Navigation Links
A potential molecular target for biotherapy esophageal squamous cell carcinomas
Date:2/19/2009

The cadherin superfamily has a correlate relationship with the invasion and metastasis of carcinoma. It has been suggested that, unlike E-cadherin, N-cadherin may promote motility and invasion in carcinoma cells. To explore clinical pathological significance of E-cadherin and N-cadherin expressions in esophageal squamous cell carcinoma (ESCC), a research team led by Prof. Qing-Xia Fan from China detected the expression of E-cadherin and N-cadherin in 62 cases of normal esophageal epithelium, 31 cases of adjacent atypical hyperplasia epithelium and 62 cases of esophageal squamous cell carcinoma.Their study will be published on February 14, 2009 in the World Journal of Gastroenterology.

They found that the positive rates of N-cadherin decreased in the carcinoma, adjacent atypical hyperplastic and normal esophageal tissues (75.8%, 61.3% and 29.0%, P < 0.05), respectively, while those of E-cadherin increased (40.3%, 71.0% and 95.2%, P < 0.05). The increased expression of N-cadherin and decreased expression of E-cadherin were related to invasion, differentiation, and lymph node metastasis (P < 0.05). The expression level of N-cadherin decreased in the N-cadherin knocked down cells, and the invasiveness of those cells decreased significantly as well. The number of cells which crossed the basement membrane filter decreased from 123.40 8.23 to 49.60 6.80 (P < 0.05).

The results indicated that E-cadherin and N-cadherin expression is correlated with the invasion and aggravation of ESCC. The down-regulation of N-cadherin lowers the invasiveness of EC9706 cell line


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. Scientists uncover secrets of potential bioterror virus
2. HotHead Technologies Heat Sensor Shows Exciting Potential by Kennesaw State University Researchers
3. Potential atherosclerosis drug exhibits no harmful side-effects in liver
4. DOR BioPharma Announces Potential $30 Million North American Partnership Agreement with Sigma-Tau Pharmaceuticals for orBec(R) in the Treatment of Graft-versus-Host Disease
5. Brain Protein May Have Potential Against Alzheimers
6. BurrellesLuce IT Expert to Explore Web 3.0's Potential PR Impact At February Luncheon Meeting of Westchester/Fairfield PRSA
7. MDS Analytical Technologies Laser Capture Microdissection Helps Facilitate Discovery of Potential New Colon-Cancer Biomarker
8. Hard To Treat Diseases (HTDS) Announces Initial Research Results on Potential MS Therapy
9. Study identifies potential safe period for hormone replacement use
10. Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption
11. Maximum Potential Offers Affordable Training Course for Parents of Children with Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Science published an article about bexarotene as ... important starting point for further Alzheimer,s research. The research ... VIB and KU Leuven in collaboration with the ... scientists at Janssen Pharmaceutica, Beerse, also tested this candidate ... were different, as were those of two American study ...
(Date:5/23/2013)... while being dragged to its destruction inside a ... sending signals that thwart the development of tumor-suppressing ... an early online publication at Nature . ... by tumors, the epidermal growth factor receptor (EGFR) ... team led by scientists at The University of ...
(Date:5/23/2013)... May 23, 2013 The Rottenstein Law ... firm, has created the Tylenol Lawsuit Information Center at ... Tylenol users and those who are considering filing lawsuits. ... to potentially cause severe liver damage, according to a ... In the “safety communication,” the FDA warned consumers ...
(Date:5/23/2013)... Washington, DC (PRWEB) May 23, 2013 ... have a great deal of control over their level ... their weight, yet far fewer are actually taking that ... International Food Information Council (IFIC) Foundation’s 2013 Food & ... of respondents say it’s possible to have “a great ...
(Date:5/23/2013)... IL (PRWEB) May 23, 2013 Jeanne ... fifth anniversary of its popular and only free OCD ... a successful continuing resource for OCD sufferers, the group ... OCD, and related disorders. This allows group participants ... and Exposure and Response Prevention. , “Participants in Beyond ...
Breaking Medicine News(10 mins):Health News:New insights contradict promising Alzheimer's research 2Health News:When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs 2Health News:When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs 3Health News:Rottenstein Law Group LLP Now Accepting Tylenol Cases, Announces New Tylenol Lawsuit Information Center 2Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 2Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 3Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 4Health News:Beyond OCD Support Group Marks Fifth Anniversary 2
... WASHINGTON Say nanotechnology, and geeks imagine iPhones, laptops ... of the 580 products in a newly updated ... items as tennis racquets, clothing, and health products. ... Nanotechnologies at www.nanotechproject.org/consumerproducts, the updated inventory includes Head ...
... Oct. 2 On Saturday, September 29, over 850,people ... of the most,grueling workouts ever devised, the Crossfit Fight ... Cure, an initiative of the Prostate Cancer,Foundation. Over 4,000 ... pledges and thanks to a matching funds grant from ...
... Ranbaxy One of Few Companies to Offer Both Suspension ... Ranbaxy Pharmaceuticals Inc.,(RPI), a wholly owned subsidiary of Ranbaxy ... approval from the U.S. Food and,Drug Administration (U.S. FDA) ... mg/5 mL and 250 mg/5 mL. Ranbaxy is the ...
... CYNACON/OCuSOFT (OCuSOFT,Inc.), a company specializing in ... optometrists, is pleased to announce the,appointment of ... Scientific,Advisory Board. *(LOGO: Send2Press.com/mediaboom/07-0803-Occusoft_72dpi.jpg) Dr. ... Eye Surgery in New York,City. She is ...
... producers,in the United States should be cautious but not ... director at Kansas,State University. Gary Anderson, director of ... the virus, which recently cropped up in the United,Kingdom, ... United States. "We are fortunate that bluetongue virus ...
... SAN FRANCISCO, Oct. 2 The American Dental,Association ... the,disposal of dental amalgam waste to include the ... plumbing to capture and,remove at least 95 percent ... system. The use of separators will allow greater ...
Cached Medicine News:Health News:Nanotechnology: not just for geeks 2Health News:Crossfit Workout Challenge Raises Over $500,000 in Four Hours for Athletes for a Cure 2Health News:Ranbaxy First to Gain Approval to Manufacture and Market Clarithromycin for Oral Suspension, USP 2Health News:K-State Veterinary Lab Routinely Tests For Bluetongue Virus; Lab Director Says Strains Found in Kansas, U.S. Usually Less-Virulent 2Health News:ADA Updates Environmental Recommendations for Handling Waste 2
(Date:5/23/2013)... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Executive Officer of Neurocrine Biosciences, will be presenting at the ... in Boston.   The live presentation takes place ... 8:20 a.m. Pacific Time.  The presentation will be webcast and ... . If you are unable to attend ...
(Date:5/23/2013)... Hearing health affects a man,s lifestyle, and if ... and professionally engaged, he should address any hearing loss he ... Better Hearing Institute (BHI) is delivering to men ... Week , which leads up to and includes Father,s Day. ... through June 16. To help men address ...
(Date:5/23/2013)... 2013  Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: ... based on intellectual property developed and owned by ... foremost medical research center, today announced that its ... funding from the Israeli Ministry of Industry and ... support product development and advance clinical trials. Cell ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2
... Switzerland, September 16 Mymetics,Corporation (OTCBB: MYMX), ... their preliminary SHIV challenge results on non-human ... vaccine designed,for triggering mucosal protection. The results ... 70% effectiveness to be considered as a,promising ...
... of non-inferiority to a rapid-acting ... ... MNKD ) today released preliminary top-line results from,a Phase 3 clinical ... (Study 009). This study compared the safety and,efficacy of prandial inhalations ...
Cached Medicine Technology:Successful Results for Mymetics Corporation's Mucosal HIV/AIDS Vaccine Viral Challenge Significantly Exceeds Expectations 2Successful Results for Mymetics Corporation's Mucosal HIV/AIDS Vaccine Viral Challenge Significantly Exceeds Expectations 3Successful Results for Mymetics Corporation's Mucosal HIV/AIDS Vaccine Viral Challenge Significantly Exceeds Expectations 4MannKind Reports Positive Data from a Phase 3 Clinical Study of Technosphere Insulin in Type 1 Diabetes 2MannKind Reports Positive Data from a Phase 3 Clinical Study of Technosphere Insulin in Type 1 Diabetes 3MannKind Reports Positive Data from a Phase 3 Clinical Study of Technosphere Insulin in Type 1 Diabetes 4MannKind Reports Positive Data from a Phase 3 Clinical Study of Technosphere Insulin in Type 1 Diabetes 5
... any arm -- simply bend the aluminum forearm ... The cuffs are connected by an aluminum bar ... elbow angle. The central part of the joiner ... elbow joint.,Special attention is paid to the patient ...
... lightweight ankle splint may be used for ... ankle. It is effective in stabilizing ... or after cast removal. The rigid ... excellent side-to-side support. The stays also ...
... is designed to assist ambulation for those ... resulting in drop-foot. The anatomically correct shape ... is fabricated from specially formed orthopedic grade ... and reliability. For a more comfortable individual ...
... The VacoSplint has a rigid shell with ... an immobilized foot/ankle. The VacoSplint is a non-weight ... weight bear he/she should transfer to the STORM ... remove the nylon liner from the STORM and ...
Medicine Products: