Navigation Links
A reduction in BMI improves insulin sensitivity in obese teens
Date:6/4/2013

Obese teenagers who reduced their body mass index (BMI) by 8 percent or more had improvements in insulin sensitivity, an important metabolic factor related to the later development of type 2 diabetes. The teens followed a family-based, lifestyle-modification weight loss program that offers the potential to become a broader model.

BMI is a measure of body weight adjusted for height.

"This threshold effect that occurs at 8 percent suggests that obese adolescents don't need to lose enormous amounts of weight to achieve improvements," said pediatric endocrinologist Lorraine Levitt Katz, M.D., of the Diabetes Center for Children at The Children's Hospital of Philadelphia. "The improvements in insulin sensitivity occurred after four months of participating in a lifestyle-modification program."

The findings appeared online on May 24 in The Journal of Pediatrics. The first author is Pamela Abrams, M.D., a member of the study team while at Children's Hospital, and currently at St. Luke's Center for Diabetes and Endocrinology, Center Valley, Pa. Another co-author from Children's Hospital is psychiatrist Robert I. Berkowitz, M.D., the principal investigator of a federally sponsored clinical trial of weight loss treatments, from which the researchers analyzed data for the current study.

The study team analyzed results in 113 primarily urban adolescents, aged 13 to 17, of whom 81 percent were female, and 62 percent were African American. At the start of the study, their mean BMI was 37.1, placing them in the severely obese range. None had type 2 diabetes, but their obesity placed them at high risk to develop the disease in the future.

An important goal of the study was to determine the threshold of weight loss that significantly impacted insulin sensitivity, glucose tolerance and the presence of metabolic syndrome (MS). MS, as well as abnormal values in insulin sensitivity and glucose tolerance, is associated with the development of type 2 diabetes. In type 2 diabetes, the body is unable to produce enough, or to properly use, insulin. Improved insulin sensitivity reflects a better ability to process insulin.

The main finding of the current study was a significant improvement in all measures of insulin sensitivity. There was also a trend toward improvement in metabolic syndrome.

The threshold of 8 percentthe level at which a decreased BMI showed improved insulin sensitivitywas consistent with results found previously in adults. Importantly, said Abrams, "while the ideal goal is to achieve normal weight levels, you don't need to be skinny to see improvements. This 8 percent reduction in BMI is achievable, and BMI is easy for primary care physicians to track." (By factoring in both weight and height, BMI is a more useful measurement than simply weight alone.)

The weight loss program, explained Berkowitz, used family-based lifestyle modification. Clinicians taught the teens and adults about healthful eating habits and encouraged them to increase physical activities, such as walking, climbing stairs and engaging in sports. Some of the teens used portion-controlled, prepackaged foods, while others ate regular food but followed a calorie-restricted, nutritionally balanced diet.

The teens attended weekly group counseling meetings, separately from the parents, who had their own weekly group meetings. Group leaders encouraged parents to model healthful behavior for their children, and to support the teens' behavior changes. "This study reinforces the importance of behavior changeadopting healthy eating habits and getting more physical activityin achieving weight loss in adolescents," added Berkowitz, the director of CHOP's Weight and Eating Disorders Research Program.

The authors added that this study was relatively small, and that future research in larger numbers of patients is needed to reveal longer-term results, and to investigate further effects on adolescent metabolism and health. "These are preliminary results," said Katz, "but this is the first study to identify a threshold effect for these improvements, and later studies can build on this one. Having more evidence about reasonable weight loss goals will help researchers develop more effective programs for teenage patients. "


'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Popularity of Tellurex Corporation's New Tea Candle Heat-Powered tPOD1 Emergency Power Generator Celebrated with Price Reduction
2. Narconon Releases Early Study of Delaware Prison Program, Demonstrating Crime Reduction Consistent with More Recent Narconon Results
3. Dr. Philip Miller Now Performing MicroRhinoplasty for Nasal Hump Reduction
4. Salt Institute: IOM Admits Sodium Reduction May Cause Harm, More Studies Needed
5. EcoVim Organic Food Waste Reduction & Conversion System to Debut at Westchester County’s Food Rescue Forum
6. EcoVim Food Waste Reduction & Conversion System to Debut at Columbia Business School Symposium
7. Michigan Lake Launches Aggressive Eurasian Watermilfoil Reduction Project
8. Novel Drug Treatment Quickly Reverses Alzheimer’s Disease Resulting in a Significant Reduction in Assisted Living Expenses
9. Roadmap to 25 percent reduction in premature deaths From RHD in the under 25s by 2025 published
10. EcoVim Organic Food Waist Reduction System to Debut at the MASSRECYCLE Conference
11. Nouvelle Research, Inc. studies show chronic inflammation reduction through NRF2 Upregulation and NF-kB Downregulation, Cur-OST® Supplements Positively Impact Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... (PRWEB) , ... April 29, 2017 , ... Phytomer USA ... As a Phytomer Account Manager, Smith’s role is to provide excellent customer ... that make up The Phytomer Group. Smith comes to Phytomer with a wealth of ...
(Date:4/28/2017)... ... April 28, 2017 , ... The National Campaign to ... the Access to Contraception for Women Servicemembers and Dependents Act of 2017. The ... will help to ensure that all members of the Armed Forces receive high ...
(Date:4/28/2017)... ... April 28, 2017 , ... Horizon Blue Cross Blue Shield of New Jersey ... “A” and its outlook as “stable.” At the same time, the ratings agency cautioned ... recent years, dip below “capital adequacy” thresholds required for its strong rating. , “Horizon ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Radiology Business Management ... officers for 2017-2018. The annual board election process has been in place since the ... , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... liability could substantially improve drug safety and minimize the cost of development. In ... ion channel inhibition using cell lines and for cardiac toxicity using induced pluripotent ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  Novartis today announced the publication ... Lung, and Blood Institute (NHLBI) of the National ... patients with treatment-naïve severe aplastic anemia (SAA) achieved ... eltrombopag at the initiation of and concurrently with ... three sequential treatment groups, or cohorts. Cohort 3 ...
(Date:4/18/2017)... MINNEAPOLIS , April 18, 2017 Cogentix ... focused on providing the Urology, Uro/Gyn and Gynecology markets ... for the first quarter ended March 31, 2017 after ... The Company will host a conference call ... day on Tuesday, May 2, 2017 at 4:30 p.m. ...
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., developer ... series to be presented at the 2017 National Kidney ... today and continues through April 22. Physicians will present ... used to assess risk for acute kidney injury (AKI) ... failure (ADHF). Elevated levels of TIMP-2 ...
Breaking Medicine Technology: