Navigation Links
A prognostic and predictive biomarker for nonsmall cell lung cancer
Date:6/1/2010

r periods than those from patients with lower expression of the protein.

Besides the correlation found between cofilin and patient survival, the group also investigated whether cofilin levels could provide any clues on tumor aggressiveness. According to Dr. Klamt, "cofilin is a protein associated with cell mobility. We know that poor prognosis correlates with the ability of cells to move to generate metastasis. Thus, it seemed only reasonable that cells with lower levels of this protein would be less aggressive while higher levels would provide a more aggressive behavior." Indeed, the group tested six human cell lines of 3 major types of NSCLC and found that the types with higher levels of cofilin presented a greater potential to invade other sites in the body, which indicates a more aggressive behavior. "For patients," explains Dr. Klamt, "this finding indicates that lower levels of cofilin translate into lower chances to develop metastasis, which ultimately leads to a better prognosis."

The group also found that high levels of cofilin correlate with resistance to certain anticancer drugs, especially cisplatin and carboplatin, which have long been used for treating NSCLC. Cisplatin-based chemotherapy is the standard first-line treatment for patients at an early stage and with good performance. Nevertheless, only some will respond to this treatment. Now cofilin levels may be used to distinguish between responders and non-responders. This new finding may have great impact on survival rates, as potential non-responders may benefit from different treatment options that would not be available otherwise.


'/>"/>

Contact: Marcia Triunfol
mtriunfol@gmail.com
55-248-142-0202
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related medicine news :

1. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
2. Springer publishes new journal in predictive, preventive and personalized medicine
3. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
4. Existence Genetics is Pioneering the Field of Predictive Medicine - Nexus Technologies Critical in Understanding and Preventing Deadly Disease
5. Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinsons Disease Biomarker Pipeline
6. Biomarker could help doctors tailor treatment for rheumatoid arthritis
7. TGen analysis identifies biomarkers for diabetic kidney failure
8. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
9. Personalizing cancer: Creating biomarkers from tumor DNA
10. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
11. Reliable biomarkers needed for early detection of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 29, 2015 , ... Talking About Your Product Pipeline:, How FDA ... – 3:00 p.m. EDT, http://www.fdanews.com/productpipeline , When a company has a product ... say about it is tightly regulated by the FDA. , At the same time, ...
(Date:7/28/2015)... ... ... Sports, a specialty sports retailer and a premiere destination for dedicated athletes and active ... has served on the Board of Directors for City Sports since 2008 and spent ... previous tenures as Chairman and CEO of Golfsmith International Holdings, Inc., Chairman and CEO ...
(Date:7/28/2015)... IL (PRWEB) , ... July 29, 2015 , ... The ... involvement of automakers. This would allow insurers to access the on-board vehicle data and ... been reticent when it comes to sharing vehicle data. However times are changing and ...
(Date:7/28/2015)... ... ... ProFont is back with a whole new stylized and cursive animated font ... a hand drawn feel all with a click of a mouse. With ProFont: Cursive ... upper and lowercase alphabet, special characters, numbers, and stylized compound tools. With easy to ...
(Date:7/28/2015)... ... 2015 , ... A skin cancer screening program offered by the American Society ... for “helping to make the world a better place.” , The Choose Skin Health ... Society of Association Executives. Power of A recognizes organizations annually that “distinguish themselves with ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 2Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 3Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 4Health News:City Sports Names Marty Hanaka CEO 2Health News:General Motors Engaging Insurance Partners for the Connected Car 2Health News:General Motors Engaging Insurance Partners for the Connected Car 3Health News:Announcing ProFont Cursive from FCPX Effects developer Pixel Film Studios 2Health News:ASDS Skin Cancer Program Honored 2Health News:ASDS Skin Cancer Program Honored 3
... From new flu A H1N1 to earthquakes and fires, ... potential public health emergenciesLOS ANGELES, May 26 The ... a workshop, titled "Managing a Public Health Crisis at ... managers to effectively respond to public health emergencies. More ...
... expert Stewart Gandolf has authored a DVD designed to help doctors, ... grow their revenues despite the recession. , ... Irvine, ... a new DVD designed to help doctors, hospitals and other healthcare ...
... China Kangtai Cactus,Biotech Inc. (the "Company") (OTC ... manufacturer and marketer of a variety of,cactus-based ... they are,preparing to significantly expand its shareholder ... an internationally-recognized investor,relations firm. The Company ...
... with Philips QLAB ultrasound software now availableINDIANAPOLIS, May ... is pleased to announce the commercial availability of ... 4.0.2. Featuring the integration with QLAB advanced ... release from ProSolv has been designed to enhance ...
... 2009 -- The World Health ... today announced the launch of a Joint Programme on ... fight cancer in the developing world. , The groundbreaking ... burden and its projected increase. Latest statistics indicate that ...
... in the sun reduce the risk of developing multiple sclerosis? ... Bridget Bagert and Dennis Bourdette highlight recent advances in potential ... the body to recognize itself. The immune system attacks and ... were a foreign body or infection. Vitamin D, which is ...
Cached Medicine News:Health News:County and City Leaders Coordinate to Just Be Ready 2Health News:Medical Marketing DVD Helps Doctors and Hospitals Win Patients Despite The Recession 2Health News:China Kangtai Cactus Biotech Announces Goal to Expand and Enhance Shareholder Communication 2Health News:ProSolv Version 4.0.2 Makes Commercial Debut at ASE 2Health News:WHO-IAEA join forces to fight cancer 2
(Date:7/29/2015)... According to a new market ... Trends & Forecasts (2015-2020) , published by Mordor Intelligence, ... 2.85 billion by the end of 2020, with ... globally accounting for more than 36% of the global ... expected to grow at a CAGR of 44.6% during ...
(Date:7/28/2015)... IRVINE, Calif., July 28, 2015  Edwards Lifesciences Corporation (NYSE: ... of heart valves and hemodynamic monitoring, today reported net ... million, or $1.02 per diluted share.  Adjusted net income ... per diluted share, compared to $0.88 per diluted share ... period, GAAP net income was $5.09 per diluted share, ...
(Date:7/28/2015)... LOUIS, July 28, 2015  Express Scripts Holding Company ... income attributable to Express Scripts stockholders of $600.1 million, ... share, as detailed in Table 4, were $1.44 for ... is clear many companies across healthcare are validating the ... and Chief Executive Officer. "But, what matters most is ...
Breaking Medicine Technology:New Approaches and Technical Advances by Major Players Like Novartis, Merck KGaA, Pfizer, GlaxoSmithKline and Others to Elevate the Global Therapeutic Vaccines Market 2New Approaches and Technical Advances by Major Players Like Novartis, Merck KGaA, Pfizer, GlaxoSmithKline and Others to Elevate the Global Therapeutic Vaccines Market 3Edwards Lifesciences Reports Second Quarter Results 2Edwards Lifesciences Reports Second Quarter Results 3Edwards Lifesciences Reports Second Quarter Results 4Edwards Lifesciences Reports Second Quarter Results 5Edwards Lifesciences Reports Second Quarter Results 6Edwards Lifesciences Reports Second Quarter Results 7Edwards Lifesciences Reports Second Quarter Results 8Edwards Lifesciences Reports Second Quarter Results 9Edwards Lifesciences Reports Second Quarter Results 10Edwards Lifesciences Reports Second Quarter Results 11Edwards Lifesciences Reports Second Quarter Results 12Edwards Lifesciences Reports Second Quarter Results 13Edwards Lifesciences Reports Second Quarter Results 14Edwards Lifesciences Reports Second Quarter Results 15Edwards Lifesciences Reports Second Quarter Results 16Edwards Lifesciences Reports Second Quarter Results 17Edwards Lifesciences Reports Second Quarter Results 18Edwards Lifesciences Reports Second Quarter Results 19Edwards Lifesciences Reports Second Quarter Results 20Edwards Lifesciences Reports Second Quarter Results 21Edwards Lifesciences Reports Second Quarter Results 22Edwards Lifesciences Reports Second Quarter Results 23Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 2Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 3Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 4Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 5Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 6Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 7Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 8Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 9Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 10Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 11Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 12
... - Oncolytics,Biotech Inc. ("Oncolytics") announces that a poster ... New York, entitled "In Vivo Synergy between,Oncolytic Reovirus ... to be presented today at the American,Association for ... The meeting runs from April 14-18, 2007. , ...
... 17, 2007 - Cougar Biotechnology,Inc. (OTCBB:CGRB) today announced ... the Company's prostate cancer drug candidate CB7630,(abiraterone acetate) ... (AACR) Annual Meeting in Los Angeles, California.,The data ... of a,special session, Phase II Proof of Concept ...
Cached Medicine Technology:Oncolytics Biotech Inc. Research Collaborators Demonstrate,Reovirus/Gemcitabine Combination Has Synergistic Effect Against,Human Colon Cancer Cell Lines 2Oncolytics Biotech Inc. Research Collaborators Demonstrate,Reovirus/Gemcitabine Combination Has Synergistic Effect Against,Human Colon Cancer Cell Lines 3Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR,Annual Meeting Late-Breaking Clinical Trials Session 2Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR,Annual Meeting Late-Breaking Clinical Trials Session 3Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR,Annual Meeting Late-Breaking Clinical Trials Session 4Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR,Annual Meeting Late-Breaking Clinical Trials Session 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: