Navigation Links
A pan-European study: Signs of motor disorders can appear years before disease manifestation
Date:5/22/2013

rom 2 to 24 years. These and all other test results remained anonymous: the data was not known to the test subjects, neither could the researchers assign it to specific participants. The same applied to individuals whose DNA turned out to be inconspicuous. "People in families with cases of ataxia usually have not taken a genetic test and they don't want to know any results. This kind of information has to be treated very carefully for ethical reasons," emphasizes Klockgether.

Extensive tests

The study participants made themselves available for various examinations including standardized tests of muscular coordination. These included measuring the time needed by the subjects to walk a specific distance. Another series of experiments involved inserting small pins into the holes of a board and taking them back out as quickly as possible. Yet another test measured how often the participants could repeat a certain sequence of syllables in ten seconds. "The tests were designed in such a way that they would provide significant information but still be easy to perform," says Klockgether. "Tests like these can be performed anywhere without need for special technology."

Technically complex methods were also used: all study participants were tested for the genetic defects relevant to ataxia. At some of the research centers involved in the study, it was also possible to examine the subjects with the aid of magnetic resonance imaging (MRI). This enabled researchers to measure the total brain volume as well as the dimensions of individual parts of the brain in about a third of the subjects.

Notable findings

In two of the four types of ataxia investigated, the scientists found signs of impending disease. "We found a loss in brain volume, particularly shrinkage in the area of the cerebellum and brain stem. These subjects also had subtle difficulties with coordination," Klockgether summarizes the results. "This means that ma
'/>"/>

Contact: Marcus Neitzert
marcus.neitzert@dzne.de
49-228-433-02271
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study: Older Whooping Cough Vaccine More Effective
2. Study: Peer-referral programs can increase HIV-testing in emergency departments
3. Study: Patient openness to research can depend on race and sex of study personnel
4. Study: Brain makes call on which ear is used for cell phone
5. Study: HIV Infection Does Not Adversely Affect Outcomes of Liver Transplantation for Hepatocellular Carcinoma
6. Penn pilot study: Group of Bradford Co, Pa. residents concerned about health effects of hydrofracking
7. Great HealthWorks, Inc., makers of Omega XL, Report New Independent Study: Omega-3 DHA Protects Against Liver Disease
8. New IU study: How often is more important than why when describing breakups
9. Study: Physicians less likely to bond with overweight patients
10. The doctor wont see you now? Study: US facing a neurologist shortage
11. Study: Dental bib clips can harbor oral and skin bacteria even after disinfection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... proliferation of endogenous neural precursor cells cannot alone ... From the perspective of neural plasticity, Dr. Yun ... China observed the effects of functional electrical stimulation ... expression of basic fibroblast growth factor and epidermal ... infarct side. The researchers found that functional electrical ...
(Date:4/22/2014)... the New Jersey Institute of Technology (NJIT) today ... the launch of the New Jersey Innovation Institute ... model for business innovation through the leveraging of ... U.S. Senator Cory Booker, Panasonic Corp. of North ... Lieutenant Governor Kim Guadagno, New Jersey Secretary of ...
(Date:4/22/2014)... primary care for low-income patients may ease the ... while improving patient health, researchers have concluded. , ... clinics that avoid costs associated with insurance administration ... admission rates and emergency room visits, according to ... , The researchers estimated that the major ...
(Date:4/22/2014)... risk of pregnancy among women using a newer method ... 10 times greater over a 10-year period than using ... researchers at Yale University and UC Davis has found. ... Contraception , the study found the higher risk ... the brand name Essure. , "This study provides ...
(Date:4/22/2014)... Johns Hopkins scientists have found a way to block ... development of atherosclerosis, the main cause of heart attacks ... humans. The condition develops when fat builds inside blood ... hardened, greatly reducing their ability to feed oxygen-rich blood ... a series of experiments, described April 7 in the ...
Breaking Medicine News(10 mins):Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Clinics not bogged down by red tape can ease health cost burdens 2Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4
... influenza testing is associated with reductions in the use ... ,The study was posted online today that ... of Archives of Internal Medicine, one of the JAMA/Archives ... speed at which influenza and other viral diseases are ...
... stress and depression,// may be associated with higher ... in turn are related to an increased risk for ... 22 issue of Archives of Internal Medicine, one of ... studies have linked psychosocial characteristics with cardiovascular disease and ...
... Union after a break of six months. Officials from Hungary ... holding of 3000 geese, and the death of 40 geese. The ... has been confirmed as the deadly H5N1 strain, samples are being ... measures are on to control the spread. A protection zone of ...
... Is the everyday talk of HIV/AIDS falling on deaf ears? ‘Careless’ ... today,// who appear to be completely in-charge of their lives, yet ... ,A new survey has shown that, nearly three out of ... getting HIV. , ,The Body Shop and MTV got ...
... history of abuse by intimate partners have significantly higher ... history of such abuse, according to a study conducted ... ,The higher costs and utilization continued long after the ... University of Washington (UW), and the Harborview Injury Prevention ...
... is how some passengers describe it.// , ... who were infected with a stomach flu-causing bug; norovirus aboard ... , This virus causes a contagious gastric illness, gastroenteritis that ... , The liner’s owner Cunard Line notified ...
Cached Medicine News:Health News:Rapid Flu Testing Decreases Antibiotic Use in Hospitalized Adults 2Health News:Psychosocial Factors Associated With Higher Levels of Inflammatory Markers 2Health News:Fowl Fall in Hungary-Bird Flu Strikes 2Health News:Health Care Costs - Significant for Abused Women 2
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
(Date:1/15/2014)... THOUSAND OAKS, Calif. , Jan. 15, 2014 ... and Amgen (NASDAQ: AMGN ) announced ... to jointly discover and validate new therapeutic targets ... (IBD), a chronic disorder that affects millions worldwide. ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Healthcare and,Laboratory Corporation of America(R) Holdings (LabCorp(R)) ... agreement to discuss future,possibilities to co-develop new ... diagnostics, metabolic syndrome, oncology and diabetes. Under ... new tests that,could make the biggest impact ...
... of the American Pain Society ... ... sustained pain relief from diabetic neuropathic pain (DNP),compared to placebo-treated patients, according ... (APS) in Tampa, Fla., "This is the first placebo-controlled trial of ...
Cached Medicine Technology:Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 2Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 3Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 4New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 2New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 3New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 4
Codman Hakim Programmable micro offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition will often change over the course of...
Codman Hakim Programmable valve cylindrical with PrechamberInline offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition wi...
... V is a low viscosity bone cement, ... vertebroplasty. The bone cement is injected into ... Osteopal V is used for the augmentation ... zirconium dioxide is included in the cement ...
Leadpoint Micro-Electrode Recording...
Medicine Products: