Navigation Links
A silk coat for diamonds makes sleek new imaging and drug delivery tool
Date:1/27/2014

WASHINGTON, Jan. 27Silk and diamonds aren't just for ties and jewelry anymore. They're ingredients for a new kind of tiny glowing particle that could provide doctors and researchers with a novel technique for biological imaging and drug delivery.

The new particles, just tens of nanometers across, are made of diamond and covered in silk. They can be injected into living cells, and because they glow when illuminated with certain kinds of light, biologists can use them to peer inside cells and untangle the molecular circuitry that governs cellular behavior, or to study how cells react to a new drug. The silk-coated diamond particles could also potentially be used someday in the clinic, by allowing doctors to send infection-fighting antibiotics to a targeted area of the body.

A team of researchers from Australia and the United States describes this new hybrid diamond-silk material in a paper published today in The Optical Society's (OSA) journal Biomedical Optics Express.

Nanodiamonds similar to those in this study have been explored previously for their potential medical uses, but this is the first time silk has been incorporated with nanodiamonds, said Asma Khalid of the University of Melbourne, who is the first author of the Biomedical Optics Express paper. "This nanodiamond-silk hybrid material is important due to the potential it offers to the fields of bioimaging, biosensing and drug delivery," she explained.

Diamonds are crystals of carbon. But they can be made with defectsother atoms inserted in the crystal structureand these defects allow them to do tricks that flawless diamonds can't, such as absorbing and reemitting light of certain wavelengths, a process called fluorescence. Because these fluorescent nanodiamonds are bright, stable, and harmless to living tissue and can work at room temperature researchers have been exploring their use in biological imaging and sensing. But the edges around the particles tend to be rough and may cause the nanodiamonds to become trapped inside cell membranes.

Previously, other researchers have addressed this problem by coating the particles with lipids, a class of molecules found in fats and waxes. According to the new study, however, a better solution is to cover the nanodiamonds in silk, which is transparent, flexible, compatible with biological tissue, and biodegradable, so it won't leave any harmful byproducts inside the body.

When the researchers tested their new hybrid material, they found that the silk remains transparent, meaning that it does not block the glow of the nanodiamonds. They also discovered that the silk not only preserves the optical properties of the nanodiamonds, but it enhances their brightness by two to four times. Finally, the new material appears to be safe for use in the body: it left no damaging effects even after spending two weeks implanted inside living tissue, suggesting that it is nontoxic and non-inflammatory, the researchers say.

In the future, the team envisions a range of nanodiamond-silk structures that could help researchers improve techniques for fighting infections in targeted areas of the body. A thin film of the new substance, carrying drugs, could be implanted directly into an infected area, minimizing the patient's exposure to the drugs. Silk can also be designed to degrade at a certain rate, which would allow clinicians to control the release of medications.


'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
The Optical Society
Source:Eurekalert  

Related medicine news :

1. New system uses nanodiamonds to deliver chemotherapy drugs directly to brain tumors
2. Tolman and Wiker Insurance Services, LLC Sponsors ACT Today!’s 8th Annual Denim & Diamonds for Autism
3. Diamonds are a laser scientists new best friend
4. Puritas Organic Gold Presents ACT Today!’s 8th Denim & Diamonds for Autism, Star-studded Fundraiser to be held on October 6, 2013 in Westlake Village, CA
5. What makes cell division accurate?
6. Practice makes perfect if you have a partners touch, according to new study
7. InventHelp Client Introduces Kit - Invention Makes Nebulizer Masks More Child-Friendly (AUP-318)
8. Collection of Long Island Hearing Aid Reviews from East End Hearing Makes Selecting an Audiologist and a First Hearing Aid Easier
9. Green Park & Golf Ventures Makes a Major Investment in Socrates Health Solutions
10. PolyU Expert Makes First Space Tool for Lunar Exploration
11. Renegade Diabetes Company DollarDiabetesClub.com Breaks Barriers to Glucose Testing; New Online Club Makes Daily Glucose Testing Affordable for Everyone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A silk coat for diamonds makes sleek new imaging and drug delivery tool
(Date:7/20/2017)... ... July 20, 2017 , ... ... of non-invasive devices and systems for monitoring cardiopulmonary diseases, announced today that it ... used to complete regulatory submissions and fund final engineering and initial production of ...
(Date:7/20/2017)... ROUGE, La. (PRWEB) , ... July 20, 2017 , ... ... to the staff. Dr. Dunbar received his BS in Biology from LSU, graduating summa ... the Medical School Class President. After his residency in St. Louis, Dr. Dunbar moved ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... the Business Architecture Body of Knowledge (BIZBOK® Guide )v 6.0 is now available ... to this effort through Guild collaborative teams. , Non-members may download the ...
(Date:7/20/2017)... Charlotte, NC (PRWEB) , ... July 20, 2017 , ... ... announces the latest innovation to their product line: the AVE 2 birthing bed. , ... 2 helps bring a new level of comfort and efficiency to every phase of ...
(Date:7/20/2017)... ... ... At Creekwood Dental Arts, Drs. Donna G. Miller and Michelle Hinds are ... in Waco, TX, using the latest dental technology for digital imagery and bite ... details in the oral cavity for accurate diagnoses and customized care plans. These tools ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... 5, 2017 Wolfmet 3D  printed tungsten collimator manufactured by ... and manufacturing combine to progress molecular radiotherapy imaging. ... are unable to accurately quantify the radiation absorbed by those ... the success of this radiotherapy treatment has been available — ... ...
(Date:6/30/2017)... 30, 2017 In vitro diagnostics market firm ... May, at least ten diagnostic companies have successfully completed ... offerings and a loan facility.  The size of these ... million.  Kalorama Information provides a monthly IVD Market ... Knowledge Center. ...
(Date:6/20/2017)... LAGUNA HILLS, Calif. , June 20, ... data that validate the use of MMprofiler with SKY92, ... multiple myeloma (MM). In a poster presentation at the ... (EHA) in Madrid, Spain , SkylineDx ... identifying high-risk elderly patients. In a ...
Breaking Medicine Technology: