Navigation Links
A safer vaccination for Alzheimer's disease?
Date:10/11/2011

The research shows that in addition to the major histocompatibility complex (MHC) molecules, which present the antigen vaccine to the immune cells, genetic factors, that control some immune cells, influence the quality of response to vaccinations. The results could make it possible to prevent neuroinflammatory reactions, which are major obstacles preventing the use of the vaccination in humans. This study has just been published in the Journal of Immunology. Since the beginning of the 2000s, research into Alzheimer's disease has partly focussed on studying a vaccination composed of amyloid-β peptide (A), the accumulation of which in the brain is thought to trigger the disease. Vaccinations with this peptide caused serious neuroinflammatory reactions in 6% of patients. To develop a safer and more effective treatment, it is therefore essential to understand the factors that influence the body's responses to peptide A.

The joint Inserm/UPMC research team, led by Pierre Aucouturier, with Ccile Toly-Ndour and Guillaume Dorothe, conducted its research on mice with different forms of major histocompatibility complex (MHC). The role of these molecules is to present the antigens to the immune cells and they have a wide genetic diversity, which could explain the different responses. Indeed, after vaccination with the peptide A, mice with different MHC had different immune cell reactions. Researchers then pushed their studies further. By expressing the MHC from one line of mice to another, they demonstrated that factors in independent from MHC, but related to the genetic background, have a massive influence on the anti-A response. They then proved that these factors involve a sub-population of white blood cells (regulatory T cells).

These results provide a new direction to orientate immune cells advantageously, thus improving the immunotherapeutic approach, which remains one of the major hopes in the fight against Alzheimer's. However, these observations made on mice still require validation on human patients.


'/>"/>
Contact: Claire de Thoisy-Mchin
claire.de_thoisymechin@upmc.fr
33-014-427-2334
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related medicine news :

1. Nanotechnology holds promise for safer breast implants
2. CDC Moves to Make Organ Transplantation Safer
3. For safer food imports, Teach foreign lab workers US requirements
4. Mothers postpartum oxycodone use: No safer for breastfed infants than codeine
5. Newer techniques are making cardiac CT safer for children
6. Safer sex: Study examines sexual communication in transgender community
7. High-Risk Surgeries Getting Safer: Study
8. Fraunhofer MEVIS: New procedure to make brain surgery safer
9. Short antibiotic courses safer for breathing-tube infections in children
10. Unreliable outcomes measures hamper efforts to assure better, safer care
11. Safer CT scanning for children developed at the Queen Silvia Childrens Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... (PRWEB) , ... August 18, ... ... d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of ... entered into a definitive agreement to purchase Unitrans International Corporation, a division ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... McLean, VA (PRWEB) , ... August 18, 2017 ... ... offers asset protection services and financial consultations to communities throughout the greater DC ... Semper K9 with the goal of rescuing local animals and training them to ...
(Date:8/18/2017)... ... August 18, 2017 , ... MLM Insurance Group, a Miami ... southern Florida, is working to support the Take Stock In Children Foundation during ... families. , The Take Stock In Children Foundation (TSC) offers guidance and assistance ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance management ... spearheading a regional charity campaign organized to provide support to Christina Upchurch and her ... year, Christina and her children returned from out of town to find her husband ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) today ... effective Aug. 7, 2017. ... interests and will serve as president emeritus during a planned, ... in multiple leadership roles since he joined Diplomat with the ... provided decisive, strategic leadership which continues to benefit our patients ...
(Date:8/4/2017)... The search for test results that can ... has long been the goal of healthcare providers and ... the largest meeting of lab professionals and IVD firms ... firm Kalorama Information.  The firm said scores of companies ... supplies and software were at the American Association for ...
(Date:8/2/2017)... Fenita J. Caldwell is ... Lifetime Professional in the Field of Healthcare. Caldwell ... Pharmaceuticals, AG. Her skills and areas of expertise ... Fenita ... experience as a highly successful sales specialist in ...
Breaking Medicine Technology: