Navigation Links
A potential drug for liver carcinoma
Date:5/22/2009

Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, anti-virus, antidiabetogenic activity and clear anxiolytic effect. However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its derivatives have been prepared for biological testing. 5-allyl-7-gen-difluoromethylenechrysin (ADFMChR) is one of them.

A research team led by Dr. Jian-Guo Cao from China investigate the anti-tumor effect of ADFMChR in vitro. Their study will be published on May 14, 2009 in the World Journal of Gastroenterology.

In their study, HepG2 cells and L-02 cells were cultured and the inhibitory effect of ADFMChR on their proliferation was measured by MTT assay. The apoptosis of HepG2 cells was determined by flow cytometry using propidium iodide fluorescence staining. The influence of ADFMChR on the proxisome proliferator-activated receptor γ (PPARγ), NF-κB, Bcl-2 and Bax protein expression of HepG2 cells were analyzed by Western blotting.

They found that ADFMChR significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner, with little effect on growth of L-02 cells. Western blotting analysis revealed that after 24 h of treatment with 3.0, 10.0, 30.0 μmol/L ADFMChR, PPARγ and Bax protein expression increased but Bcl-2 and NF-κB expression decreased in HepG2 cells; however, pre-incubation with 10.0 μmol/L GW9662, a blocker of PPARγ, could efficiently antagonize and weaken the regulatory effect of 3.0, 30.0 μmol/L ADFMChR on PPARγ and NF-κB protein expression in HepG2 cells.

This finding may provide a molecular basis for the clinically observed cancer-preventive effects o
'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System
2. GlaxoSmithKline Travel Health: 55 percent of travellers needlessly put themselves at risk from a potentially fatal virus
3. Sodium channel blocker shows promise as a potential treatment for cystic fibrosis
4. Study Supports Swine Flus Pandemic Potential
5. Swine flu: Early findings about pandemic potential reported in new study
6. Mach One Corporation Announces Hand Carried Product as a Potential Solution to Swine Flu (H1N1) Virus
7. Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession
8. New Paint Shows Germ-Fighting Potential
9. New technique may help detect potential breast cancer spread
10. A potential anti-ulcer herb medicine: Rocket Eruca sativa
11. Cardium Reports on New Excellarate(TM) Product Formulations to Expand Commercialization Potential Into Multiple Wound Healing Applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... ... extend and improve the lives of patients, according to a newly published report. ... to read the full article. , The authors of the new paper ...
(Date:8/29/2015)... Viejo, CA (PRWEB) , ... August 29, 2015 , ... ... Pro X . Each preset contains 15 seconds of unique footage that users can ... that rise, fall, zoom, attract and more. Users can customize color, brightness, scale, speed, ...
(Date:8/29/2015)... TX (PRWEB) , ... August 29, 2015 , ... ... allows the company to freely market and sell Arterosil and Arterosil HP, and ... Health Sciences, LLC (DHS) sued Vascular Health Sciences, LLC (VHS) in the United ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 United Methodists ... celebrate children helping children, a thank you to the many creative and generous ... to the United Methodist initiative to end malaria deaths. , The Columbus Zoo ...
(Date:8/28/2015)... ... August 28, 2015 , ... For Dallas, the time ... part with their subsidiary USPI Tenet Health. , The American Heart Association hosts their ... and stroke. They believe that together, a difference can be made. Walkers can participate ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2
... &,Johnson will participate in the 28th Annual Cowen ... at the Boston Marriott Copley Place,Hotel in Boston, ... the Company in a session scheduled at 11:00,a.m. ... to investors and other interested parties,by accessing the ...
... of evidence suggests the medications speed tumor growth, shorten ... a U.S. Food and Drug Administration advisory panel meets ... use in cancer patients suffering from anemia, the question ... , According to FDA briefing documents filed this week, ...
... 800% heading into spring, PORT WASHINGTON, N.Y., March ... falling apart. Due to unemployment, foreclosures and gas at,an ... their wallets.,People are becoming more and more apprehensive about ... programs. Consumers are,having a tough time trying to justify ...
... Big at Arnold Classic; Says ... -, PHOENIX, March 13 NutraCea (OTC Bulletin,Board: ... nutrient,research and technology announced today that champion powerlifter Mike,Bridges, ... with a squat lift of 716 pounds in the ...
... for ... remote workforce, ... health insurance organization, sought a trusted,method to enable secure enterprise ... Universa selected Entrust,Inc. (Nasdaq: ENTU ) and the Entrust ...
... eScriptMessenger Eases Compliance with Upcoming Federal Mandates, ... the leading provider,of next generation healthcare connectivity ... has selected Kryptiq,s eScriptMessenger(TM),(eSM) as its enterprise ... to date, will enable BMC prescribers to ...
Cached Medicine News:Health News:FDA Panel Weighs Safety of Anemia Drugs for Cancer Patients 2Health News:FDA Panel Weighs Safety of Anemia Drugs for Cancer Patients 3Health News:Lose Weight This Spring With Portion Control Diet Tool 2Health News:New World Record Holder in Powerlifting Credits NutraCea's Unique Rice-Bran-derived Product as his 'Secret Weapon' 2Health News:New World Record Holder in Powerlifting Credits NutraCea's Unique Rice-Bran-derived Product as his 'Secret Weapon' 3Health News:New World Record Holder in Powerlifting Credits NutraCea's Unique Rice-Bran-derived Product as his 'Secret Weapon' 4Health News:Enabling the Mobile Workforce ... Entrust Deploys Strong Authentication for German Health Insurance Expert 2Health News:Enabling the Mobile Workforce ... Entrust Deploys Strong Authentication for German Health Insurance Expert 3Health News:Boston Medical Center Meets Prescription Challenges With Kryptiq ePrescribing Solution 2Health News:Boston Medical Center Meets Prescription Challenges With Kryptiq ePrescribing Solution 3
(Date:8/30/2015)... August 30, 2015 La ... l cuidado al paciente ...   Royal Philips  (NYSE: PHG, ... IntelliSpace Cardiovascular , un sistema web de gestión ... acceder, analizar y compartir imágenes cardiovasculares e información en ...
(Date:8/29/2015)... y LONDRES, August 29, 2015 ... Inteligencia Anatómica para los sistemas de imagen ... reproducibles en Ecografía, tiempos de examen rápidos y un ... en mayor confianza diagnóstica en el proceso de detección ... PHG, AEX: PHIA) ha anunciado hoy el lanzamiento europeo ...
(Date:8/28/2015)... -- With the heroin epidemic in the United ... -based Lakeview Health drug and alcohol treatment center,s ... why fentanyl is causing a new wave of overdoses. ... potent than pharmaceutical grade heroin and often illegally purchased ... death skyrockets. "Fentanyl can be an important ...
Breaking Medicine Technology:Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5Lakeview Health's Dr. Philip Hemphill Explains Why Heroin Addicts Are Now Dying of Fentanyl Overdoses 2
... DIEGO, Nov. 24 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ... Annual Piper Jaffray Healthcare Conference on Tuesday, December 1, 2009 ... is being held at The New York Palace Hotel. ... will provide an overview of Anadys and its clinical development ...
... , POTOMAC, Md., Nov. 24 In ... has added Philadelphia jurors to her Thanksgiving gratitude list. ... I am so thankful to them," she said of Monday,s ... , Wisneski is among 12,000 women nationwide who have sued ...
Cached Medicine Technology:Anadys Pharmaceuticals to Present at the Piper Jaffray Healthcare Conference 2Maryland Woman Thankful for Wyeth Verdicts 2
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
The Novus 2000 argon laser combines power, size, and versatility. Ideal for the office, clinic and operating room environments, Novus 2000 is the world's most widely accepted ophthalmic laser....
Practice-oriented ophthalmic laser systems for photodisruption....
... determining color vision abnormalities and testing color ... applied to many psychological and industrial color ... trays containing a total of 85 removable ... variation on one side and are numbered ...
Medicine Products: