Navigation Links
A potential approach to treatment of hepatitis B virus infection
Date:9/9/2008

Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. There are two branches in the checkpoint response pathwayataxia telangiectasia-mutated (ATM) and ATM-Rad3-related (ATR). Many viruses are now known to interact with DNA damage sensing and repair machinery. These viruses have evolved tactics to eliminate, circumvent, or exploit various aspects of the DNA damage response of the host cell. Strategies include the activation of repair proteins or the targeting of specific cellular factors for degradation or mislocalization. Exploiting the activation of the DNA damage pathway by viral replication for the generation of antiviral drugs needs to be examined. In the human immunodeficiency virus (HIV), it has been clearly determined that the prevention of viral integration inhibits viral replication and promotes cellular apoptosis. Thus, the ATM-specific inhibitor ku55933 can inhibit HIV replication in primary T cells.

Despite the availability of a safe and efficient vaccine, chronic hepatitis B virus infection remains a major health problem worldwide. Interferon treatment is effective in only approximately one-third of the patients and produces considerable side effects. Long-term treatment with the second-generation nucleoside analogue lamivudine (lam) efficiently inhibits HBV replication with frequent viral polymerase mutations. We found that HBV infection triggered an ATR-dependent DNA damage response, resulting in increased ATR and Chk1 phosphorylation levels, however, ATR checkpoint signaling was blocked downstream of the p53-dependent pathway to evade apoptosis by p21 degradation. We have designed a strategy to select new drug targets that inhibit a cellular gene required for HBV replication or restore a response stalled by HBV in the ATR DNA damage pathway.

A research article to be published on August 28, 2008 in the World Journal of Gastroenterology addresses th
'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. LegalView Warns Proton Pump Inhibitor Patients of Potential Bone Fracture Risk Associated with Drug
2. Measures to assess potential lung injury during ventilation inadequate
3. Malaria prevention reduces anemia and improves educational potential in Kenyan schoolchildren
4. PMC and County Announce Potential Capital Partners for Hospital
5. Announcement Outlines 36 Month Custom Deployment Contract With Potential Revenues Reaching $30 Million Dollars
6. Wake Forest researchers say popular fish contains potentially dangerous fatty acid combination
7. Study further defines potential role of fish-based fatty acids in resolving, preventing asthma
8. CIBC World Markets Equity Research Downgrades Target Price of BVF from $12.00 to a Staggering Low of $7.50 Based on Potential Incumbent Win in Proxy Battle
9. Cytopia To Present Data on FMS Program With Anticancer Potential
10. Potential new role for red grape seeds in treatment of Alzheimers disease
11. Personalizing medicine: New research shows potential of targeted therapies for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... nearly 20 years, June Cotner has been the go-to ... life's rites of passage. Here, she joins forces with ... Toasts: The Perfect Words to Celebrate Every Occasion , ... and containing many original toasts written just for this ... contains sayings famous and profound, suitable and sentimental. Covering ...
(Date:12/24/2014)... December 24, 2014 “ Relax Melodies ... monthly AppWatch, which features the latest and coolest mobile ... Tropeano, a mobile technology expert and host of NewsWatch, ... this application soothes users so they can fall asleep. ... of adults say they have some sort of difficulty ...
(Date:12/24/2014)... As 2014 draws to a close, ... time and money into a new or tankless water ... in tankless and eco-friendly products or service. Greenstar urges ... in 2015 to research “green” and environmentally friendly options ... Services specializes in eco-friendly and environmentally conscious products ...
(Date:12/24/2014)... 24, 2014 Dr. Ronald Receveur, a ... experience placing dental implants in a day, ... effects of overusing teeth-whitening treatments. , In his ... , Dr. Receveur writes that overusing teeth-whitening treatments can ... damage to enamel. , “Because teeth-whitening treatments ...
(Date:12/24/2014)... Kathleen Doheny HealthDay Reporter ... steady diet of fast food might hurt your child in ... ate fast food in fifth grade lagged behind by eighth ... more than 8,500 U.S. students. "The largest effects were ... food," said study leader Kelly Purtell, assistant professor of human ...
Breaking Medicine News(10 mins):Health News:An Application to Help with Insomnia was Featured on NewsWatch Television on December 19, 2014 2Health News:Greenstar Home Services Offers Tankless Water Heater Advice to Local Homeowners 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 3Health News:Can Fast Food Hinder Learning in Kids? 2
... in French . Montreal, September 1, 2009 ... bacteria from the skin of the fruit, holds great promise ... the International Journal of Obesity , was conducted by ... the Universit de Moncton who tested the effects of biotransformed ...
... , , CHICAGO, Sept. 1 ... launched a new online video series, called " Living Positive By ... and AIDS education initiative. The Living Positive By Design ... to encourage thoughtful conversations about HIV and AIDS, to confront HIV ...
... , SEARCY, Ark., Sept. 1 Fourteen ... this year,s National Day of Encouragement with the first ever "7 ... The tour will launch September 5 in San Francisco and conclude ... and commemoration of the third annual National Day of Encouragement in ...
... , WASHINGTON, Sept. 1 The ... Tobacco-Free Kids: , , (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) ... Tobacco Company, Lorillard Inc. and other tobacco manufacturers that they have ... legislation is not unexpected. The lawsuit, filed in the federal court ...
... , CINCINNATI, Sept. 1 ... physician office-based patient-education programs has announced that SIGVARIS, the ... expanding to the Skin Care Network to broaden their ... office is an ideal place to increase the awareness ...
... MILFORD, Mass., Sept. 1 Waters Corporation (NYSE: ... Division of the American Chemical Society presented Prof. John R. ... Achievements by a Young Analytical Scientist. Through a ... the combined use of hydrogen-deuterium (H/D) exchange technology ...
Cached Medicine News:Health News:Biotransformed blueberry juice fights fat and diabetes 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 2Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 4Health News:RJR, Other Tobacco Companies Go to Court to Evade Regulation by FDA 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 3Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 2Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 3
(Date:12/24/2014)...   Assurex Health, a personalized medicine company ... for behavioral health and chronic pain conditions, today ... equity financing from new and existing investors, according ... Chief Executive Officer. The financing will ... Health,s GeneSight ®  products.  GeneSight,s patented ...
(Date:12/24/2014)... Dec. 23, 2014 Tianyin Pharmaceutical Co., ... specializes in patented biopharmaceutical, modernized traditional Chinese medicine ... today announced that the Company achieved the Public ... Practice (GMP) certificate of TPI,s Qionglai Facility (QLF) ... The public notice period is a significant procedure ...
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: