Navigation Links
A potential molecular target for biotherapy esophageal squamous cell carcinomas
Date:2/19/2009

The cadherin superfamily has a correlate relationship with the invasion and metastasis of carcinoma. It has been suggested that, unlike E-cadherin, N-cadherin may promote motility and invasion in carcinoma cells. To explore clinical pathological significance of E-cadherin and N-cadherin expressions in esophageal squamous cell carcinoma (ESCC), a research team led by Prof. Qing-Xia Fan from China detected the expression of E-cadherin and N-cadherin in 62 cases of normal esophageal epithelium, 31 cases of adjacent atypical hyperplasia epithelium and 62 cases of esophageal squamous cell carcinoma.Their study will be published on February 14, 2009 in the World Journal of Gastroenterology.

They found that the positive rates of N-cadherin decreased in the carcinoma, adjacent atypical hyperplastic and normal esophageal tissues (75.8%, 61.3% and 29.0%, P < 0.05), respectively, while those of E-cadherin increased (40.3%, 71.0% and 95.2%, P < 0.05). The increased expression of N-cadherin and decreased expression of E-cadherin were related to invasion, differentiation, and lymph node metastasis (P < 0.05). The expression level of N-cadherin decreased in the N-cadherin knocked down cells, and the invasiveness of those cells decreased significantly as well. The number of cells which crossed the basement membrane filter decreased from 123.40 8.23 to 49.60 6.80 (P < 0.05).

The results indicated that E-cadherin and N-cadherin expression is correlated with the invasion and aggravation of ESCC. The down-regulation of N-cadherin lowers the invasiveness of EC9706 cell line


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists uncover secrets of potential bioterror virus
2. HotHead Technologies Heat Sensor Shows Exciting Potential by Kennesaw State University Researchers
3. Potential atherosclerosis drug exhibits no harmful side-effects in liver
4. DOR BioPharma Announces Potential $30 Million North American Partnership Agreement with Sigma-Tau Pharmaceuticals for orBec(R) in the Treatment of Graft-versus-Host Disease
5. Brain Protein May Have Potential Against Alzheimers
6. BurrellesLuce IT Expert to Explore Web 3.0's Potential PR Impact At February Luncheon Meeting of Westchester/Fairfield PRSA
7. MDS Analytical Technologies Laser Capture Microdissection Helps Facilitate Discovery of Potential New Colon-Cancer Biomarker
8. Hard To Treat Diseases (HTDS) Announces Initial Research Results on Potential MS Therapy
9. Study identifies potential safe period for hormone replacement use
10. Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption
11. Maximum Potential Offers Affordable Training Course for Parents of Children with Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... 2017 , ... The Patient Advocacy Community of The Beryl Institute presented Eve ... Ravich Patient Advocacy Award in recognition of her extraordinary contributions to the field ... at The Beryl Institute’s annual Patient Experience Conference on March 20 in ...
(Date:4/21/2017)... Sterling, VA (PRWEB) , ... April 21, 2017 ... ... hosting its first weeklong campaign, AWARE: A Week of Addiction and Recovery Education, ... emerging evidence in treating and preventing substance use disorders. , The mission ...
(Date:4/21/2017)... Malvern, Worcestershire, UK (PRWEB) , ... April 21, ... ... Queen’s Award for Enterprise in the category of International Trade, the UK’s most ... performance in international trade, which represents 95% of total revenues and has grown ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Westside ... experienced, personalized dental care since 1985. After thirty-two years, Dr. Latner has become one ... to help my numerous clients over the years with all their dental needs,” said ...
(Date:4/21/2017)... ... 21, 2017 , ... Federal mandate, fines, controversy, questions about ... Obamacare program that most Republicans love to hate and Texas Agriculture Commissioner Sid ... , Like Obamacare, the Miller program centers upon a federal mandate. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, ... on providing the Urology, Uro/Gyn and Gynecology markets with ... the first quarter ended March 31, 2017 after the ... The Company will host a conference call and ... on Tuesday, May 2, 2017 at 4:30 p.m. Eastern ...
(Date:4/18/2017)...  Socionext Inc. and SOINN Inc. today announced ... which Socionext extracts and delivers biometrics data to ... results in reading ultrasound images from Socionext,s viewphii™ ... results will be introduced at Medtec Japan, held ... 4505 & 4507. In this initial ...
Breaking Medicine Technology: