Navigation Links
A potential drug for liver carcinoma
Date:5/22/2009

Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, anti-virus, antidiabetogenic activity and clear anxiolytic effect. However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its derivatives have been prepared for biological testing. 5-allyl-7-gen-difluoromethylenechrysin (ADFMChR) is one of them.

A research team led by Dr. Jian-Guo Cao from China investigate the anti-tumor effect of ADFMChR in vitro. Their study will be published on May 14, 2009 in the World Journal of Gastroenterology.

In their study, HepG2 cells and L-02 cells were cultured and the inhibitory effect of ADFMChR on their proliferation was measured by MTT assay. The apoptosis of HepG2 cells was determined by flow cytometry using propidium iodide fluorescence staining. The influence of ADFMChR on the proxisome proliferator-activated receptor γ (PPARγ), NF-κB, Bcl-2 and Bax protein expression of HepG2 cells were analyzed by Western blotting.

They found that ADFMChR significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner, with little effect on growth of L-02 cells. Western blotting analysis revealed that after 24 h of treatment with 3.0, 10.0, 30.0 μmol/L ADFMChR, PPARγ and Bax protein expression increased but Bcl-2 and NF-κB expression decreased in HepG2 cells; however, pre-incubation with 10.0 μmol/L GW9662, a blocker of PPARγ, could efficiently antagonize and weaken the regulatory effect of 3.0, 30.0 μmol/L ADFMChR on PPARγ and NF-κB protein expression in HepG2 cells.

This finding may provide a molecular basis for the clinically observed cancer-preventive effects o
'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System
2. GlaxoSmithKline Travel Health: 55 percent of travellers needlessly put themselves at risk from a potentially fatal virus
3. Sodium channel blocker shows promise as a potential treatment for cystic fibrosis
4. Study Supports Swine Flus Pandemic Potential
5. Swine flu: Early findings about pandemic potential reported in new study
6. Mach One Corporation Announces Hand Carried Product as a Potential Solution to Swine Flu (H1N1) Virus
7. Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession
8. New Paint Shows Germ-Fighting Potential
9. New technique may help detect potential breast cancer spread
10. A potential anti-ulcer herb medicine: Rocket Eruca sativa
11. Cardium Reports on New Excellarate(TM) Product Formulations to Expand Commercialization Potential Into Multiple Wound Healing Applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... folic acid could improve the memory and brainpower of ... the University of Wageningen gave a group of 818 ... or a dummy drug for three years, said the ... acid group had significantly better memories and were faster ...
... facial transplantation—including the psychological and ethical aspects// of the ... Surgeons of England now endorses moving cautiously forward in ... in the Jan. 27 issue of Transplantation. ... concluded that facial transplantation should not be attempted until ...
... A diabetes detection programme has been planned in Edmonton’s Capital ... of a person is recorded whenever he or she visits ... in a central database. This information can further be used ... ,If diabetes is not treated, it could manifest itself ...
... College of Wisconsin at Madison has been granted a whopping ... agents of bio terrorism// like the H5N1 virus. This was ... ,It has been said that the Avian influenza ... pandemic. There is also a constant threat from the terrorists ...
... Chennai: Vasan Eye Care Hospitals, one of the largest eye ... first branch here, with seven more in the offing. ... with K. Premraj, a prominent ophthalmic surgeon and managing director ... specialists. ,The Vasan Eye Care Group has ...
... recent study has concluded that low birthweight babies born with ... large quantities of dietary sodium later in their life. ... the most severe cases of low sodium blood serum consumed ... percent more than their peers. These data, taken together with ...
Cached Medicine News:Health News:Royal College Issues Revised Guidelines for Face Transplantation 2Health News:Royal College Issues Revised Guidelines for Face Transplantation 3Health News:Low Blood Sodium When Born Linked to Long Term Sodium Intake 2Health News:Low Blood Sodium When Born Linked to Long Term Sodium Intake 3
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, 2014 /PRNewswire/ ... Integrated Clinical Trial Services, LLC (ICTS), two firms ... trials announce that they have formed a joint ... i-CTMS will provide a broad range of patient ... medical device companies. i-CTMS will be ...
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/bf3b6l/electrocardiogram ) has ... - Global Trends, Estimates and Forecasts, 2012-2018" report ... Global Electrocardiogram Devices (ECG) sector is ... North America accounts for nearly 36% ... Europe claims approximately 27% (2018). ...
(Date:12/15/2014)... YORK and HERZLIYA PITUACH, Israel ... "Company") (NASDAQ: IMNP ) announced today that its ... the Board succeeding Dr. Daniel Teper who continues ... a member of Immune,s Board of Directors since 2013. ... "I am delighted to represent the interest of shareholders and ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... a dynamic, service-oriented healthcare technology company has announced an ... and Practice Management software products. This update will enable ... the requirements set forth by the Centers for Medicare ... (Logo: http://photos.prnewswire.com/prnh/20101115/NY01712LOGO ) Currently, SequelMed ...
... capital, a burdensome and uncertain regulatory environment and lack ... the biggest threats to the biomedical industry,s growth over ... surveyed by CHI-California Healthcare Institute, BayBio and PwC US. ... quarters (74 percent) of biomedical industry CEOs surveyed said ...
Cached Medicine Technology:SequelMed Announces ANSI 5010 Upgrade for Its Users 2Survey of Biomedical Industry CEOs Finds Lack of Investment and Regulatory Environment Threaten Future Growth and Innovation 2Survey of Biomedical Industry CEOs Finds Lack of Investment and Regulatory Environment Threaten Future Growth and Innovation 3Survey of Biomedical Industry CEOs Finds Lack of Investment and Regulatory Environment Threaten Future Growth and Innovation 4Survey of Biomedical Industry CEOs Finds Lack of Investment and Regulatory Environment Threaten Future Growth and Innovation 5
... up and safe to use, the Gel XL ... running agarose gels. The unit is compact, requiring ... power supply eliminates a tangled mess of leads ... Designed for safety and convenience, the power supply ...
... horizontal gel system is designed for very fast and ... This System allows the user to cast, run, and ... system with : 1 x electrophoresis tank and cover, ... x 83 mm tray), 2 x MT-T02 (50 x ...
... 33 Mini Submarine Unit for nucleic acid analysis in ... for very fast separations of DNA restriction fragments in ... heat-sink. Fill the base with coolant and seal. Precool ... the unit in a freezer or by immersing it ...
... Mini Submarine Unit for nucleic acid analysis in the ... very fast separations of DNA restriction fragments in agarose ... Fill the base with coolant and seal. Precool the ... unit in a freezer or by immersing it in ...
Medicine Products: