Navigation Links
A single mild blast exposure can cause brain injuries with similarities to Alzheimer's disease
Date:9/24/2013

A new study published in the September issue of the Journal of Alzheimer's Disease reports that even a single mild explosion can cause changes in the brain that have similarities to those found in diseases like Alzheimer's disease and chronic traumatic encephalopathy.

Flying debris or getting thrown against other objects are not the only things that make explosions so dangerous. The primary shock waves that emanate from explosions also can kill a person if they are intense enough. However, most blast survivors experience less powerful shock waves that cause less severe immediate symptoms, such as temporary disorientation or headaches, but on the surface leave victims apparently unscathed. Scientists are especially concerned when these mild blast exposures happen repeatedly--likening them to the repetitive hits endured by boxers and other athletes.

"Some of the big questions in mild traumatic brain injury are about a molecule called tau" said Dr. David Cook of VA Puget Sound Health Care System and University of Washington. "In many brain diseases, tau gets chemically modified to create something called 'phospho-tau'. Phospho-tau is important because it is the starting building block of 'tau tangles', which can build up over time and damage brain cells."

The Seattle team used a rodent laboratory model to study brain changes caused by mild blast exposure. Dr. Cook noted, "We were a bit surprised to find that after only a single mild blast, phospho-tau remained elevated for at least a month."

"Tau pathology is part of end-stage TBI," said Dr. Iboja Cernak of the University of Alberta, Canada and a co-author on this report, "so, it is very interesting to discover that persistent phospho-tau increases also appear to be part of earlier phases of blast-induced neurotrauma".

These new findings raise the possibility that early-intervention with tau-based treatments may someday prove valuable in treating blast-induc
'/>"/>

Contact: VA Puget Sound Health Care System Office of Public Affairs
publicaffairspugetsound@va.gov
206-764-2317
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CNT Market - SWCNTs and MWCNTs Market (Single-Walled And Multi-Walled Carbon Nanotubes) worth US$3.3 Billion by 2016 - New Report by MarketsandMarkets
2. Imprivata is the Most Widely Selected Single Sign-On Solution by U.S. Hospitals Using McKesson Paragon or Horizon According to HIMSS Analytics
3. PlentyOfFish Acquires FastLife - the World’s Largest Speed Dating and Singles Event Company
4. Positive Singles Launched STD Support Features like STD Counselor and STD Treatment Stories
5. PositiveSingles.com Is Here To Stay
6. Bikerkiss.com Is a Biker Dating Site Which Is Now Helping Single Bikers to Find Love and Riding Partners
7. Nation’s First Robotic Single Incision (via Belly Button) Hernia Repair, Performed in an Outpatient Setting at K and B Surgical Center
8. More Than One Hundred Thousand American Single Moms Have Joined MillionaireMatch.com
9. PositiveSingles.com Launches A Unique New Feature That Will Notify Users When The Recipient Has Read Emails That They Send
10. Love is in the Air for HIV Positive Individuals at PositiveSingles.com
11. Darius Rucker to Perform Hit Single on MDA Show of Strength Telethon Labor Day Weekend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... issue of Experimental Biology and Medicine ... Gaskins and Paul Kenis in the Institute of ... University of Illinois Urbana-Champaign describe their recent work ... a variety of cell functions including energy metabolism, ... roles in regulating normal cellular behavior, redox status ...
(Date:4/17/2014)... AURORA, Colo. (April 17, 2014) Two recent ... Medicine researcher and colleagues may help scientists develop ... virus, Yellow fever, Japanese encephalitis and other disease-causing ... of biochemistry and molecular genetics at the School ... the Howard Hughes Medical Institute, and colleagues recently ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... personnel who served in Iraq and Afghanistan and ... (TBI) were compared to military personnel without TBI ... in measures of overall disability, cognitive function, post-traumatic ... reported in an article in Journal of ... Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... as 10 million older Americans suffer from depression, often ... However, new research a project that followed the ... years found that Internet use among the elderly ... 30 percent. , "That,s a very strong effect," said ... information studies and media who led the project. "And ...
Breaking Medicine News(10 mins):Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2
... researchers have discovered a new method to test for ... for chromosomal abnormalities are currently done through amniocentesis and ... scientists have been able to isolate single cells of ... woman with the help of a cervical swab. This ...
... delay your chances of getting treated// for cancer early. ... of Cancer, valuable time is lost when cancer patients goes ... suspected prostate cancer might be diagnosed three times later than ... gets treated for cancer. The average time for the diagnosis ...
... of inability to read in dyslexic children is// not ... thought in recent years. Instead, the dyslexic children may ... ,Dyslexia is one type of specific learning disability. ... verbal skills, abstract reasoning, hand-eye coordination, concentration, perception, memory ...
... School of Medicine have successfully discovered how the body’s ... like leprosy in some cases but not in others. ... system often fights with the infections in the initial ... they are unable to control the bug that it ...
... suffering from chronic lower back pain for more than a ... is done when no other treatment seems to bring them ... British Medical Journal reveled that in the long run this ... do not have enough finance to sustain a long-term medical ...
... sleep apnea syndrome affects a lot of people who ... top of having a difficult night, these people may ... ,Obstructive sleep apnea syndrome (OSAS), also known as ... heart problems, stroke, obesity, breathing problems, sexual dysfunction and ...
Cached Medicine News:
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) ... approval condition to the announced tender offer for all of the ... a result of the waiver, the transaction is no longer conditional ... on January 24, 2014 following the currently scheduled expiration time, subject ...
(Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
(Date:1/15/2014)... an unprecedented effort to curb the spread of "superbugs" such as ... an advanced and portable UV germicidal lamp manufactured by MRSA-UV is ... In order to prevent EMS paramedics and transport patients ... Palm Beach Fire Rescue is the first in the ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Superbugs No Longer Ride In Rescue Vehicles 2
... Combination Clinical Trials ... SOUTH SAN FRANCISCO, Calif., June 16 Sunesis,Pharmaceuticals, Inc. (Nasdaq: ... the company,s lead drug candidate, voreloxin (formerly,SNS-595), including updated results ... single agent in relapsed or refractory patients with acute,myeloid leukemia ...
... Requip XL Improved Symptoms in Patients Not Optimally ... "Off" Time by Nearly Two Hours Per Day, ... (NYSE: GSK ) today announced the approval ... for the treatment,of the signs and symptoms of ...
Cached Medicine Technology:Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association 2Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association 3Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association 4Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association 5Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association 6U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease 2U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease 3U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease 4U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: