Navigation Links
A relationship between cancer genes and the reprogramming gene SOX2 discovered
Date:12/6/2012

A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that the cellular reprogramming gene SOX2, which is involved in several types of cancers, such as lung cancer and pituitary cancer, is directly regulated by the tumor suppressor CDKN1B(p27) gene, which is also associated with these types of cancer.

The same edition of the online version of the journal also includes a study led by Massimo Squatrito, who recently joined the CNIO to direct the Seve Ballesteros Foundation Brain Tumour Group. This study, carried out in Eric C. Holland's laboratory, at the Memorial Sloan Kettering Cancer Center (MSKCC), in Nueva York, shows the relationship between MEF, a gene regulator involved glioblastomas - the most aggressive and common brain tumours -, and SOX2.

YAMANAKA'S CELLULAR REPROGRAMMING CONTINUES TO SURPRISE

The cell reprogramming process, discovered by this year's Nobel Prize winner, Shinya Yamanaka, has become a powerful tool for researchers. Via the introduction of a cocktail of four genes into cells, among them SOX2, scientists can reprogram cells and transform them into stem cells which can be used to study a variety of processes, including cancer.

The research team led by Manuel Serrano and Manuel Collado was interested in the possible role of the tumour suppressor gene CDKN1B(p27) in reprogramming. During the course of these studies, Han Li, first author of the study, unexpectedly discovered that cells deficient in the CDKN1B(p27) gene could be reprogrammed without the need to introduce SOX2. This observation was the starting point to unravel the functional relationship between both genes.

The work led by Squatrito, in which the researcher Elena Bazzoli figures as first author, was based on earlier works that linked SOX2 with tumorigenesis. The article describes how SOX2 is regulated by MEF in cells of the nervous system. "Brain tumour cells acquire stem cell traits thanks to the participation of SOX2, and this produces an increase in tumorigenic potential" states Squatrito.

These new insights help to understand the origin of cancers linked to CDKN1B(p27) and MEF, and highlight the potential role of adult stem cells in cancer.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Expert Marriage & Relationship Therapist Is Offering Free Professional Assistance To Porn Addicts
2. Marriage & Relationship Therapist Launches A Website To Help Porn Addicts
3. Porn Addicts Can Now Find Free Professional Assistance from a Relationship & Marriage Therapist’s New Website
4. Breakthrough Brings Transparency to Male/Female Relationships
5. A stronger doctor-patient relationship for the costliest patients
6. Studying couples to improve health, better relationships
7. Lets talk: The nature of the health care surrogate-clinician relationship
8. Internists recommend principles on role of governments in regulating patient-physician relationship
9. Study examines the relationship between marriage and alcohol
10. Divorced parents in hostile relationships use technology to sabotage communication, MU study finds
11. During IVF sexual relationships, satisfaction, can suffer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Norwalk, CT (PRWEB) , ... December 07, 2016 ... ... the Integrated Infertility and Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut ... which now has a team of three acupuncturists to help patients realize their ...
(Date:12/7/2016)... ... ... With God: Inspirational Lessons from My Life's Journey”: a sometimes serious, sometimes humorous ... in their lives. “Walking With God: Inspirational Lessons from My Life's Journey” is the ... , Sanford says, “I enjoy sharing the true stories in my book as examples ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... annual Business Architecture Innovation Summit in Reston, VA on March 21-22, 2017. This ... share a range of experiences from a cross-section of industries such as financial ...
(Date:12/7/2016)... ... December 07, 2016 , ... "Hacking into my medical ... described him as 'a genius.'" Thus begins "Margaret in Berlin," Book Twelve in the ... by Wyston Books, Inc. These novels narrate the lives of a poor ...
(Date:12/6/2016)... ... December 06, 2016 , ... Men with gum disease ... of serious health problems, such as cardiovascular illness, according to research cited in ... Hills Periodontics & Dental Implant Center notes that the correlation between periodontal disease ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016   Arena Pharmaceuticals, Inc. ... it has completed enrollment in the ralinepag phase 2 ... targeting the prostacyclin pathway for the treatment of pulmonary ... at sites globally. "This marks an important ... of our strategic focus on our pipeline," said ...
(Date:12/7/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) has launched Diplomat Specialty Infusion Group, ... Professional, BioRx, MedPro Rx, and XAS Infusion Suites. To ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ... we continue to build on the work we have done, we ...
(Date:12/7/2016)... 2016   Rx Savings Solutions has partnered with ... its Public Employees Insurance Agency (PEIA) to offer more than ... healthcare software, ultimately saving money on their prescriptions. ... members with access to our software that will alert them ... therapy can be found," says Michael Rea , founder ...
Breaking Medicine Technology: