Navigation Links
A protein’s role in helping cells repair DNA damage
Date:11/1/2012

BUFFALO, N.Y. -- In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.

The research appeared online on Oct. 30 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.

TFIIB, short for "transcription factor II B," is a protein that binds to DNA in cells to initiate the process of transcription, which is critical for building new proteins.

When DNA damage occurs, TFIIB is altered in a way that halts general transcription, enabling a cell to give priority to repair, the researchers found. With the shut-down in effect, cells are able to prioritize the important functions carried out by a tumor-suppressing protein called p53, said lead author Jayasha Shandilya, a postdoctoral researcher in UB's Department of Biological Sciences.

"P53 is a very important protein in humans and other multicellular organisms," Shandilya said. "It is called the 'guardian of the genome' because it helps maintain the stability of the genome."

About half of cancer cases involve a mutation or deletion of the p53 gene. When DNA is damaged, it activates p53, which not only stimulates the DNA repair pathway, but also triggers the synthesis of proteins that stop cells from dividing before problems are fixed, she said. In cases where the damage is irreparable, p53 initiates apoptosis, a process of programmed cell death.

In PNAS, Shandilya and colleagues report that for normal transcription to occur, TFIIB must undergo a process called phosphorylation, in which a phosphate group is attached to the protein.

But when the scientists studied cells treated with DNA damaging agents, they found that TFIIB was dephosphorylated, preventing general transcription and enabling the cells to focus resources on helping p53 carry out its tumor suppressing functions. In essence, p53 can bypass the need for TFIIB phosphorylation to activate transcription of its target genes, which are vital for DNA damage response.


'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert

Related medicine news :

1. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
2. Coach could be key in helping stroke patients
3. Playfulness May Be Natures Way of Helping Romance Bloom: Study
4. Helping Alzheimers patients stay independent
5. Employment Key to Helping Veterans Adjust to Life Back Home
6. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
7. Scientists create endless supply of myelin-forming cells
8. Stem Cells to Cartilage? Promising Results Seen in Mice
9. Scientists decode software instructions of aggressive leukemia cells
10. New options for ease and accuracy in extraction of rare cells or separating blood
11. Stimulating brain cells with light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
Breaking Medicine Technology: