Navigation Links
A potential targets for the prevention or treatment of esophageal carcinoma
Date:10/29/2008

Expression of Livin in fresh esophageal cancer tissues was detected by immunohistochemistry (IHC), Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR), VEGF by Its correlation Western blotting and RT-PCR. Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of Livin and VEGF increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of Livin and VEGF was the most significant. Expression of Livin was positive correlation with VEGF. Over-expression of Livin and VEGF contributes to the pathogenesis of esophageal carcinoma.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor

Ren GS Cancer Institute of Chiongqing Medical University used molecular biology technology to investigate the role of Livin and VEGF in human esophageal carcinoma and analyze its relationship with clinical stages.

In the present study, authors investigated expression of Livin in human esophageal carcinoma and analyze its relationship with clinical stages. The results showed that Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of Livin increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of Livin was the most significant. The results showed that VEGF positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of VEGF increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of VEGF was the most significant.

Taken together, over-expression of Livin and VEGF contributes to the pathogenesis of esophageal carcinoma. Level of VEGF has positive correlation with Livin. The hypothesis has been made that Livin and VEGF played such an inter-enhancement role in the progress of esophageal carcinoma. Inhibitors of Livin and VEGF may be potential targets for the prevention or treatment of human esophageal carcinoma.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. ETHEX Corporation Voluntarily Recalls Three Lots of Dextroamphetamine Sulfate 5mg Tablets Due to the Potential for Oversized Tablets
2. Potential treatment option for severe emphysema under study
3. How to Help Down Syndrome and Other Special Needs Children - Free Booklet and Parenting Course Available This Month From The Institutes for the Achievement of Human Potential
4. Vasculitis Foundation Integrates Education, Outreach and Technology in First-Ever Webinar on Potentially Life-Threatening Disease
5. A potential approach to treatment of hepatitis B virus infection
6. LegalView Warns Proton Pump Inhibitor Patients of Potential Bone Fracture Risk Associated with Drug
7. Measures to assess potential lung injury during ventilation inadequate
8. Malaria prevention reduces anemia and improves educational potential in Kenyan schoolchildren
9. PMC and County Announce Potential Capital Partners for Hospital
10. Announcement Outlines 36 Month Custom Deployment Contract With Potential Revenues Reaching $30 Million Dollars
11. Wake Forest researchers say popular fish contains potentially dangerous fatty acid combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Last year, 43 million ... US Department of Agriculture report. While excess dairy can be caused by several ... Lactose sensitivity is the inability to properly digest lactose, a sugar found in milk ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Carballo ... Jersey and the New York metropolitan region, is embarking on a cooperative charity ... families. , At present, more than two and a half million children in ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Vanderbeck Agency, a ... greater Nassau County region, is embarking on a combined charity effort with the Great ... For the last 25 years, the Great Neck Breast Cancer Coalition has worked to ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Jim Shortridge Agency, ... and business owners, is joining the Teen Recovery Solutions organization in a charity ... A growing number of Oklahoma teens and adolescents face problems from drugs, alcohol, ...
(Date:3/22/2017)... ... March 22, 2017 , ... The ... related services to families and business owners in the greater Nassau County area, ... & Lymphoma Society. , Every 3 minutes, someone in America is diagnosed with ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 A new ... Disinfector™ is the proven ultraviolet-C (UV-C) disinfection solution ... infections (HAIs). Published in the ... Infection Control , the peer-reviewed study of UV-C ... of Vancouver General Hospital and Rochester General Hospital. ...
(Date:3/22/2017)... -- FinancialBuzz.com News Commentary  ... According to a report by the New Frontier ... in 2016, and is projected to grow at a compound annual ... by 2025. The medical cannabis market is projected to grow at ... to an estimated $13.3 billion in 2025. These projections do not ...
(Date:3/22/2017)... -- TFS is pleased to announce the appointment of ... two global executive positions in Medical Affairs and Clinical Development. Dr. ... and will report to Dr. Montse BarcelĂł , Chief Operating ... ... of medical and scientific expertise gained across leading biopharmaceutical companies and ...
Breaking Medicine Technology: