Navigation Links
A short and sweet diagnosis for cancer?
Date:7/9/2008

In order to provide the most effective treatments for cancer patients, it is essential to develop methods of sensitive and specific early detection of the disease. A team of scientists from the NIBRT Dublin-Oxford Glycobiology Laboratory at UCD has developed a system which aims to pinpoint potential "biomarkers" of early forms of the disease. They do this by looking at the structures of specific sugar molecules which are attached either to proteins made by cancerous cells or to proteins involved in the host response. It is hoped that the availability of such cancer biomarkers would also allow disease progression and response to therapy to be monitored more accurately than is currently possible. Professor Pauline Rudd, who is leading the team, will be presenting some of their results on Thursday 10th July at the Society for Experimental Biology's Annual Meeting in Marseille [Session C4].

It is known that cancer cells not only have different sets of proteins from normal human cells, but that their proteins have changes in the types and numbers of sugar molecules that are attached to them. Dr Rudd and her colleagues believe that being able to detect these changes holds the key to developing a new approach for diagnosing cancer. "We have found that there are alterations in sugars attached to proteins in blood serum from all cancers we have looked at, and some of these appear to be early markers of the disease processes. What is more, we have been able to isolate several sugar-linked variants of particular proteins which are associated with different types of cancer, including prostate, pancreatic and ovarian and breast cancers," she reveals. "In the long term, we envisage that by finding more specific sugar variants, we will be able to use combinations of these as biomarkers to allow very accurate early diagnosis of particular cancers". These techniques could act alongside or even replace physical methods, such as scanning, which are less dependable for early diagnosis.

In order to detect differences between cancerous and normal cells, the scientists are developing a robotic technique to analyse the sugars. "Sugars are removed from the proteins and then broken down into very small components using enzymes. These fragments can be individually characterised leading to the formation of a 'fingerprint' for each sugar we analyse," Professor Rudd explains. "By comparing the fingerprints of sugars from serum or individual proteins from cancer patients with those of disease-free people, we can find sugars which differ slightly between the two - these are the ones that are being tested as potential biomarkers. We are also refining a statistical analysis program which will enable more detailed examination of the data. As our method is high-throughput, we hope to be able to identify a large number of markers which can be taken forward for further testing and then clinical trials, leading to their potential use in both diagnosis and monitoring of cancer progression."


'/>"/>

Contact: Holly Astley
hma25@cam.ac.uk
44-779-285-5259
Society for Experimental Biology
Source:Eurekalert  

Related medicine news :

1. U.S. Teens Fall Short on Vaccine Coverage
2. Nicotine in Breast Milk Shortens Babys Naptime
3. Chicagoland Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
4. Psoriasis Cure Now Rolls Out First National Short Sleeve Day Saturday
5. DC Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
6. Salt Lake City Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
7. San Francisco Psoriasis Event Tonight Will Celebrate First National Short Sleeve Day
8. FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
9. Hospitals See Infection Rates More Than Halved, Patient Stays Shortened by 27 Percent in New Study Announced by I-Flow
10. Critical blood shortages eased by new technology
11. Physiotherapy has short-term benefits for patients after knee surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A short and sweet diagnosis for cancer?
(Date:6/27/2016)... ... June 27, 2016 , ... ePAY ... partnership with Connance, a healthcare industry leader providing predictive analytics to optimize ... combine to provide health systems, hospitals and ambulatory surgical centers with dramatic ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
Breaking Medicine Technology: