Navigation Links
A protein’s role in helping cells repair DNA damage
Date:11/1/2012

BUFFALO, N.Y. -- In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.

The research appeared online on Oct. 30 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.

TFIIB, short for "transcription factor II B," is a protein that binds to DNA in cells to initiate the process of transcription, which is critical for building new proteins.

When DNA damage occurs, TFIIB is altered in a way that halts general transcription, enabling a cell to give priority to repair, the researchers found. With the shut-down in effect, cells are able to prioritize the important functions carried out by a tumor-suppressing protein called p53, said lead author Jayasha Shandilya, a postdoctoral researcher in UB's Department of Biological Sciences.

"P53 is a very important protein in humans and other multicellular organisms," Shandilya said. "It is called the 'guardian of the genome' because it helps maintain the stability of the genome."

About half of cancer cases involve a mutation or deletion of the p53 gene. When DNA is damaged, it activates p53, which not only stimulates the DNA repair pathway, but also triggers the synthesis of proteins that stop cells from dividing before problems are fixed, she said. In cases where the damage is irreparable, p53 initiates apoptosis, a process of programmed cell death.

In PNAS, Shandilya and colleagues report that for normal transcription to occur, TFIIB must undergo a process called phosphorylation, in which a phosphate group is attached to the protein.

But when the scientists studied cells treated with DNA damaging agents, they found that TFIIB was dephosphorylated, preventing general transcription and enabling the cells to focus resources on helping p53 carry out its tumor suppressing functions. In essence, p53 can bypass the need for TFIIB phosphorylation to activate transcription of its target genes, which are vital for DNA damage response.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert

Related medicine news :

1. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
2. Coach could be key in helping stroke patients
3. Playfulness May Be Natures Way of Helping Romance Bloom: Study
4. Helping Alzheimers patients stay independent
5. Employment Key to Helping Veterans Adjust to Life Back Home
6. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
7. Scientists create endless supply of myelin-forming cells
8. Stem Cells to Cartilage? Promising Results Seen in Mice
9. Scientists decode software instructions of aggressive leukemia cells
10. New options for ease and accuracy in extraction of rare cells or separating blood
11. Stimulating brain cells with light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: