Navigation Links
A single mild blast exposure can cause brain injuries with similarities to Alzheimer's disease
Date:9/24/2013

A new study published in the September issue of the Journal of Alzheimer's Disease reports that even a single mild explosion can cause changes in the brain that have similarities to those found in diseases like Alzheimer's disease and chronic traumatic encephalopathy.

Flying debris or getting thrown against other objects are not the only things that make explosions so dangerous. The primary shock waves that emanate from explosions also can kill a person if they are intense enough. However, most blast survivors experience less powerful shock waves that cause less severe immediate symptoms, such as temporary disorientation or headaches, but on the surface leave victims apparently unscathed. Scientists are especially concerned when these mild blast exposures happen repeatedly--likening them to the repetitive hits endured by boxers and other athletes.

"Some of the big questions in mild traumatic brain injury are about a molecule called tau" said Dr. David Cook of VA Puget Sound Health Care System and University of Washington. "In many brain diseases, tau gets chemically modified to create something called 'phospho-tau'. Phospho-tau is important because it is the starting building block of 'tau tangles', which can build up over time and damage brain cells."

The Seattle team used a rodent laboratory model to study brain changes caused by mild blast exposure. Dr. Cook noted, "We were a bit surprised to find that after only a single mild blast, phospho-tau remained elevated for at least a month."

"Tau pathology is part of end-stage TBI," said Dr. Iboja Cernak of the University of Alberta, Canada and a co-author on this report, "so, it is very interesting to discover that persistent phospho-tau increases also appear to be part of earlier phases of blast-induced neurotrauma".

These new findings raise the possibility that early-intervention with tau-based treatments may someday prove valuable in treating blast-induced neurotrauma.


'/>"/>

Contact: VA Puget Sound Health Care System Office of Public Affairs
publicaffairspugetsound@va.gov
206-764-2317
IOS Press
Source:Eurekalert

Related medicine news :

1. CNT Market - SWCNTs and MWCNTs Market (Single-Walled And Multi-Walled Carbon Nanotubes) worth US$3.3 Billion by 2016 - New Report by MarketsandMarkets
2. Imprivata is the Most Widely Selected Single Sign-On Solution by U.S. Hospitals Using McKesson Paragon or Horizon According to HIMSS Analytics
3. PlentyOfFish Acquires FastLife - the World’s Largest Speed Dating and Singles Event Company
4. Positive Singles Launched STD Support Features like STD Counselor and STD Treatment Stories
5. PositiveSingles.com Is Here To Stay
6. Bikerkiss.com Is a Biker Dating Site Which Is Now Helping Single Bikers to Find Love and Riding Partners
7. Nation’s First Robotic Single Incision (via Belly Button) Hernia Repair, Performed in an Outpatient Setting at K and B Surgical Center
8. More Than One Hundred Thousand American Single Moms Have Joined MillionaireMatch.com
9. PositiveSingles.com Launches A Unique New Feature That Will Notify Users When The Recipient Has Read Emails That They Send
10. Love is in the Air for HIV Positive Individuals at PositiveSingles.com
11. Darius Rucker to Perform Hit Single on MDA Show of Strength Telethon Labor Day Weekend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative ... National Family Partnership and the Drug Enforcement Administration as part of the National Red ... 10 winning schools who decorated their campuses with this year’s Red Ribbon Week theme: ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... Deloitte Wisconsin 75, an annual ranking and recognition of the largest closely held ... list, having ranked from 2008-2016. In addition, Standard Process was awarded the Talent ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For ... announced the opening of a new residential mental health treatment program in Chino ... issues such as severe anxiety, depression, bi-polar disorder, and other related issues. , ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... and stylish design wanted by today’s consumers at an affordable price, is now ... says the new watch is “a game changer” when it comes to the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 bioLytical Laboratories, un líder mundial en test rápidos ... HIV Self Test , a los miembros de la Kenya Pharmaceutical Association. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la ...
(Date:12/2/2016)... GARDENS, N.Y. , Dec. 2, 2016  LifeVac, ... will be included in the Emergency Response Training and ... are very excited to have LifeVac become part of ... Lih , Founder and CEO of LifeVac. "Having an ... LifeVac safely and effectively will help leverage our efforts ...
(Date:12/2/2016)... India , December 2, 2016 ... report "In Vitro Diagnostics/IVD Market by Product (Instruments, ... Hematology), Application (Diabetes, Oncology, Cardiology, Nephrology, Infectious Diseases) ... global market is valued at USD 60.22 Billion ... at a CAGR of 5.5% during the forecast ...
Breaking Medicine Technology: