Navigation Links
A relationship between cancer genes and the reprogramming gene SOX2 discovered
Date:12/6/2012

A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that the cellular reprogramming gene SOX2, which is involved in several types of cancers, such as lung cancer and pituitary cancer, is directly regulated by the tumor suppressor CDKN1B(p27) gene, which is also associated with these types of cancer.

The same edition of the online version of the journal also includes a study led by Massimo Squatrito, who recently joined the CNIO to direct the Seve Ballesteros Foundation Brain Tumour Group. This study, carried out in Eric C. Holland's laboratory, at the Memorial Sloan Kettering Cancer Center (MSKCC), in Nueva York, shows the relationship between MEF, a gene regulator involved glioblastomas - the most aggressive and common brain tumours -, and SOX2.

YAMANAKA'S CELLULAR REPROGRAMMING CONTINUES TO SURPRISE

The cell reprogramming process, discovered by this year's Nobel Prize winner, Shinya Yamanaka, has become a powerful tool for researchers. Via the introduction of a cocktail of four genes into cells, among them SOX2, scientists can reprogram cells and transform them into stem cells which can be used to study a variety of processes, including cancer.

The research team led by Manuel Serrano and Manuel Collado was interested in the possible role of the tumour suppressor gene CDKN1B(p27) in reprogramming. During the course of these studies, Han Li, first author of the study, unexpectedly discovered that cells deficient in the CDKN1B(p27) gene could be reprogrammed without the need to introduce SOX2. This observation was the starting point to unravel the functional relationship between both genes.

The work led by Squatrito, in which the researcher Elena Bazzoli figures as first author, was based on earlier works that linked SOX2 with tumorigenesis. The article describes how SOX2 is regulated by MEF in cells of the nervous system. "Brain tumour cells acquire stem cell traits thanks to the participation of SOX2, and this produces an increase in tumorigenic potential" states Squatrito.

These new insights help to understand the origin of cancers linked to CDKN1B(p27) and MEF, and highlight the potential role of adult stem cells in cancer.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Expert Marriage & Relationship Therapist Is Offering Free Professional Assistance To Porn Addicts
2. Marriage & Relationship Therapist Launches A Website To Help Porn Addicts
3. Porn Addicts Can Now Find Free Professional Assistance from a Relationship & Marriage Therapist’s New Website
4. Breakthrough Brings Transparency to Male/Female Relationships
5. A stronger doctor-patient relationship for the costliest patients
6. Studying couples to improve health, better relationships
7. Lets talk: The nature of the health care surrogate-clinician relationship
8. Internists recommend principles on role of governments in regulating patient-physician relationship
9. Study examines the relationship between marriage and alcohol
10. Divorced parents in hostile relationships use technology to sabotage communication, MU study finds
11. During IVF sexual relationships, satisfaction, can suffer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... It's ... there are a number of illnesses that are unclear as to whether or not ... their heads. Bronchitis is one of these illnesses. So, FindaTopDoc took a look into ...
(Date:4/28/2017)... ... ... affects much more than energy – it also has mental and physical benefits. According to ... time, which can increase the risk of having a car accident. , This week ... to help you sleep better and feel better:, , Turn off ...
(Date:4/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... election process has been in place since the RBMA was founded in 1968 with ... succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... America (UCAOA) and College of Urgent Care Medicine will host industry leaders for ... and speakers will help those in the industry adapt to the issues currently ...
(Date:4/28/2017)... ... April 28, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... Creator responds to and which He does not. Yisrayl says with so many titles ... the true name, but he says with a little Scripture, backed with a lot of ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... EAST HANOVER, N.J. , April 19, 2017 ... study conducted by the National Heart, Lung, and ... Health (NIH) demonstrating that 58% of patients with ... at six months when treated with eltrombopag at ... treatment 1 . The study evaluated three sequential ...
(Date:4/18/2017)... April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and providing ... is in conjunction with this morning,s announcement of the ... and Nutritional Insufficiency businesses. Cardinal Health now ... will be at the bottom of its previous guidance ...
(Date:4/18/2017)... Viverae ® , a leader in workplace ... IBM ® Watson Campaign Automation, implementing behavioral messaging ... a personalized experience. Through digital engagement, the platform prompts ... real time. The enhanced experience drives engagement by focusing ... they are in their journey to health. ...
Breaking Medicine Technology: