Navigation Links
A revolutionary new way of reversing certain cancers
Date:9/28/2010

Australian and American scientists have found a way of shrinking tumours in certain cancers a finding that provides hope for new treatments.

The cancers in question are those caused by a new class of genes known as 'microRNAs', produced by parts of the genome that, until recently, were dismissed as 'junk DNA'. While much is still unknown about microRNAs, it is clear that they can interfere with how our genes are 'read'.

The current finding identifies one particular microRNA (microRNA 380) that appears to disable the king of tumour suppressors, the P53 gene. So important is P53, that it is known as the 'guardian of the genome'. In order for a cell to become cancerous, P53 must either be mutated or otherwise disabled.

Dr Alex Swarbrick, from Sydney's Garvan Institute of Medical Research, Dr Susan Woods from Brisbane's Queensland Institute of Medical Research and Dr Andrei Goga from The University of California San Francisco chose to study neuroblastoma, a childhood cancer of the nervous system in which 99% of patients do not have mutations of the P53 gene.

The researchers found instead that neuroblastomas disable p53 by over-producing microRNA 380. When they blocked the microRNA, P53 production resumed, cancer cells died and tumours became much smaller. Their results are reported in the prestigious international journal Nature Medicine, online today.

"The revolutionary thing about this finding is that it's the first time anyone has blocked the growth of a primary tumour by the simple delivery of a microRNA inhibitor," said Swarbrick.

"By that, I mean we delivered the microRNA inhibitor in a way we might give it to a person as a twice-weekly injection not using some genetic trick. It's the closest thing to a clinical result that's yet been published."

"That, of course, makes this microRNA a potential therapeutic target for all cancers that depend on it."

"The other good news is that you don't find this microRNA in normal adult cells. It's very active while we are developing embryos, when cells need to divide very quickly, but after that it appears to get switched off. So by blocking it, you're effectively returning cells to normal."

"We still don't know why it gets switched on again in certain cancers. Apart from neuroblastomas, we often see it in brain tumours and in melanomas that don't have mutations in P53."

So how exactly does it work?

When a gene is transcribed or "read", in this case P53, a copy of the gene is made in RNA. In a normal cell, that P53 RNA carries the instructions to make P53 proteins, which in turn carry out the tumour suppressor function in cells.

"MicroRNAs act to control the production of proteins the molecules that do the work in cells," explained Swarbrick.

"In the cancers we are discussing, our microRNA binds with P53 RNA, preventing it from making proteins. That effectively reduces the number of P53 proteins in a cell and allows the tumour to grow."

"Understanding that certain cancers appear to be regulated like this gives us a new avenue to explore in their treatment."

While this finding is at an early research stage, it holds much promise for the future treatment of early childhood neuroblastomas and other microRNA- induced cancers.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Research Australia
Source:Eurekalert

Related medicine news :

1. Revolutionary therapy slows tumor growth in advanced breast cancer, Penn research reports
2. Beverly Hills Aesthetics Offers Revolutionary New Celluraze Procedure
3. ELLKAY Introduces Revolutionary Live Insurance Mapping Solution for Diagnostic Laboratories
4. Revolutionary Sports Bottle Unscrews at Both Ends for Easy Cleaning -- Never Deal With Stinky, Moldy Bottles Again
5. Comparing Tuition and Fees Just Got Easier With College Equalizer, the New Revolutionary College Search System Set to Launch Soon
6. Revolutionary scale makes losing weight easier than ever
7. Brain Academy's Revolutionary New Approach to Tutoring and Test Prep Helps Students Find Academic Success
8. Shakti, Inc. Brings Knee, Back and Foot Comfort with Revolutionary Medical-Based Technology
9. New Laser Treatment Offers Revolutionary Response to Aesthetic Procedure Candidates' Number One Concern: Recovery Time
10. Good Look Ink Announces Revolutionary Hair Replication Solution
11. Mammoth Selection Announces Revolutionary New Elite Air Purifier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... Birmingham, Clarkston, Lake Orion, Michigan (PRWEB) , ... ... ... Endometriosis is a disease affecting the female reproductive tract in which ... itself on the pelvic structures causing inflammation and pain. Patients experiencing painful ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... practice is offering holistic pediatric dentistry options for its patients on Long Island, ... the patient’s entire physical well being, and is one of the biggest trends ...
(Date:5/24/2017)... West Orange, NJ (PRWEB) , ... May 24, 2017 , ... ... ingredients for avoiding back injury when either lifting weights for strength training and exercise ... Atlantic Spine Center . , “Body position is everything,” Dr. Chang says. “Improper ...
(Date:5/23/2017)... ... 23, 2017 , ... Allegheny Health Network and the Alexis ... for Women’s Behavioral Health at West Penn Hospital , a unique facility that ... from pregnancy-related depression. Construction of the Center is underway with a scheduled opening ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... (PHM) technology and a 2017 Best in KLAS category winner, has named Daniel ... position to extend and enhance its technology platform and product offerings,” says Justin ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... 2017  A recent study published in the ... light as a means of disinfection anesthesia workstations ... bioburden on anesthesia workstations. In the study, UVC ... medical equipment surfaces contaminated with three (3) organisms ... study further validates the body of literature supporting ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017  The ... Clinical and Scientific Meeting— OBP Medical , a leading ... announced the launch of a new extra-small size and ... ER-SPEC vaginal specula. Already available in small, ... sizes makes OBP Medical,s line of single-use lighted specula ...
(Date:5/4/2017)...  A new tight-tolerance microextrusion medical tubing product ... is being launched by Natvar, a Tekni-Plex company. ... recent years to service a wide variety of ... expensive materials such as glass and fluoropolymers have ... their ability to consistently hold tolerances. This is ...
Breaking Medicine Technology: