Navigation Links
A safer, more effective morphine may be possible with Indiana University discovery
Date:3/24/2011

INDIANAPOLIS An orphan drug originally used for HIV treatment has been found to short-circuit the process that results in additional sensitivity and pain from opioid use. The study by researchers at the Indiana University School of Medicine is reported in the March 25, 2011 issue of Brain, Behavior and Immunity.

The researchers say the finding in animal models may ultimately make morphine a safer and more effective drug.

Traditionally opioids were used to relieve pain following surgery, from cancer and at the end of life. Today opioids are used widely for chronically painful conditions like osteoarthritis and back pain and may need to be prescribed for decades.

Morphine, the gold standard for controlling moderate to severe pain, has debilitating side effects including reduced respiration, constipation, itching and addiction. Patients also develop a tolerance to morphine which can lead to a complicated spiral.

"In addition to the recognized side effects, morphine actually creates sensitivity and causes more pain through inducing an inflammatory response in the body," said first author Natalie Wilson, a National Science Foundation Fellow at the IU School of Medicine.

This increased sensitivity is clinically known as opioid-induced hyperalgesia (OIH). Frequently, patients receiving opioids for pain control may actually become more sensitive to certain painful stimuli necessitating an increased opioid dosage. OIH may also represent one of many reasons for declining levels of analgesia while receiving opioids or a worsening pain syndrome.

"The drug itself is producing its own new pain," said Fletcher A. White, Ph.D., Vergil K. Stoelting Professor of Anesthesia and director of Anesthesia Research at the IU School of Medicine. "I tend to view it as an injury as it appears to be creating another pain."

Dr. White explained that morphine sets into motion a cascade of events, one of which is to
'/>"/>

Contact: Mary L. Hardin
mhardin@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
2. Why do physicians order costly CTs? Ultrasound yields better diagnosis, safer, less costly
3. Study finds everolimus-eluting stent safer, more effective than paclitaxel-eluting stent
4. Toys Getting Safer, But Dangers Still Lurk: Report
5. Secrets of plant warfare underpin quest for safer, more secure global food supply
6. Low forms of cyclin E reduce breast cancer drugs effectiveness
7. Gastric Banding Most Effective for Obese Teens
8. Neuroimaging study may pave way for effective Alzheimers treatments
9. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
10. Charging less for more effective treatments could reduce health care costs while improving health
11. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A safer, more effective morphine may be possible with Indiana University discovery
(Date:4/21/2015)... 21, 2015 Now, busy Diet Doc clients ... company’s new diet breakfast omelets. Like Diet Doc’s ... in dry ice and are delivered directly to their door. ... southwestern omelets that not only appeal to the taste buds, ... ideal weight with healthy, low carbohydrate meals. , One ...
(Date:4/21/2015)... 2015 Pharmacy point of sale ... year's Independent Pharmacy Cooperative trade show, to be held ... Beach. , Retail Management Solutions recently became an approved ... Mike Gross, VP of Sales and Marketing. Gross says ... pharmacy trade shows in the country -- and this ...
(Date:4/21/2015)... Lifeguard Master is out with their new ... listed on the Lifeguard Master website and are in stock. ... want a quality and flexible product during their rescue efforts. ... color Spider Straps are some of the most popular items ... sturdy, heavy nylon” , The Spider Straps are rated superior ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 The ... at the beautiful Governor’s Academy prep school in Byfield, ... July 10-12, 2015, for boys entering grades 6-12. , ... and supplement the players’ fall coaching. , ... athletes. Not only are these the most unsung positions ...
(Date:4/21/2015)... 2015 Renewable energy, sustainable living, the ... the Earth Day topics USM Studios ’ programming ... debate the affect of climate change on the planet, ... matter touching on the environmental concerns affecting the nation ... into sustainable lifestyles, clean air options, and much more ...
Breaking Medicine News(10 mins):Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 2Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 3Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 4Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 2Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 2Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 4Health News:US Sports Camps and The Northeast Football Clinic Announce 2015 Lineman/Linebacker Clinic Schedule 2Health News:USM Studios’ Programming Focuses on the Environment 2
... Md., May 7 Vaccinogen Inc. said Dutch health,authorities ... immediately clearing the path to more than $100 million ... company,s facility based in Emmen, The,Netherlands also paves the ... -- the final step before the vaccine can be ...
... Holdings Corp. (Nasdaq:,HMSY) today announced that it will present ... be held May 13-15, 2008 at the Four,Seasons in ... Walter Hosp, Chief Financial,Officer of HMS Holdings Corp., will ... HMS Holdings Corp. (Nasdaq: HMSY ) is the ...
... technology will enable physicians to have secure access to, online patient ... ... telephones, MANCHESTER, N.H., May 7 New Hampshire physicians ... Anthem patients, virtually anywhere they can receive an internet,signal, thanks to an ...
... U.S. Department,of Health and Human Services published an update ... Tobacco Use and Dependence,which contains revised and improved recommendations ... smokers in quitting. The,guideline also confirms that there has ... right now., With the release of these new ...
... May 7 /PRNewswire-USNewswire/ - The International,Academy of Compounding ... doctors in applauding the introduction of H. Con. ... and Drug Administration,s,(FDA) new policy restricting women,s access ... interest" and calling on the FDA to,"reverse its ...
... Pa., May 7 Select Medical Corporation,will release the ... on Thursday, May 15, 2008., The Company will ... Wednesday, May 21, 2008, at 11:00am EDT. The domestic ... dial in number is,1-210-839-8503. The passcode for the call ...
Cached Medicine News:Health News:Dutch Authorize Manufacture of Vaccinogen's New Cancer Vaccine; License Clears Path to European Production, Final FDA Trial 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Announces Unique Enhancement to its ePrescribing Program 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Announces Unique Enhancement to its ePrescribing Program 3Health News:New Smoking Cessation Guideline Confirms That Now is the Time to Quit Smoking 2Health News:Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol 2Health News:Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol 3
(Date:4/20/2015)... KUALA LUMPUR, Malaysia , April 20, 2015 /PRNewswire/ ... 2015, resulting in a scarcity of opportunities for generic ... drug manufacturers in the region are looking beyond the ... the quality of existing drugs. Certain established generic manufacturers ... research and development of new molecules, although the impact ...
(Date:4/20/2015)... Dr. Gregory Taylor , Canada,s Chief ... after spending a week in West Africa . ... needs on the ground as global efforts continue to reach zero ... prevention efforts in Sierra Leone and ... first-hand the work being done and hear from those on the ...
(Date:4/20/2015)... 20, 2015 Actavis plc (NYSE: ... Mayr , Chief Communications Officer, will retire from ...  In conjunction with Mayr,s retirement, Alex Kelly ... of Chief Communications Officer, effective immediately. Prior to ... Vice President, Chief Communications Officer, Public Affairs and ...
Breaking Medicine Technology:Generic Drug Companies in Asia Focus More on Market Expansion and Quality, Less on Patent Cliff, Finds Frost & Sullivan 2Generic Drug Companies in Asia Focus More on Market Expansion and Quality, Less on Patent Cliff, Finds Frost & Sullivan 3Generic Drug Companies in Asia Focus More on Market Expansion and Quality, Less on Patent Cliff, Finds Frost & Sullivan 4Generic Drug Companies in Asia Focus More on Market Expansion and Quality, Less on Patent Cliff, Finds Frost & Sullivan 5Canada's Efforts Making a Difference in the Fight Against Ebola 2Canada's Efforts Making a Difference in the Fight Against Ebola 3Canada's Efforts Making a Difference in the Fight Against Ebola 4Canada's Efforts Making a Difference in the Fight Against Ebola 5Actavis Announces Retirement of Charles M. Mayr 2Actavis Announces Retirement of Charles M. Mayr 3
... and urethral pressure profilometry. Dual ... to be filled while cystometry ... catheter design enhances visualization during ... in peel-open packages. Intended for ...
... Scientifics SAFE-T-FILL Capillary Blood Collection Tubes are ... for a wide range of applications, the ... capillary tube, attached cap and a micro ... draw the blood into the micro tube ...
... RAM Scientifics SAFE-T-FILL Capillary Blood Collection ... systems. Available for a wide range of ... with a capillary tube, attached cap and ... action to draw the blood into the ...
... RAM Scientifics SAFE-T-FILL Capillary Blood Collection Tubes ... Available for a wide range of applications, ... a capillary tube, attached cap and a ... to draw the blood into the micro ...
Medicine Products: