Navigation Links
A scanner for hereditary defects
Date:1/24/2013

Our DNA is constantly under attack from UV light, toxins and metabolic processes. Proteins and enzymes continually repair the damaged DNA. Unrecognized and therefore unrepaired damage to the genetic material, however, accelerates aging and causes cancer and genetic disorders. A team headed by veterinary pharmacologist and toxicologist Hanspeter Ngeli has now discovered that the protein XPD plays a key role in locating damaged DNA.

XPD protein as scanner

Genetic information is stored on approximately three billion base pairs of adenine/thymine or cytosine/guanine in the thread-like DNA double helix. The researchers reveal that the XPD protein works like a scanner that glides along the DNA double helix, scouring the bases for signs of damage. As soon as one of the protein's ferrous sensors encounters damage as it moves along, it is stopped, thereby marking damaged spots in need of repair. Besides patching up DNA, XPD is also involved in cell division and gene expression, thus making it one of the most versatile cell proteins.

Basis for possible courses of therapy

While repairing the DNA protects healthy body tissue from damage to the genetic material, however, it diminishes the impact of many chemotherapeutic substances against cancer. "Damage recognition using XPD opens up new possibilities to stimulate or suppress DNA repair according to the requirements and target tissue," explains Hanspeter Ngeli. The results could thus aid the development of new cancer treatments.


'/>"/>

Contact: Hanspeter Ngeli
naegelih@vetpharm.uzh.ch
41-446-358-763
University of Zurich
Source:Eurekalert  

Page: 1

Related medicine news :

1. Into the magnetic resonance scanner with a cuddly toy
2. Frequent MRI Scanner Exposure Might Affect Memory: Study
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. The prevention of hereditary breast and ovarian cancer by PGD is feasible
5. d'Oliveira & Associates Notes the Announcement of Zoloft Birth Defects Multidistrict Litigation (MDL) Set to Start in Mid-September 2014
6. Can a Parents Job Raise Odds for Birth Defects in Baby?
7. Hear to see: New method for the treatment of visual field defects
8. Erectile dysfunction drug may benefit cardiac function in young patients with heart defects
9. Facial defects shown to self-repair
10. Planning Pregnancy May Cut Birth Defects
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A scanner for hereditary defects
(Date:1/19/2017)... ... January 19, 2017 , ... Allegheny Health Network (AHN) officials today announced a ... the Network’s programs and services in the greater Pittsburgh region. Starting January 23, patients ... offered one for that same afternoon. , AHN is the first ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... asset protection and financial planning services to communities throughout eastern Georgia, is embarking ... against heart disease. , Heart disease kills more Americans every year than anything ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... owned insurance agency which serves Lawrenceville, New Jersey and the surrounding area, ... , Amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig's disease or ...
(Date:1/19/2017)... ... ... Attorney Robert “RC” Pate , founder of The Law Office of ... Kid Cancer foundation. Each year, 175,000 children are diagnosed with pediatric cancers. In 2006, ... of the critical funding gap for research into pediatric cancer research. From 2006 onwards, ...
(Date:1/19/2017)... ... January 19, 2017 , ... For the second ... Associates of Connecticut (RMACT) have earned “Top Doctor” awards. Dr. Mark Leondires, Dr. ... have each been chosen by their peers for the 2017 list based on ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... January 19, 2017 Incretin Mimetics/GLP-1 Agonists, SNDRIs, ... The global anti-obesity drugs market is expected ... of the forecast period and CAGR of 38.7% in the second ... at a CAGR of 32.8% from 2016 to 2027. The market ... and $24,063 million in 2027. ...
(Date:1/19/2017)... Calif. , Jan. 19, 2017 Accuray ... its CyberKnife® and TomoTherapy® Systems continue to set the ... received the highest composite overall user satisfaction rating among ... the Q4 2016 MD Buyline Market Intelligence Briefing™. The ... the highest composite ratings among industry peers for 11 ...
(Date:1/19/2017)... LONDON , January 19, 2017 ... Grothey ; European Oncology & Haematology, 2016;12(Suppl 2):3-8; ... ... http://photos.prnewswire.com/prnh/20151014/276718LOGO) Published recently in ... the peer-reviewed journal from touchONCOLOGY, an article by ...
Breaking Medicine Technology: