practically enabled ... as a result of using laptops and smartphones to ... Because of this phenomenon, it has become imperative for people ... cure them from having dry eyes, but prevent it from ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 The Cabin ... launched its new Alumni Community website – ... treatment, to help them maintain lifelong recovery wherever they ... that providing clients the tools to help them maintain ... and essential part of any reputable treatment programme. As ...
(Date:7/14/2014)... July 14, 2014 EurekaMag.com has newly ... which is a contagious liver disease that ranges ... weeks to a serious, lifelong illness that attacks the ... States have chronic Hepatitis C virus infection of which ... site's research category covers all studies on Hepatitis ...
Breaking Medicine News(10 mins):Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 3Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 4Health News:Dry Eye Handbook Review | Taking Care of One’s Vision by Using Natural Methods – Vinamy.com 2Health News:Dry Eye Handbook Review | Taking Care of One’s Vision by Using Natural Methods – Vinamy.com 3Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 2Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 3Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2
... off from certain osteoporosis drugs may be beneficial to bone ... System. Researchers found that bone density remained stable for three ... a popular class of osteoporosis drugs that can cause fractures ... bone. "These drugs are potentially harmful when taken for ...
... By Randy Dotinga HealthDay Reporter , THURSDAY, Nov. ... evidence that people infected with HIV, the virus that causes ... other patients when they undergo kidney transplants. Up until ... HIV patients because of fear that AIDS would quickly kill ...
... Johns Hopkins have identified a compound that could be ... The compound, called a glutaminase inhibitor, has been ... scientists say, may have the potential to be used ... Johns Hopkins scientists, are inventors on patent applications related ...
... NC Researchers have been stymied for years over the ... produce antibodies in response to the pathogen antibodies that ... at Duke University Medical Center can explain why: Some of ... can,t actually "see" the virus until after it,s already invaded ...
... THURSDAY, Nov. 18 (HealthDay News) -- Millions of harried ... indoor smoking at one in every four major U.S. ... smoke-free policies at large-hub airports in 2002 and 2010 ... nation,s largest airports, including three of the five busiest: ...
... Reinberg HealthDay Reporter , WEDNESDAY, Nov. 17 (HealthDay ... example, new research finds that doctors, prescribing patterns vary across ... U.S. Food and Drug Administration. The result is ... depending on where they live, the researchers said. "We ...
Cached Medicine News:Health News:Taking a break from osteoporosis drugs can protect bones 2Health News:HIV Patients Do Well After Kidney Transplants: Study 2Health News:HIV Patients Do Well After Kidney Transplants: Study 3Health News:Compound that blocks sugar pathway slows cancer cell growth 2Health News:Compound that blocks sugar pathway slows cancer cell growth 3Health News:Why so many antibodies fail to protect against HIV infection 2Health News:Smoking Still Allowed at 1 in 4 Major U.S. Airports 2Health News:Despite FDA Warning, Avandia Use Varies Across U.S. 2Health News:Despite FDA Warning, Avandia Use Varies Across U.S. 3
(Date:7/14/2014)... Lumin Medical LLC, a healthcare IT provider, ... leading provider of on-demand patient tracking solutions and is ... to Franklin, Wis. ... and our mission is to provide visibility for the ... reduce costs," said James Hermann , President of ...
(Date:7/14/2014)... DIEGO , July 14, 2014  More than any ... their smartphones and tablet computers -- but their eyes don,t. ... have never needed before, and the eye has not evolved ... and what our eyes can do comfortably often results in ... collectively known as Digital Eye Strain. Now ZEISS has invented ...
(Date:7/14/2014)... EAGAN, Minn. , July 14, 2014  Today, ... Partners, announced that it acquired the assets of MicroTest ... MA.  The acquisition of MTL is the first step ... and chemistry laboratory services platform to support the medical ... be known as Accuratus Lab Services , a ...
Breaking Medicine Technology:Lumin Medical Purchases PatientTrak 2Lumin Medical Purchases PatientTrak 3New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 2New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 3ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 2ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 3
... III Study for the Treatment of Advanced Prostate CancerPARSIPPANY, ... launch of a Phase IIIB clinical trial of degarelix ... antagonist approved by the U.S. Food and Drug Administration ... cancer. The announcement was made at ...
... Diagnostic ToolSUNNYVALE, Calif., April 27 Cepheid (Nasdaq: ... MTB/RIF as a CE IVD Mark product under the ... Devices. For the first time, European clinicians will have ... Mycobacterium tuberculosis (MTB) and resistance to rifampicin ...
Cached Medicine Technology:Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy 2Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy 3Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy 4Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy 5Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin 2Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin 3Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin 4Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin 5Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin 6
... a low osmolar ionic dimer. Each ... meglumine, 196 mg of ioxaglate sodium ... disodium as a stabilizer. The solution ... each milliliter and provides 32% (320 ...
... IMAGOPAQUE is a non-ionic monomeric contrast ... in adults and children. After a decade ... 3.5 million examinations, IMAGOPAQUE has proven to ... effort in hundreds of radiology departments.Results from ...
... is a liver-specific contrast agent approved for ... Its introduction expands the Amersham Health portfolio ... injected intravenously, TESLASCAN aids in the detection, ... Imaging can begin within minutes of injection, ...
... a new Contrast Agent for ... of stabilized SF6 microbubbles. The ... between 1 and 10 m, ... 2 and 5 x 108 ...
Medicine Products: