Navigation Links
A promising target for developing treatments against Parkinson's disease
Date:8/23/2010

K2 mutations," says Ted Dawson, M.D., Ph.D., professor of neurology and physiology and scientific director of the Johns Hopkins Institute for Cell Engineering.

The two drugs that blocked LRRK2 and prevented death of nerve cells in mice with Parkinson's disease both had similar chemical structures. "One could envision generating compounds around that core structure to develop a relatively selective and potent inhibitor of LRRK2," says Dawson.

Dawson is collaborating with researchers at Southern Methodist University to design more specific inhibitors of LRRK2 and the group plans to license this technology. Once they identify promising candidate drugs, those candidates still will have to be tested for toxic side effects. The drugs' approval by the FDA for use in humans may still be many years away.

Says Dawson, treatments developed specifically against LRRK2 may even be able to treat other forms of Parkinson's disease those not caused by LRRK2 alterations as there may be several alterations in different proteins that can lead Parkinson's disease.

"We're curing Parkinson's disease in a mouse and now we have to discover drugs that actually work in human neurons. Then we'll hopefully be able to make the leap forward to get a treatment to work in humans," says Dawson.


'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Natural lung material is promising scaffold for engineering lung tissue using embryonic stem cells
2. Depression overlooked in patients with hepatitis C; compromising HCV therapy
3. BRAF inhibitor shows promising preclinical activity against melanoma
4. New promising therapy against systemic sclerosis
5. Is the current recession compromising hospital quality?
6. Peaches, plums induce deliciously promising death of breast cancer cells
7. U of A discovery offers promising research for spinal-cord injury treatments
8. Study identifies promising treatment for aggressive lymphoma
9. Monitoring and control can limit side effects of promising cancer drugs
10. Team finds promising new drug target for Alzheimers disease
11. Promising hormone may help reduce malnutrition in gastric cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... online in The Gerontologist reports ... associated with a decrease in anxiety about death and ... over their lives. In particular, listening to gospel music ... and an increase in sense of control. , These ... men, and individuals of both low- and high-socioeconomic status. ...
(Date:4/18/2014)... made a brain-related discovery that could revolutionize doctors, ... discovery opens up the possibility that environmental and/or ... brain activity that the researchers have identified as ... of Neuroscience has just published a paper ... professor of psychology and his doctoral student John ...
(Date:4/17/2014)... who show signs of chronic inflammation in non-cancerous prostate ... having prostate cancer than those with no inflammation, according ... from the Johns Hopkins Kimmel Cancer Center. , The ... for men with so-called high-grade prostate cancer those ... indicating the presence of the most aggressive and rapidly ...
(Date:4/17/2014)... Biology and Medicine a multidisciplinary research team ... in the Institute of Genomic Biology (IGB) on ... describe their recent work on subcellular redox homeostasis. ... functions including energy metabolism, signaling, and transcriptional processes. ... cellular behavior, redox status has been recognized as ...
(Date:4/17/2014)... biology team has created a new technology for ... could travel the body and selectively target cancer ... biological devices that monitor and modify human physiology ... However, no existing technology enabled bioengineers to build ... and respond in a customized fashion. , "The ...
Breaking Medicine News(10 mins):Health News:Religious music brings benefit to seniors' mental health 2Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2
... making a case for a new eating disorder she calls ... nervosa in that both syndromes involve eating, then trying to ... the amount of food consumed and the way people compensate ... or even small amounts of food and then purge, often ...
... Mich., Sept. 4 EaglePicher Corporation,(EaglePicher) today announced ... sell EaglePicher Boron, LLC (EP Boron) to,Ceradyne, Inc. ... in Quapaw, Oklahoma, has produced enriched boron,isotopes and ... and hazardous materials industries. Its products include,isotope B11, ...
... exposure to acidic drinks and foods permanently destroys,enamel, ... may seem like harmless snacks and beverages, but improper,consumption ... to,teeth. It,s known as tooth erosion, and an online ... revealed that dentists feel tooth,erosion is more common today ...
... separate laboratory benches across the country has discovered a new ... The technique, which holds promise for disinfecting blood for transfusions, ... fractions of a second. , Johns Hopkins University student Shaw-Wei ... park with his father that the idea was born. ...
... Council (NPC) announced today a new strategic focus ... While NPC,s overarching mission remains to sponsor ... pharmaceuticals and the,clinical and economic value of pharmaceutical ... for NPC. NPC will be reorganizing and hiring,additional ...
... (NYSE: EW ), a world leader in products ... participate in the,Bear Stearns 20th Annual Healthcare Conference at ... Monday, September 10, 2007. Michael A. Mussallem, Edwards ... attendees at 2:30 p.m. ET. A live webcast,of the ...
Cached Medicine News:Health News:University of Iowa professor identifies new eating disorder 2Health News:EaglePicher Corporation Completes Transaction to Sell EaglePicher Boron, LLC to Ceradyne, Inc. for $69 Million 2Health News:Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion 2Health News:Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion 3Health News:Laser blasts viruses in blood 2Health News:National Pharmaceutical Council Announces New Strategic Focus, Search for New Leadership 2Health News:Edwards Lifesciences to Present at the Bear Stearns 20th Annual Healthcare Conference 2
(Date:1/14/2014)... Mass. , Jan. 14, 2014 HeartWare ... leading innovator of less invasive, miniaturized circulatory support technologies ... today announced that it expects revenues for the fourth ... expected full-year 2013 revenues to approximately $208 million. ...
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
(Date:1/14/2014)... , Jan. 14, 2014 NineSigma , ... hold its Innovation Leadership Summit , May 14-16, ... Cleveland Ohio . ... and organizations committed to breakthrough achievements through open innovation. ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... Nov. 1 Obesity is common in,children with ... of a,shortened life expectancy., More than 25 ... are overweight or obese, say researchers from The ... a study,released in the current issue of Pediatrics. ...
... the 2nd Annual International Workshop on Hepatitis C ... ... Researchers from Enanta,Pharmaceuticals today presented data on novel Hepatitis C ... favorable pre-clinical pharmacokinetic properties with the potential,for once-daily dosing in ...
Cached Medicine Technology:Obesity Common in Children with Heart Disease 2Obesity Common in Children with Heart Disease 3Potent Hepatitis C Virus Inhibitors Show Efficacy and Potential for Once Daily Dosing in Preclinical Studies 2
Inquire...
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Single-action scissors offer fine-pointed, sharp dissecting jaws to facilitate a partial cut in the cystic duct in preparation for a cholangiogram. They are tapered at the tip for greater visualizati...
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Medicine Products: