Navigation Links
A safer, more effective morphine may be possible with Indiana University discovery
Date:3/24/2011

INDIANAPOLIS An orphan drug originally used for HIV treatment has been found to short-circuit the process that results in additional sensitivity and pain from opioid use. The study by researchers at the Indiana University School of Medicine is reported in the March 25, 2011 issue of Brain, Behavior and Immunity.

The researchers say the finding in animal models may ultimately make morphine a safer and more effective drug.

Traditionally opioids were used to relieve pain following surgery, from cancer and at the end of life. Today opioids are used widely for chronically painful conditions like osteoarthritis and back pain and may need to be prescribed for decades.

Morphine, the gold standard for controlling moderate to severe pain, has debilitating side effects including reduced respiration, constipation, itching and addiction. Patients also develop a tolerance to morphine which can lead to a complicated spiral.

"In addition to the recognized side effects, morphine actually creates sensitivity and causes more pain through inducing an inflammatory response in the body," said first author Natalie Wilson, a National Science Foundation Fellow at the IU School of Medicine.

This increased sensitivity is clinically known as opioid-induced hyperalgesia (OIH). Frequently, patients receiving opioids for pain control may actually become more sensitive to certain painful stimuli necessitating an increased opioid dosage. OIH may also represent one of many reasons for declining levels of analgesia while receiving opioids or a worsening pain syndrome.

"The drug itself is producing its own new pain," said Fletcher A. White, Ph.D., Vergil K. Stoelting Professor of Anesthesia and director of Anesthesia Research at the IU School of Medicine. "I tend to view it as an injury as it appears to be creating another pain."

Dr. White explained that morphine sets into motion a cascade of events, one of which is to
'/>"/>

Contact: Mary L. Hardin
mhardin@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
2. Why do physicians order costly CTs? Ultrasound yields better diagnosis, safer, less costly
3. Study finds everolimus-eluting stent safer, more effective than paclitaxel-eluting stent
4. Toys Getting Safer, But Dangers Still Lurk: Report
5. Secrets of plant warfare underpin quest for safer, more secure global food supply
6. Low forms of cyclin E reduce breast cancer drugs effectiveness
7. Gastric Banding Most Effective for Obese Teens
8. Neuroimaging study may pave way for effective Alzheimers treatments
9. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
10. Charging less for more effective treatments could reduce health care costs while improving health
11. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A safer, more effective morphine may be possible with Indiana University discovery
(Date:7/30/2015)... ... July 30, 2015 , ... The Beryl Institute ... Program. In partnership with Patient Experience Institute, these offerings reinforce the commitment to ... front lines and throughout the experience movement, and provide information and research to ...
(Date:7/30/2015)... ... 30, 2015 , ... Ross A. Clevens, MD, FACS has been ... of Plastic Surgery. This is Dr. Clevens’ second appointment by the prestigious school. ... developing a strong presence and a valuable mentoring program for medical students. ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... the ‘Mary Jo Lawyer-Spano Mesothelioma Patient Registry Act of 2015’. The bill ... Chris Collins (R-NY), Peter King (R-NY), Betty McCollum (D-MN), Joe Kennedy (D-MA), and ...
(Date:7/30/2015)... ... July 30, 2015 , ... Using the latest online ... teach people more effective ways to prevent and manage major depression. , “Suicide is ... enough, so people fall through the cracks and die needlessly everyday,” says Walker. “I’m ...
(Date:7/30/2015)... ... July 30, 2015 , ... Boston ... the annual All-Stars Summit. Google Partners is the platform for search marketing agencies ... full support and tools necessary to run successful search marketing campaigns. Google Partners ...
Breaking Medicine News(10 mins):Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 3Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 3Health News:Bill to Create Patient Registry for Deadly Cancer Introduced in Congress 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3Health News:Boston Web Marketing Attends Google Partners All-Stars Summit 2
... , Thursday, Sept. 15, 2011, Cleveland: Researchers at Cleveland Clinic ... (NIH) to continue studying the effectiveness of a blood test ... The test using blood samples taken before and after ... which signifies brain damage if found in elevated levels in ...
... HealthDay Reporter , THURSDAY, Sept. 15 (HealthDay News) -- Those "senior ... not be a sign of more serious problems down the ... or forgetting where you placed your keys may be a fairly ... remembering what happened a few minutes ago, or getting lost in ...
... Drinking heavily may increase a person,s risk of dying in ... involved the risk of death is even higher, the Australian ... could have survived had they reacted in time. ... 95 fire victims in Australia. The researchers found that 58 ...
... Orleans, LA Research led by Dr. Suresh Alahari, the ... Health Sciences Center New Orleans and its Stanley S. Scott ... laboratory can inhibit the growth of breast cancer cells. The ... Journal of the National Cancer Institute . Building ...
... Reporter , WEDNESDAY, Sept. 14 (HealthDay News) -- Normal-weight ... the "metabolic syndrome" could face a higher risk for ... new research suggests. Metabolic syndrome is characterized by ... insulin levels, excess body fat around the waist, high ...
... Hospitals (UH) Case Medical Center,s Division of Pain ... Epilepsy Center in the UH Neurological Institute have ... Awards from Pfizer Inc. Institutions for these ... an independent academic selection committee comprised of leaders ...
Cached Medicine News:Health News:Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test 2Health News:Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test 3Health News:Certain 'Senior Moments' May Signal Mental Decline 2Health News:Certain 'Senior Moments' May Signal Mental Decline 3Health News:Heavy Drinking Ups Odds of Death in House Fire 2Health News:Protein discovered at LSUHSC may suppress breast cancer growth 2Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 2Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 3Health News:Certain Risk Factors Could Spur Heart Failure in Normal-Weight People 4
(Date:7/30/2015)... Company, Inc. (NYSE: LCI ) today announced that ... Annual Growth Conference on Wednesday, August 12, 2015, at ... A webcast of the presentation will be ... visit the web site at least 10 minutes prior ... and install any necessary software.  The presentation will be ...
(Date:7/30/2015)... -- Flexpoint Ford, a private equity firm focused on ... it has entered into a partnership with Alan ... Kastle Therapeutics, LLC (Kastle).  The new company, headquartered in ... developing and commercializing pharmaceuticals targeted toward diseases with high ... already approved for marketing, as well as clinical assets ...
(Date:7/30/2015)... 30, 2015   HeartWare International, Inc . ... less invasive, miniaturized circulatory support technologies that are ... announced total revenue of $73.6 million for the ... million for the quarter ended June 30, 2014. ... million, or nine percentage points, during the three ...
Breaking Medicine Technology:Flexpoint Ford Announces Partnership with Alan MacKenzie and Bryan Stuart to Form Kastle Therapeutics 2Flexpoint Ford Announces Partnership with Alan MacKenzie and Bryan Stuart to Form Kastle Therapeutics 3HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 2HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 3HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 4HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 5HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 6HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 7HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 8HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 9HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 10HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 11HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 12HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 13HeartWare International Reports $73.6 Million In Second Quarter 2015 Revenue, Driven By Strong Global Unit Growth 14
... and best value in high performance electronic ... ultra lightweight design reduce hand fatigue and ... lever tip ejector , Color coding for ... or for greater performance use Hamilton AdvanTip ...
... The Finnpipette BioControl multichannel ... features as the single ... handle fits allseven multichannel ... tip cone modules. Both ...
... Pipette is ideal for all liquid handling ... ergonomically-placed operating buttons, and various dispensing techniques ... diluting make this a lab favorite. It ... manual pipette without any adverse effects on ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
Medicine Products: