Navigation Links
A rare association: Non-islet cell tumor hypoglycemia

Non-islet cell tumor hypoglycemia (NICTH) is a rare association between spontaneous hypoglycemia and tumors derived from tissues other than the pancreatic islets. It was initially associated with abdominal soft tissue sarcomas, although other tumor types have been described.

The pathogenesis of hypoglycemia in NICTH may involve a variety of mechanisms, including excessive consumption of glucose by what is typically a large tumor; inadequate production of counterregulatory hormones, such as growth hormone or cortisol; or ectopic or abnormal secretion of insulin or insulin-like growth factor-2 (IGF-II) and IGF-binding proteins. This last mechanism seems to be the most frequent and best characterized in patients with typical NICTH. Insulin secretion by the non-beta-cell tumor is, however, extremely rare and most cases published are secondary to secretion of an incompletely processed IGF-II by the tumor (big IGF-II), which acts as an insulin-like factor in the insulin receptors, causing hypoglycemia

A research team led by Dr. Robert Diaz and his team from Spain have written an article to be published on March 28, 2008 in the World Journal of Gastroenterology. A 74-year-old patient with advanced sigmoid cancer, who suffered recurrent bouts of fasting hypoglycemia presented to them. The diagnostic work-up finally revealed the ectopic production of insulin by the tumor. The possible simultaneous presence of a pancreatic insulin-secreting primary tumor (insulinoma) was ruled out by different laboratory and imaging tests.


Contact: Jing Zhu
World Journal of Gastroenterology

Page: 1

Related medicine news :

1. Grocery Manufacturers Association: US Food & Drug Administration and European Food Safety Authority Affirm Safety of Certified Food Dyes
2. Grocery Manufacturers Association: Canadian Risk Assessment Reaffirms Safety of Bisphenol A (BPA) for Adults and Children
3. Texas Health Care Association: New Report on Long Term Care Workforce Spotlights Need to Boost Texas Medicaid Rates
4. AUDIO from Medialink and the National Lipid Association: Whats Your Triglycer-IQ?
5. A new weapon for attacking tumor invasion and metastasis
6. Ability to track stem cells in tumors could advance cancer treatments
7. Primary tumors can drive the growth of distant cancers
8. Primary Tumors Fuel Growth of Cancer Cells
9. Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
10. Cancer-killing viruses influence tumor blood-vessel growth
11. Solid tumor cells not killed by radiation and chemotherapy become stronger
Post Your Comments:
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
Breaking Medicine Technology: