Navigation Links
A protein’s role in helping cells repair DNA damage
Date:11/1/2012

BUFFALO, N.Y. -- In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.

The research appeared online on Oct. 30 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.

TFIIB, short for "transcription factor II B," is a protein that binds to DNA in cells to initiate the process of transcription, which is critical for building new proteins.

When DNA damage occurs, TFIIB is altered in a way that halts general transcription, enabling a cell to give priority to repair, the researchers found. With the shut-down in effect, cells are able to prioritize the important functions carried out by a tumor-suppressing protein called p53, said lead author Jayasha Shandilya, a postdoctoral researcher in UB's Department of Biological Sciences.

"P53 is a very important protein in humans and other multicellular organisms," Shandilya said. "It is called the 'guardian of the genome' because it helps maintain the stability of the genome."

About half of cancer cases involve a mutation or deletion of the p53 gene. When DNA is damaged, it activates p53, which not only stimulates the DNA repair pathway, but also triggers the synthesis of proteins that stop cells from dividing before problems are fixed, she said. In cases where the damage is irreparable, p53 initiates apoptosis, a process of programmed cell death.

In PNAS, Shandilya and colleagues report that for normal transcription to occur, TFIIB must undergo a process called phosphorylation, in which a phosphate group is attached to the protein.

But when the scientists studied cells treated with DNA damaging agents, they found that TFIIB was dephosphorylated, preventing general transcription and enabling the cells to focus resources on helping p53 carry out its tumor suppressing functions. In essence, p53 can bypass
'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
2. Coach could be key in helping stroke patients
3. Playfulness May Be Natures Way of Helping Romance Bloom: Study
4. Helping Alzheimers patients stay independent
5. Employment Key to Helping Veterans Adjust to Life Back Home
6. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
7. Scientists create endless supply of myelin-forming cells
8. Stem Cells to Cartilage? Promising Results Seen in Mice
9. Scientists decode software instructions of aggressive leukemia cells
10. New options for ease and accuracy in extraction of rare cells or separating blood
11. Stimulating brain cells with light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... (PRWEB) May 20, 2013 FixturesAndDisplays.com, the ... comprehensive selection of high-quality retail clothing display options to ... and upscale retailers. Their expansive product line includes ... broad range of mannequin options. Recently ... its most popular models in reformulated “green” versions. ...
(Date:5/20/2013)... As a mother to three children, Lacy Arnold knows firsthand how ... fit, healthy lifestyle. She also knows the pains and frustrations associated ... of bricks about a year after giving birth to my first ... had lost control of my health and weighed over 200 pounds ... energy to care for my sweet little girl, and I was ...
(Date:5/20/2013)... 2013 Today is the last day ... Answers Webinar tomorrow. Job seekers cannot afford to ... career coach, will show job seekers what hiring managers ... also learn the perfect interview answers to the four ... that will get them hired. Job seekers will be ...
(Date:5/19/2013)... Alonso Krangle LLP, an experienced plaintiffs’ ... York woman in a Paternity Petition against Herschel ... (NFL). According to an April 23rd filing in New ... of paternity, order of support and further relief as may ... Walker. (Docket No. P-18821-13) , Herschel Walker, is a ...
(Date:5/19/2013)... 2013 The special introductory offer for ... end soon. "We are so excited to introduce our ... Sublime Beauty®. "It is a pleasure to use, it ... it also moisturizes the skin. One of the powerful ... that is very successful in clinical studies." , Collagen ...
Breaking Medicine News(10 mins):Health News:FixturesAndDisplays.com Offers Line of ‘Green’ Mannequins for Retail Displays 2Health News:FixturesAndDisplays.com Offers Line of ‘Green’ Mannequins for Retail Displays 3Health News:New Program Helps Busy Moms Become Healthier, Lose Weight, and Feel Great 2Health News:Today Is the Last Day to Register for Tomorrow’s Perfect Interview Answers Webinar From Career Confidential 2Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 2Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 3
... 10, 2011 In 1980 in the United States, approximately ... By 2007 that figure had increased to 14%. Women over ... with trisomy 21. In a study published online today in ... researchers from the Sequenom Center for Molecular Medicine confirmed that ...
... like shots or needles, you,re in luck. New research published ... gives the development of new oral vaccinations a shot in ... mice. In addition, this research report also offers a tantalizing ... even if direct injections into the body fail to cause ...
... HealthDay Reporter , WEDNESDAY, Feb. 9 (HealthDay News) -- Surgery ... cord birth defect known as spina bifida may be most ... groundbreaking -- research suggests. When successful, the surgery could ... not, experts say, since twice as many spina bifida-affected children ...
... , THURSDAY, Feb. 10 (HealthDay News) -- Low ... associated with higher rates of obesity, researchers report. The ... in cities tend to be thinner because they have more ... have to drive most everywhere they go. For this ...
... FRANCISCO (February 10, 2011) In a study to ... (SMFM) annual meeting, The Pregnancy Meeting , in San ... rats, the use of magnesium sulfate (Mg) significantly reduced ... maternal infection. Magnesium sulfate is sometimes used during ...
... 10, 2011) In a study to be presented today ... Pregnancy Meeting , in San Francisco, researchers will present findings ... mothers in situations when labor has to be induced, that ... There are many reasons that labor may need to ...
Cached Medicine News:Health News:Noninvasive test for trisomy 21 closer at hand 2Health News:Salivary glands as organs of immunity: New research makes oral immunization easier to swallow 2Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 2Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 3Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 4Health News:Study finds magnesium sulfate may offer protection from cerebral palsy 2Health News:When first-time mothers are induced, breaking the amniotic membrane shortens delivery time 2
(Date:5/18/2013)... , May 18, 2013 Faruqi & ... is investigating potential securities fraud at AVEO Pharmaceuticals, ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... its executives violated federal securities laws by issuing ... Phase III drug trials for Tivopath (tivozanib) (titled ...
(Date:5/17/2013)... 2013  Sorrento Therapeutics, Inc. (OTCBB: SRNE; or ... Small Business Technology Transfer Research (STTR) grant (#1R42AI098182-02) ... Diseases (NIAID), a division of the National Institutes ... human antibody therapeutics to combat Staphylococcus aureus ... including methicillin-resistant S. aureus (MRSA), was ...
(Date:5/17/2013)... 2013  Sony Biotechnology Inc. ("Sony") today announced the launch ... 130um sorting chip.  Sony will also be exhibiting its newly ... Cell Sorter, the EC800 flow cytometer, and new SP6800 Spectral ... which will be held at the San Diego ... , from May 20 - 22.  ...
Breaking Medicine Technology:Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Sony Delivers New Technology for Science to CYTO 2013 2
... Club (FC) Barcelona, FC Barcelona Foundation, and ... three-year partnership today to energize the global fight to ... life-saving vaccines.  Bill Gates, co-chair of the Bill & ... Rosell and Manager Josep Guardiola, announced the partnership at ...
... China, July 28, 2011 /PRNewswire-Asia/ -- China Kanghui Holdings (NYSE: ... domestic developer, manufacturer and marketer of orthopedic implants in China, ... 2011 financial results on August 16, 2011, before the market ... 8:00 a.m. ET on August 16, 2011 to discuss second ...
Cached Medicine Technology:Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 2Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 3China Kanghui Holdings to Report Second Quarter 2011 Financial Results on August 16, 2011 2
Store microscope slides with ease, speed, efficiency....
... drawers for just about everything imaginable that might ... Each box is designed for long term storage ... of wood over metal systems is overlooked, while ... subtle kind of desiccator and insulator, providing an ...
A prepared Microscope Slide Cataloging and Storage System....
... resistant, plastic covered corrugated boxes interlock ... up to 500 lbs of overhead ... accommodates 2000 slides or 500 tissue ... requirements. Come unassembled boxes require minimal ...
Medicine Products: