Navigation Links
A scanner for hereditary defects
Date:1/24/2013

Our DNA is constantly under attack from UV light, toxins and metabolic processes. Proteins and enzymes continually repair the damaged DNA. Unrecognized and therefore unrepaired damage to the genetic material, however, accelerates aging and causes cancer and genetic disorders. A team headed by veterinary pharmacologist and toxicologist Hanspeter Ngeli has now discovered that the protein XPD plays a key role in locating damaged DNA.

XPD protein as scanner

Genetic information is stored on approximately three billion base pairs of adenine/thymine or cytosine/guanine in the thread-like DNA double helix. The researchers reveal that the XPD protein works like a scanner that glides along the DNA double helix, scouring the bases for signs of damage. As soon as one of the protein's ferrous sensors encounters damage as it moves along, it is stopped, thereby marking damaged spots in need of repair. Besides patching up DNA, XPD is also involved in cell division and gene expression, thus making it one of the most versatile cell proteins.

Basis for possible courses of therapy

While repairing the DNA protects healthy body tissue from damage to the genetic material, however, it diminishes the impact of many chemotherapeutic substances against cancer. "Damage recognition using XPD opens up new possibilities to stimulate or suppress DNA repair according to the requirements and target tissue," explains Hanspeter Ngeli. The results could thus aid the development of new cancer treatments.


'/>"/>

Contact: Hanspeter Ngeli
naegelih@vetpharm.uzh.ch
41-446-358-763
University of Zurich
Source:Eurekalert  

Page: 1

Related medicine news :

1. Into the magnetic resonance scanner with a cuddly toy
2. Frequent MRI Scanner Exposure Might Affect Memory: Study
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. The prevention of hereditary breast and ovarian cancer by PGD is feasible
5. d'Oliveira & Associates Notes the Announcement of Zoloft Birth Defects Multidistrict Litigation (MDL) Set to Start in Mid-September 2014
6. Can a Parents Job Raise Odds for Birth Defects in Baby?
7. Hear to see: New method for the treatment of visual field defects
8. Erectile dysfunction drug may benefit cardiac function in young patients with heart defects
9. Facial defects shown to self-repair
10. Planning Pregnancy May Cut Birth Defects
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A scanner for hereditary defects
(Date:12/4/2016)... ... December 03, 2016 , ... ... "Best Surgical Body Shaping" at the 2016 Anti-Aging & Beauty Awards ... , The Aesthetic & Anti-Aging Medicine European Congress (AMEC) brings together ...
(Date:12/4/2016)... ... December 04, 2016 , ... Responsible dental care hinges on regular ... to achieve optimal results. This important necessity inspired an inventor from Las Vegas, Nev., ... to ensure that people break or avoid bad techniques of brushing the teeth in ...
(Date:12/2/2016)... ... ... twenty-four years, Doctors on Liens has published a directory of the top doctors ... When the company started in 1997, the directory was a single page focusing on ... ten-page directory features a vast array of medical specialists stretching from Sacramento to ...
(Date:12/2/2016)... ... 2016 , ... The annual time frame to change Medicare health and prescription ... December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan ... to make changes during this period order for their new policy to go into ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... Johnson & Weaver, LLP announces that a class action complaint ... Inc. (NYSE: ZBH )  securities during the period ... Period"). Zimmer Biomet provides musculoskeletal healthcare products and ... as knee and hip reconstructive products. ... , , ...
(Date:12/4/2016)... highly innovative, personalized cell-based treatment for a high-risk form of the most ... Children,s Hospital of Philadelphia today reported new results ... The physician-scientists presented findings at the annual meeting of the ... Continue Reading ... ...
(Date:12/2/2016)... 2016 bioLytical Laboratories, un líder mundial en test rápidos ... HIV Self Test , a los miembros de la Kenya Pharmaceutical Association. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la ...
Breaking Medicine Technology: