Navigation Links
A prognostic and predictive biomarker for nonsmall cell lung cancer
Date:6/1/2010

r periods than those from patients with lower expression of the protein.

Besides the correlation found between cofilin and patient survival, the group also investigated whether cofilin levels could provide any clues on tumor aggressiveness. According to Dr. Klamt, "cofilin is a protein associated with cell mobility. We know that poor prognosis correlates with the ability of cells to move to generate metastasis. Thus, it seemed only reasonable that cells with lower levels of this protein would be less aggressive while higher levels would provide a more aggressive behavior." Indeed, the group tested six human cell lines of 3 major types of NSCLC and found that the types with higher levels of cofilin presented a greater potential to invade other sites in the body, which indicates a more aggressive behavior. "For patients," explains Dr. Klamt, "this finding indicates that lower levels of cofilin translate into lower chances to develop metastasis, which ultimately leads to a better prognosis."

The group also found that high levels of cofilin correlate with resistance to certain anticancer drugs, especially cisplatin and carboplatin, which have long been used for treating NSCLC. Cisplatin-based chemotherapy is the standard first-line treatment for patients at an early stage and with good performance. Nevertheless, only some will respond to this treatment. Now cofilin levels may be used to distinguish between responders and non-responders. This new finding may have great impact on survival rates, as potential non-responders may benefit from different treatment options that would not be available otherwise.


'/>"/>

Contact: Marcia Triunfol
mtriunfol@gmail.com
55-248-142-0202
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related medicine news :

1. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
2. Springer publishes new journal in predictive, preventive and personalized medicine
3. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
4. Existence Genetics is Pioneering the Field of Predictive Medicine - Nexus Technologies Critical in Understanding and Preventing Deadly Disease
5. Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinsons Disease Biomarker Pipeline
6. Biomarker could help doctors tailor treatment for rheumatoid arthritis
7. TGen analysis identifies biomarkers for diabetic kidney failure
8. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
9. Personalizing cancer: Creating biomarkers from tumor DNA
10. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
11. Reliable biomarkers needed for early detection of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Calif., April 17, 2014 By discovering a new ... after a stroke, researchers at UC Irvine and the ... that may limit or prevent stroke-induced brain damage. , ... fourth-leading cause of death and primary reason for disability ... in a stroke and lets blood-borne material into the ...
(Date:4/17/2014)... 17, 2014 EcoHealth Alliance, a nonprofit organization that ... a comprehensive review today examining the current state of ... review calls for improved global surveillance strategies to combat ... outbreak of Ebola in West Africa that has claimed ... Guinea and Liberia. According to the World Health ...
(Date:4/17/2014)... online has the potential to ward off depression among ... research published online in The Journals of ... . In the article " Internet Use and Depression ... Longitudinal Analysis ," the authors report that Internet use ... percent among their study sample. , Late-life depression ...
(Date:4/17/2014)... April 2014) Population Council scientists and their partners have ... and can prevent the transmission of multiple sexually transmitted ... animals: HIV, herpes simplex virus 2 (HSV-2), and human ... data that the gel is effective against multiple strains ... the vagina against all three viruses of at least ...
(Date:4/17/2014)... April 17, 2014 Meaningful long-term survival is ... of the abdomen when treated with cytoreductive surgery ... a first-of-its-size analysis by physicians at Wake Forest ... the largest reported, single-center experience with cytoreductive surgery ... M.D., and analysis of 20 years, worth of ...
Breaking Medicine News(10 mins):Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Internet use may cut retirees' depression 2Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2
... 25, 2007) George Mason University professor of ... grant from the National Institutes of Health to ... Alzheimer,s disease. His program, "Apolipoprotein, Attention and Alzheimer,s ... and older adults for four years using cognitive, ...
... The Partnership to,Fight Chronic Disease (PFCD) announced today ... all 2008 presidential candidates to address the,country,s chronic disease ... reform will be the most important domestic issue in ... and,Professor and Chair of the Rollins School of Public ...
... National Marrow Donor Program,s Office of Patient Advocacy receives ... to help cancer survivors like Ryan, MINNEAPOLIS, Sept. 25 ... most of his life. Diagnosed with acute,myelogenous leukemia at just ... marrow or cord blood transplant to survive. Ryan received ...
... the, importance of staying active and eating healthy ... Calif., Sept. 25 Blue Cross of,California, collaborating ... Sports, is launching a 14-week statewide mobile,outreach campaign ... to make,healthy lifestyle choices now and in the ...
... Natural Cottage Cheese and NBC 10 Seek the Next Local ... in This Year,s Healthy Lifestyle ... massage,therapist, a 35-year-old administrative assistant, a 41-year-old comedian,and computer help ... teacher have in common? They,re all contestants in,"The Friendship All ...
... results from the randomized, double -blind,placebo -controlled, Phase ... of ZD4054 - a,specific endothelin A (ETA) receptor ... European,Congress of Clinical Oncology (ECCO, 23-27 September, Barcelona). ... in development for the treatment of men with ...
Cached Medicine News:Health News:George Mason University professor receives $2.6 million NIH grant to study Alzheimer's disease 2Health News:Partnership to Fight Chronic Disease Announces 'Ideas for Change' in Health Care 2Health News:Partnership to Fight Chronic Disease Announces 'Ideas for Change' in Health Care 3Health News:Young Twin Cities Boy Shows There is Life After Cancer 2Health News:Blue Cross of California and the California Governor's Council on Physical Fitness and Sports Launch 'Live Like a Champion Tour' 2Health News:Blue Cross of California and the California Governor's Council on Physical Fitness and Sports Launch 'Live Like a Champion Tour' 3Health News:Five Local Residents Vie to be Philadelphia's Biggest 2007 'Local Loser' 2Health News:Five Local Residents Vie to be Philadelphia's Biggest 2007 'Local Loser' 3Health News:Five Local Residents Vie to be Philadelphia's Biggest 2007 'Local Loser' 4Health News:Survival data presented from phase II study of hormone-resistant prostate cancer patients 2
(Date:1/15/2014)... BOSTON , Jan. 15, 2014 Tegra Medical is ... Mark King as its new Chief Executive Officer.  Mark ... in which he has overseen the company,s four facilities in ... and Costa Rica.  Mr. King joined Tegra Medical in 2012 ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
(Date:1/15/2014)... Jan. 15, 2014  According to Millennium Research Group ... intelligence, the United States ... markets will expand moderately through 2022, with embolization ... particular, increasing interest in drug-eluting beads (DEBs) and ...
Breaking Medicine Technology:Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... LOS ANGELES--(BUSINESS WIRE)--Apr 19, 2007 - Abraxis ... results from two pre-clinical studies that,support the ... rich in,cysteine) expression in cancer and Abraxis' ... Association for Cancer Research (AACR) Annual Meeting ...
... Transurethral Resection,is Well Tolerated in Phase 2b Bladder ... --,Spectrum Pharmaceuticals, Inc., today announced results of a ... and the,presentation of preclinical data of SPI (IRL)-1620 ... Association of Cancer,Research, held at the Los Angeles ...
Cached Medicine Technology:Abraxis BioScience Presents Pre-Clinical Findings That Support Role,of SPARC Expression in Cancer and the Role of the Nanoparticle,Albumin Bound (nab) Technology Platform in Targeting the Pathway 2Abraxis BioScience Presents Pre-Clinical Findings That Support Role,of SPARC Expression in Cancer and the Role of the Nanoparticle,Albumin Bound (nab) Technology Platform in Targeting the Pathway 3Abraxis BioScience Presents Pre-Clinical Findings That Support Role,of SPARC Expression in Cancer and the Role of the Nanoparticle,Albumin Bound (nab) Technology Platform in Targeting the Pathway 4Abraxis BioScience Presents Pre-Clinical Findings That Support Role,of SPARC Expression in Cancer and the Role of the Nanoparticle,Albumin Bound (nab) Technology Platform in Targeting the Pathway 5Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 2Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 3Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 4Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 5Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 6Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 7Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting 8
... known as bone Gla protein, is a ... a major component of the noncollagenous bone ... in bone, with a small amount produced ... [1]. During bone formation, newly synthesized osteocalcin ...
... Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced ... and modulates the bioactivity of IGF-I and ... not been completely defined, but the nature ... be involved in glucose regulation and IGF-mediated ...
... factor binding protein 4 (IGFBP-4) is a 24 ... actions of IGF-I and IGF-II. It is also ... weight of 28 kDa. IGFBP-4 has been identified ... numerous cell types, including fibroblasts, neuroblastoma, prostate and ...
... Androstenedione, produced in the adrenal gland and ... testosterone and estrone, both of which may ... relatively weak androgenic activity, estimated at ~(less ... [1]. However, serum androstenedione levels often exceed ...
Medicine Products: