Navigation Links
A single protein regulates 2 immune pathways
Date:4/29/2010

HOUSTON (April 29, 2010) Unchecked, the natural or innate immune system can run out of control like a stuck accelerator on a car. Eventually, it will kill the host it is supposed to protect.

Much scientific attention is directed at understanding how this innate immune system is turned on, but little to how it is cooled down or regulated. That is important because the innate immune system is associated with inflammation. In turn, unchecked inflammation is associated with cancer, heart disease, autoimmune diseases and other chronic ailments.

A team of researchers led by Baylor College of Medicine has identified a protein called NLRC5, a member of the NOD-like protein family, that is involved in inhibition of protein complexes key to critical pathways of innate immunity called NF-κB and type I interferon signaling. A report on their work appears in the current issue of the journal Cell.

"Understanding the molecular mechanisms that hold innate immunity in check could provide clues to better treatments for cancer and autoimmune diseases associated with inflammation," said Dr. Rong-Fu Wang, professor in the Center for Cell and Gene Therapy, the department of pathology and immunology at BCM and a senior author of the report.

Think of the innate immune system as a rushing cascade, blocked in places by chunks of rock or landscape and forced through natural cavities in a particular direction. Protein complexes such as the protein IKK complex in NF-κB pathway, and RIG-I and MDA5 as pathogen sensors in type I interferon pathways, act like these natural forces to control and direct the cascade of events that result in innate immunity.

NLRC5 interacts with two subunits of IKK to prevent their activation through blocking addition of a phosphate molecule (phosphorylation). This in turn, inhibits NF-κB activation and innate immune responses. NLCRC5 also interacts with innate immune receptors RIG-I and MDA5 to block type I interferon response.

When Wang and his colleagues "knocked down" or reduced the amount of the NLRC5 protein, both NF-κB and type 1 interferon activity increased, resulting in increased innate immune responses and antiviral immunity.

"Our findings identify NLRC5 as a key negative regulator that blocks two central components of the NF-κB and type I interferon pathways," said Wang. That makes it a key element in keeping the innate immune system running at just the right level.


'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related medicine news :

1. Cooking For Bachelors Seeks Singles Cooking For Love
2. SILS -- A New Houston Weight Loss Surgery -- Single Incision Laparoscopic Surgery
3. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
4. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
5. East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program
6. Single Shot of H1N1 Vaccine May Be Enough for Kids
7. Single gene mutation induces endometrial cancer
8. Bone-anchored hearing aids help youth with single-sided deafness
9. Device Helps Kids With Single-Sided Deafness
10. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
11. Theory of single stem cell for blood components challenged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... FL (PRWEB) , ... January 20, 2017 , ... Doctor ... announced it attended the January ECRM trade show to continue the marketing and distribution ... vitamin C supplement, known for providing 400 percent better absorption than traditional vitamin C ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... Michael and ... Dana Farber Cancer Institute. For Betsy, the clinical trial has been life-saving as ... has not worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following ... Chocolate Biscuit” is the creation of published author, Marlyn Ivey, born in Lynn Haven, Florida ... went to school and at 19 years of age, he joined the Navy and got ...
(Date:1/20/2017)... ... ... is God’s Lighthouse”: a moving and colorful collection of prayers that reminds readers ... author, Gene Gaapf, a retired truck driver, and a long-time writer, whose published works ... school and have many different titles,” Gaapf mentions about his different works. “I am ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Next week after ... be repealed by Congressional political games that circumvent health needs of over 30 million. ... capture the human anxieties and needs government public servants were suppose to prioritize. Interviews ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 19, 2017 According to ... for cryotherapy is set to witness a CAGR of 6.5% during ... America will continue to be the leading market for ... ... Suppliers are emphasizing on ensuring affordable and adequate supply of gas ...
(Date:1/19/2017)... Jan. 19, 2017 ViewRay, Inc. (Nasdaq: VRAY) announced ... institution supporting research in Germany , ... treatments at the University Clinic Heidelberg as part of ... MRIdian Linac program will be headed by Medical Director ... radiation oncology at the German Cancer Research Center (DKFZ), ...
(Date:1/19/2017)... BEACH, Florida , January 19, 2017 /PRNewswire/ ... incoming Trump administration appears serious about reducing the ... advancements and innovation in the medical drug industry, ... forge ahead with new clinical trials and development ... Pharma companies forging ahead with recent developments include:  ...
Breaking Medicine Technology: