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A promising clinical trial to reduce the severity of autistic disorders
Date:12/12/2012

sm Rating Scale (CARS) behavioural scale was used to rate the severity of the disorders, based on videos of the children's behaviour during an activity led by a caregiver. The films were analysed with the assistance of their parents. A rating is obtained from the analysis as follows: if the rating is between 30 and 36, the child suffers from a moderate or average disorder; if the rating is higher than 36, the child is severely autistic.

Two other indicators were used to assess the severity of the disorders: the Clinical Global Impressions (CGI) clinical diagnosis, and the Autism Diagnostic Observation Schedule Generic (ADOSG) indicator combining assessment criteria such as social interaction and communication.

Dr. Lemonnier explained the case of a 6-year-old boy: "Prior to the treatment, the child presented with low language abilities and little social interaction, was hyperactive and exhibited constantly-combative behaviour. After three months of treatment, his parents, teachers, the hospital nursing staff and his friends at school all said that he was participated more, particularly in the games proposed by the psychologist. His attention and eye contact also improved."

"Even though it is not curative, the diuretic reduced the severity of most of the children's autistic disorders. According to the children's parents, they are more "present"", added Yehezkel Ben-Ari.

Given the population's heterogeneity, the researchers assume that the treatment could act differently depending on the severity of the autistic disorders. By forming groups based on severity, the results suggest that the treatment would be more effective in the least seriously-affected children.

As a result, the researchers have filed an authorisation request for a multi-centre European clinical trial in order to determine more precisely the population concerned by this treatment and ultimately obtain a marketing authorisation for this therapy. This test is s
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Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

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