Navigation Links
A single protein helps the body keep watch over the Epstein-Barr virus
Date:2/17/2012

Boston, Mass. Some 90 percent of people are exposed to the Epstein Barr virus (EBV) at some point in their life. Even though it is quickly cleared from the body, the virus can linger silently for years in small numbers of infected B cells. According to researchers at Children's Hospital Boston and the Immune Disease Institute (IDI), the immune system subdues the virus by watching for a single viral protein called LMP1, knowledge that has already helped suggest two new treatments for the EBV-fueled cancers seen in some immunosuppressed patients.

The study team, led by Klaus Rajewksy, MD, and Baochun Zhang, MD, PhD, of the Program in Cellular and Molecular Medicine at Children Hospital Boston and the IDI, reported their results online this week in the journal Cell.

While the immune system's T cells rapidly clear most EBV-infected B cells, about one in a million infected cells escapes destruction. Within these cells, the virus enters a latent phase, kept in check by the watchful eye of so-called memory T cells. This uneasy relationship usually holds steady the rest of a person's life, unless something such as infection with HIV or use of anti-rejection drugs following a transplant suppresses the immune system and breaks the surveillance. The virus can then reawaken and drive the development of B cell cancers like AIDS-associated B cell lymphoma and post-transplant lymphoproliferative disorder.

To better understand how the immune system maintains its watch and how the virus turns cells cancerous, Rajewsky and his team had generated a model mimicking latent EBV infection by engineering mice whose B cells contained an inducible version of viral LMP1. Researchers have long known that EBV needs LMP1 to turn B cells cancerous, but modeling this relationship in vivo had proven challenging.

"We had previously attempted to develop an animal model of LMP1 transformation of B cells," said Rajewsky, who recently moved to the Max D
'/>"/>

Contact: Erin Tornatore
erin.tornatore@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A single therapy slows multiple cancers
2. Widowers Who Stay Single Might Face More Mental Health Woes
3. Scientists capture single cancer molecules at work
4. Anti-estrogen combo better than single drug for hormone-sensitive breast cancer
5. Rice chemists cram 2 million nanorods into single cancer cell
6. New screening method can detect a range of clinical conditions from a single dried blood spot
7. Single dose of hallucinogen may create lasting personality change
8. Women have stronger immune systems than men and its all down to a single chromosome
9. Single parents and gay couples face rental housing discrimination: UBC study
10. Single vaccines to protect against both rabies and Ebola
11. Single flexible sigmoidoscopy screening associated with reduced colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 28, 2014 FAA-certified medical exams ... airplane, helicopter, gyroplan or airship, and should be completed ... balloons and gliders are exempt from the medical certificate ... is to alert potential pilots and contractors of any ... detecting these conditions early, the physicians at Healthpointe ...
(Date:7/28/2014)... 28, 2014 Ticket Down is ... Champions Cup Match between Manchester City and Liverpool FC ... Bronx has hosted countless big events since it opened several ... of the original Yankee Stadium, however, it has been a ... City metro area. , The Yankees Stadium is the ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 A lush green ... playtime during the summer. However, the summer heat, lack of ... to become brown, weak and unhealthy. The Grounds Guys recommends ... Grow, Mow a lawn once a week and set the ... normal. This protects the grass roots from heat and allows ...
(Date:7/28/2014)... Diego, CA (PRWEB) July 28, 2014 ... found that reduction of gluten intake in those who ... , Lisa Mittry, director of nutrition for San Diego ... information explaining various gluten considerations for those who are ... , Mittry explains that gluten is a protein, found ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Quincy Bioscience, ... , is pleased to announce the release of the ... company president and co-founder Mark Underwood. , The Brain ... information, offering useful techniques for readers to improve memory ... an unavoidable conclusion, The Brain Health Guide provides ways ...
Breaking Medicine News(10 mins):Health News:Healthpointe Invites All Aspiring Pilots to Complete an FAA Certified Exam 2Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 2Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 3Health News:Nurturing Lawns in the Summer Heat: The Grounds Guys® Offers Tips on Caring for Lawns This Summer 2Health News:VeraVia Explains the Basics of Gluten-Intolerance Following Industry Study 2Health News:VeraVia Explains the Basics of Gluten-Intolerance Following Industry Study 3Health News:Quincy Bioscience Launches the Fourth Edition of The Brain Health Guide 2
... hospital,s PackardVisionsystemPALO ALTO, Calif., March 3 Bedtime Bingo. ... few of the reasons Lucile Packard Children,s Hospital at ... environment. Now, with the launch of a "live" video ... hospital is offering kids and their families a Northern ...
... Tyco International Ltd. (NYSE: TYC ; BSX: ... Special General Meeting of shareholders on March 12, 2009 at ... The Annual General Meeting will begin at 9:00 a.m. Atlantic ... at 9:30 a.m. Atlantic Time. During the meetings, shareholders ...
... Calif., March 3 Onyx Pharmaceuticals, Inc. (Nasdaq: ... at the Barclays Capital Global Healthcare Conference on Tuesday, ... parties may access a live webcast of the presentation ... that listeners log on 15 minutes early in order ...
... Second Year with New Vendors for 2009COLUMBUS, Ohio, March ... an expansion of health information technology (HIT) use by ... budget has provisions for an increase in HIT funds ... $19 billion in Medicare and Medicaid HIT incentives including ...
... and 14th year of consecutive product revenue growth. ... support growing non-US business.Q4 2008 Highlights:- Product revenues ... 161% to $4.7 million - Over 31,700 Masimo ... were shipped in Q4 2008- International realignment results ...
... Informational Site -COMMACK, N.Y., March 3 ... an informational website devoted to their revolutionary ... GlycoCarn(R), "the ultimate nitric oxide and performance ... in the athletic, fitness and health world ...
Cached Medicine News:Health News:Monterey Bay Aquarium Channels Its Way to Kids at Packard Children's 2Health News:Monterey Bay Aquarium Channels Its Way to Kids at Packard Children's 3Health News:Tyco to Host 2009 Annual General Meeting and Special General Meeting of Shareholders 2Health News:OSMA's EMR Standards of Excellence Program Eases EMR Adoption Process 2Health News:OSMA's EMR Standards of Excellence Program Eases EMR Adoption Process 3Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 2Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 3Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 4Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 5Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 6Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 7Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 8Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 9Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 10Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 11Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 12Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 13Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 14Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 15Health News:Masimo Reports Fourth Quarter and Full Year 2008 Financial Results 16Health News:Sigma-tau HealthScience Launches www.GlycoCarn.com 2
(Date:7/28/2014)... Reportbuyer.com has added a new market research ... https://www.reportbuyer.com/product/2225723/Global-Bone-Densitometers-Market-2014-2018.html ... special type of X-ray test used to measure the ... to detect osteopenia or osteoporosis, diseases in which the ... is high. The purpose of bone densitometry is to ...
(Date:7/28/2014)... , July 28, 2014  Some 2,500 scientists ... month in Montreal for the ... -- a discipline that draws researchers from fields as ... problems as diverse as designing new manufacturing processes to ... a special time because the United Nations has declared ...
(Date:7/28/2014)... July 28, 2014  Air Products (NYSE: ... medical oxygen is vital to any healthcare facility. This ... not only improve the efficiency of its oxygen supply ... highlight these systems—including systems for emergency oxygen supply ... August 4-5 at the 51 st ASHE ...
Breaking Medicine Technology:Global Bone Densitometers Market 2014-2018 2Global Bone Densitometers Market 2014-2018 3Global Bone Densitometers Market 2014-2018 4Global Bone Densitometers Market 2014-2018 5All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 2All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 3All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 4All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 5All About Crystals: Tiny, Giant, from Mars, from Earth's Mantle, in Medicine and in Manufacturing 6Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3
... The Mini-Open Rotator Cuff Repair System ... procedure time, incision size and the ... other rotator cuff repair systems and ... sizes of matched cortical gauge punches, ...
Suture Cutters, Straight...
Suture scissor...
Threaded cannula for use with Suretac® II, sterile packs, box of 10....
Medicine Products: