Navigation Links
A possible cause -- and cure -- for genital cancer in horses?

Horses are prone to develop genital cancer, especially as they grow older. Male horses are more commonly affected than mares but both sexes suffer from the condition, which is extremely difficult to treat and may result in the animals' death. Because of the similarity of the disease to human genital cancer it seemed possible that a similar agent might be responsible. Several human genital cancers, including cervical tumours, are known to be caused by a papillomavirus infection, so Brandt and her coworkers used genetic techniques to look for papillomavirus DNA in tissue samples from horses bearing genital squamous cell carcinomas (SCC).

Brandt freely concedes that the experiment has the feel of a "magic bullet", although the researchers did have good reasons to suspect the involvement of a virus. Nevertheless, it was extremely satisfying when their hunch proved correct and they succeeded in identifying a novel type of papillomavirus, which they have named Equus caballus papillomavirus-2 (EcPV-2). EcPV-2 DNA was found in all the genital SCC samples from affected horses in Austria and, independently, in nearly all the samples from such horses in the UK (a single exception may stem from experimental difficulties). The virus has not been detected in any samples from horses without tumours or with other types of cancer.

The scientists have succeeded in isolating and sequencing the entire genome of EcPV-2. Interestingly, the sequence shows that the novel virus is closely related to the two viruses known to be responsible for the majority of genital cancers in humans. This lends further weight to the idea that EcPV-2 might be involved in causing disease in horses.

Taken together, the results provide a strong indication that EcPV-2 causes genital cancer in horses. A final proof would require the demonstration that infecting mucous membranes with the virus eventually leads to the development of cancer and experiments of this kind have understandably not yet been performed. There is also a need for further studies to examine the frequency of the virus in horse populations. But the initial evidence already seems sufficiently cogent to justify attempts to prepare a vaccine. Perhaps the work of Brandt and her collaborators may soon lead to the development of preventative measures so that horses like humans no longer have to suffer from this debilitating and ultimately life-threatening disease.


Contact: Dr. Sabine Brandt
University of Veterinary Medicine -- Vienna

Related medicine news :

1. Gene information predicts survival time, possible new treatment options for lung-cancer patients
2. Autism breakthrough: Researchers identify possible treatment for impaired sociability
3. NIH study suggests that early detection is possible for prion diseases
4. Hong Kong hospital reports possible airborne influenza transmission
5. Possible Genetic Switches for Blood Sugar Control Detected
6. U of M researchers identify possible key to treating, understanding post-traumatic stress disorder
7. New Clues to Possible Genetic Basis for ADHD
8. OHSU research reveals possible method for boosting the immune system to protect infants against HIV
9. Parkinsons disease: Excess of special protein identified as key to symptoms and possible new target for treatment with widely used anti-cancer drug imatinib
10. Team of researchers finds possible new genetic risk for Alzheimers disease
11. 4 possible risk factors for ovarian cancer found
Post Your Comments:
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare International, Inc., the ... 61st annual Employee Benefits Conference. The Employee Benefits Conference was hosted by the ... Wednesday, November 11th, 2015. The conference was held at the Hawaii Convention Center ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... all, Water For Empowerment ™ attracts volunteers together who want to combine ... empowering women as key stakeholders in the process. The non-profit launched its first ...
(Date:11/25/2015)... ... ... Dr. John Pierce, Medical Director at the Ageless Forever clinic in Las ... Pro laser therapy cap. FDA cleared for safety and efficacy, the Capillus272 offers men ... surgery, prescription pills, or topical foams. , “Capillus272™ Pro is a home-use device ...
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, ... country to celebrate their sobriety and show through pictures what a positive difference ... photos this Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/25/2015)...  The American Academy of Pediatrics (AAP), American ... March of Dimes cheered today,s signature into law ... of 2015 (S.799), which takes much-needed strides ... to drugs, such as opioids, and to improve ... organizations have worked together leading advocacy efforts for ...
(Date:11/25/2015)... Nov. 25, 2015 On Tuesday, November ... bellwether trial against Wright Medical Technology, Inc. for ... Conserve metal-on-metal hip implant device, awarded $11 million ... two week trial and three days of deliberations, ... device was defectively designed and unreasonably dangerous, and ...
Breaking Medicine Technology: