Navigation Links
A potential new target for treatment of hormone refractory prostate cancer
Date:4/6/2009

A new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to regulate target genes linked with the progression of prostate cancer. The research, published by Cell Press in the April 7th issue of the journal Cancer Cell, may also drive creation of new strategies for the treatment of advanced prostate cancer that no longer responds to traditional anti-hormone therapies.

The AR is an important mediator for the development and progression of prostate cancer, including the progression to the aggressive and often lethal androgen-independent form of the disease. "Androgen ablation therapy is the most common treatment for advanced prostate cancer," offers senior study author, Dr. Yun Qiu from the University of Maryland School of Medicine. "However, many patients inevitably develop deadly recurrent cancers, which no longer respond to androgen blockade and are resistant to current therapy."

To better understand mechanisms associated with advanced prostate cancer, Dr. Qiu and colleagues performed a screen designed to search for proteins that interact with the AR in hormone-refractory prostate cancer cells. The researchers identified RNF6 as an AR associated protein and demonstrated that RNF6 induced ubiquitination of the AR and promoted AR transcriptional activity. Ubiquitination is a common protein modification that mediates a diverse range of cellular activities. One of the best known functions of ubiquitination is to promote protein degradation. However, ubiquitination of AR by RNF6 appeared to have a stabilizing effect on AR protein.

Importantly, inhibition of RNF6 or interference with ubiquitination of AR altered expression of a specific group of AR target genes and abrogated recruitment of AR and its required coactivators to androgen-responsive regulatory regions in these genes. The researchers went on to show that expression of RNF6 was increased in human prostate cancer tissues that do
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. UCLA study identifies designer estrogen as potential MS drug
3. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
4. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
5. Potential new approach to treat cognitive impairments in schizophrenia
6. Nosespray vaccine using aloe vera has exciting potential, researcher says
7. Network approach identifies potential breast cancer susceptibility gene
8. Liver fibrosis will be treated by a potential target
9. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
10. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
11. China Holdings, Inc. Announces 2nd Biomass Renewable Energy Project (Power Capacity: 50 MW); Total Potential: 100 MW in Biomass Energy Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... divide unless there is enough oxygen present to support ... types circumvent this rule. Researchers at The Johns Hopkins ... cells, warning signals, enabling cancers to continue to divide ... the researchers found that lysosomes the cell,s protein ... also uncovered new evidence that certain drugs can halt ...
(Date:7/28/2014)... Parker Waichman LLP, a personal injury law firm ... heroes of 9/11 are never forgotten, comments that the September ... According to a VCF message dated July 3, ... or before October 12, 2012 must file a Registration Form ... who were allegedly injured by the toxic dust cloud that ...
(Date:7/28/2014)... York, NY (PRWEB) July 28, 2014 ... literacy organization that has donated more than 200,000 books ... in 2001, announces the launch of Brooke’s Cooks, a ... values, while encouraging healthy living among at-risk children and ... Cooks will include a series of nutrition information workshops, ...
(Date:7/28/2014)... Utah (PRWEB) July 28, 2014 Bariatric ... and drinks, announced that it will be introducing three ... of products this summer. The additional flavors include: , ... pure taste-free protein , Inspire Pomegranate Razz Berry -­ ... flavor of soft-serve vanilla cone , Bariatric Eating's ...
(Date:7/28/2014)... one of two dopamine-producing regions in the brain was ... isoflurane or propofol. In the August issue of ... report that rats anesthetized with continuous doses of either ... up in response to electrical stimulation delivered to the ... major dopamine-releasing area, the substantia nigra, did not induce ...
Breaking Medicine News(10 mins):Health News:Cell's recycling center implicated in division decisions 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2
... By Steven Reinberg HealthDay Reporter , ... have prostate cancer that,s considered "intermediate risk," radiation plus ... a new study finds. This combination of treatments, ... prostate cancer or advanced disease, the researchers said. Men ...
... cardiologists are prone to misinterpreting electrocardiograms when using ... heart defects that could make exercising perilous, according ... School of Medicine and Lucile Packard Children,s Hospital. ... acumen of pediatric cardiologists from several health-care institutions ...
... HealthDay Reporter , WEDNESDAY, July 13 (HealthDay News) -- ... infection can significantly reduce the chance they will develop the ... is an extremely exciting finding for the field of HIV ... a University of Washington associate professor of global health. ...
... , WEDNESDAY, July 13 (HealthDay News) -- Rural workers are often ... loved one and their jobs, researchers report. According to ... University of New Hampshire, people who work in rural communities have ... lost pay or lost jobs and caring for themselves or a ...
... control, growing wildly and breaking all the rules of orderly ... is a balance between a cancer cell,s revved-up metabolism and ... depends on a hyperactive metabolism to fuel its rapid growth, ... reactive oxygen species (ROS) generated by such high metabolic demand. ...
... WEDNESDAY, July 13 (HealthDay News) -- Wearing flip-flops and baseball ... warns. "Most skin cancers occur on the parts of ... Rebecca Tung, director of the dermatology division at Loyola University ... release. "The problem with flip-flops and baseball caps is ...
Cached Medicine News:Health News:For Some Prostate Cancer Patients, Combo Treatment Improves Survival 2Health News:For Some Prostate Cancer Patients, Combo Treatment Improves Survival 3Health News:Pediatric cardiologists not always accurate in interpreting ECG results for young athletes 2Health News:Pediatric cardiologists not always accurate in interpreting ECG results for young athletes 3Health News:Drugs May Prevent HIV Spread Among Heterosexuals 2Health News:Drugs May Prevent HIV Spread Among Heterosexuals 3Health News:Rural Workers Often Lack Access to Sick Leave 2Health News:Taking out a cancer's co-dependency 2Health News:Taking out a cancer's co-dependency 3Health News:Flip-Flops, Baseball Caps May Raise Risk of Skin Cancer 2
(Date:7/28/2014)... July 28, 2014 Concord Medical Services Holdings ... CCM ), a leading specialty hospital management solution provider ... diagnostic imaging centers in China , ... of Directors declared a special cash dividend of US$0.30 ... ("ADS")) on the Company,s outstanding ordinary shares. The total ...
(Date:7/28/2014)... July 28, 2014 ... 2,5 Millionen £ investiert hat, um die ... Gesundheits-, Pharma- und Logistikbranche zu erfüllen. Albion ...      (Photo: http://photos.prnewswire.com/prnh/20140728/697982 ) ... OmPrompt sein beschleunigtes Wachstum mit Investitionen in ...
(Date:7/28/2014)... NEW PROVIDENCE, N.J. , July 28, 2014 /PRNewswire/ ... meet with Linde,s Healthcare division experts at the ... at McCormick Place in Chicago, Illinois ... nothing less than complete confidence in a reliable medical ... Segment manager. "Linde understands the importance of this critical ...
Breaking Medicine Technology:Concord Medical Declares Special Dividend 2OmPrompt erhält Finanzierung für Marktexpansion von Kundenautomatisierungsmanagement 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
... Ill. and LONDON, Sept. 23 Following today’s announcements ... the European Medicines Agency (EMA) for rosiglitazone in the ... Takeda Pharmaceuticals Europe Limited (“Takeda”) underscore the company’s commitment ... and to the millions of people living with type ...
... Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two ... of 1,800 Real-World Patients Compared XIENCE V to the Newer-Generation TAXUS® Liberte®,-- ... Performance in Key Safety and Efficacy... -- ABBOTT PARK, Ill., Sept. 23 ... ...
Cached Medicine Technology:Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 2Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 3Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 4Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 2Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 3Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 4Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 5Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 6Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 7Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 8Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 9
Transcranial vascular DWL doppler....
Transcranil vascular DWL doppler....
... is a powerful automated system capable of ... from 6 user-programmable test protocols to begin ... Any tests not included in the comprehensive ... handled using the Doppler, PVR and PPG ...
The CD Horizon M10 Spinal System provide spine surgeons comprehensive solutions for the treatment of spinal deformities, trauma reconstruction, and degenerative conditions....
Medicine Products: