Navigation Links
A scientific breakthrough at the IRCM could help understand certain cancers
Date:6/13/2011

Montral, June 13, 2011 A scientific breakthrough by researchers at the Institut de recherches cliniques de Montral (IRCM) will be published tomorrow in Developmental Cell, a scientific journal of the Cell Press group. Led by Dr. Frdric Charron, the team of scientists discovered a new requirement for the proper functioning of the Sonic Hedgehog protein.

Sonic Hedgehog belongs to a family of proteins that gives cells the information needed for the embryo to develop properly. It plays a critical role in the development of many of the body's organs, such as the central nervous system. Malfunctions of these proteins are associated with many diseases including cancer, which is the leading cause of death in Canada.

"On one hand, certain molecules travel through our organs (in this case, Sonic Hedgehog) and transmit signals to cells with information on how they should function," explains Luisa Izzi, postdoctoral fellow in Dr. Charron's laboratory and co-first author of the article. "On the other hand, our cells have receptors to receive these signals. The receptors then instruct the cell's DNA as to which genes to turn on or off in order to perform its function."

The team studied the interactions between the Sonic Hedgehog molecule and the recently-identified receptors Boc, Cdon and Gas1, all found on the surface of cells. "Our research showed, unexpectedly, that these receptors are essential for the transmission of the hedgehog molecule's signal," adds Martin Lvesque, an alumnus from Dr. Charron's research unit and co-first author of the article.

"Disrupting the transmission of the Sonic Hedgehog signal can lead to diseases," says Dr. Charron, Director of the IRCM's Molecular Biology of Neural Development research unit. "A better knowledge of the receptors Boc, Cdon and Gas1 might in turn help our understanding of pathologies associated with defective Sonic Hedgehog signalling. Our results could also lead to new avenues for the treatment of certain diseases such as cancer."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related medicine news :

1. Neutrons poised to play big role in future scientific advances
2. FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee
3. Scientific community to set research agenda for infection prevention and control for next decade
4. 100 Day Countdown to the World Congress of Cardiology Scientific Sessions 2010
5. Fifty years of the light fantastic: Laser advances spark scientific progress
6. Star Scientific Files Annual Financial Report With SEC, Regains Compliance With NASDAQ Minimum Bid-Price Requirement
7. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
8. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
9. ACS Webinar focuses on immigration law for scientific professionals
10. Scientific meeting will host new research in childrens ear, nose and throat health
11. Endometriosis Foundation of America to Present Landmark Scientific Symposium in NYC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
Breaking Medicine Technology: