Navigation Links
A second ascent of chemistry's Mt. Everest
Date:12/12/2012

In science's equivalent of ascending Mt. Everest, researchers are reporting success in one of the most difficult challenges in synthetic chemistry a field in which scientists reproduce natural and other substances from jars of chemicals in a lab. The feat, reported in the Journal of the American Chemical Society, involved synthesis of a rare substance with promising in vitro anti-cancer effects found naturally in tiny amounts in a Chinese medicinal herb.

Samuel J. Danishefsky and Feng Peng explain that maoecrystal V occurs naturally in a plant growing in China's Yunnan province. Practitioners of Chinese traditional medicine have used the herb, called Isodon eriocalyx Hara, for hundreds of years. Scientists isolated maoecrystal V in 1994 and found that it has anti-cancer effects that warrant further examination. Large amounts would be needed to do so. However, the herb contains only small amounts of the material. In one experiment, it took more than 26 pounds of dried leaves to produce 0.00017637 oz. of maoecrystal V. In 2010, the first group of scientists succeeded in making maoecrystal V in a lab. Now, a second group has found a new route to the potential anti-cancer compound.

Danishefsky and Peng describe their approach as providing the basis for a synthesis that may help scientists develop a practical route to the substance for drug development and other research. It yielded a mixture of the two enantiomeric forms of maoecrystal V. They are pursuing several improvements, including a way to control the reactions to yield only a single enantiomer of the substance.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Secondhand Smoke Puts Children at Risk for Meningitis
2. Secondhand Smoke Very Unhealthy for Kids in Cars: Study
3. Smoking causes asthma in second generation offspring
4. Second Compounding Pharmacy Shut Down in Massachusetts
5. Secondhand Smoke: All It Takes Is 20 Minutes
6. Secondhand Smoke Takes Big Illness, Expense Toll
7. Secondhand Smoke in Pregnancy Seems to Harm Baby, Too
8. Secondhand Smoke Linked to Memory Problems
9. Adding bavituximab to second-line chemotherapy doubles response rate
10. Immunodeficient patients with secondary lung disease benefit from combined chemotherapy
11. Adding Plavix to Aspirin Doesnt Help Guard Against Second Stroke: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 26, 2017 , ... Miro is the ultimate smart media center that ... songs, movies, TV shows and much more apps for user exploration. Its innovative acoustic ... view of 1280 x 720 provides crisp images with remarkable clarity and color. The ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon ... is proud to announce an upgrade to the company's Yelp listing. Bay Area ... on topics as diverse as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques ...
(Date:2/26/2017)... ... 26, 2017 , ... NuevaCare, a leading home care agency based in San ... Alto, is proud to announce an important upgrade to its geographic information pages, starting ... close to home, and by having city-specific pages, NuevaCare is answering that information need. ...
(Date:2/26/2017)... ... 2017 , ... Functional imaging data supports improved cognition in ... today at the 1st Pan American Parkinson’s and Movement Disorders Congress. , It ... improving cognitive function in PD patients. This study, led by Ibarretxe-Bilbao et al., ...
(Date:2/24/2017)... ... February 24, 2017 , ... Only two months after the official ... (ILTM) show in Cannes (France), XO Private has initiated a second print-run of its ... measures almost a metre across when open, weighs in at more than six kilos, ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb 27, 2017 ... approved by NATO for use at the security level RESTRICTED. ... within the NATO organization for the communication of classified information. ... Sectra ... authorities with an eavesdrop-secure smartphone solution. Sectra Tiger/R is developed ...
(Date:2/24/2017)... Following receiving CE Marking in ... s AMAR is a major milestone for the country where the device ... care market in Israel   ... for inclusion in the National Health Basket , Israel ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment of ...
(Date:2/24/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... the Cowen and Company 37 th Annual Health ... Tuesday, March 7, 2017 at 11:20 a.m. Eastern Time. ... can be accessed at http://wsw.com/webcast/cowen38/zbh .  The webcast ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
Breaking Medicine Technology: