Navigation Links
A pan-European study: Signs of motor disorders can appear years before disease manifestation
Date:5/22/2013

The scientists report these findings in the current online edition of "The Lancet Neurology". This pan-European study could open up new possibilities of early diagnosis and smooth the way for treatments which tackle diseases before the patient's nervous system is irreparably damaged.

"Spinocerebellar ataxias" comprise a group of genetic diseases of the cerebellum and other parts of the brain. Persons affected only have limited control of their muscles. They also suffer from balance disorders and impaired speech. The symptoms originate from mutations in the patient's genetic make-up. These cause nerve cells to become damaged and to die off. Such genetic defects are comparatively rare: it is estimated that about 3,000 people in Germany are affected.

It is known that there are various subtypes of these neurodegenerative diseases. The age at which the symptoms manifest consequently fluctuates between about 30 and 50. "Our aim was to find out whether specific signs can be recognized before a disease becomes obvious," says project leader Prof. Thomas Klockgether, Director for Clinical Research at the DZNE and Director of the Clinic for Neurology at Bonn University Hospital.

Pan-European cooperation

The study, which involved 14 research centers in all, focused on the four most common forms of spinocerebellar ataxia. These account for more than half of all cases. More than 250 siblings and children of patients throughout Europe declared their willingness to participate in appropriate tests. These individuals had no obvious symptoms of ataxia. However, about half of them had inherited the genetic defects which invariably cause the disease to manifest in the long term.

With the aid of a mathematical model that considered the genetic mutations and their effects, the scientists were able to estimate the time remaining until the disease could be expected to manifest. In the test group, this "time to onset" varied f
'/>"/>

Contact: Marcus Neitzert
marcus.neitzert@dzne.de
49-228-433-02271
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study: Older Whooping Cough Vaccine More Effective
2. Study: Peer-referral programs can increase HIV-testing in emergency departments
3. Study: Patient openness to research can depend on race and sex of study personnel
4. Study: Brain makes call on which ear is used for cell phone
5. Study: HIV Infection Does Not Adversely Affect Outcomes of Liver Transplantation for Hepatocellular Carcinoma
6. Penn pilot study: Group of Bradford Co, Pa. residents concerned about health effects of hydrofracking
7. Great HealthWorks, Inc., makers of Omega XL, Report New Independent Study: Omega-3 DHA Protects Against Liver Disease
8. New IU study: How often is more important than why when describing breakups
9. Study: Physicians less likely to bond with overweight patients
10. The doctor wont see you now? Study: US facing a neurologist shortage
11. Study: Dental bib clips can harbor oral and skin bacteria even after disinfection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 The science of ... last decade. New and more efficient methods of FUE hair ... balding patients. One of the most cutting edge hair transplant ... Restoration is the technique of extracting hair from the beard ... are performed to correct male pattern baldness. Beard ...
(Date:5/29/2015)... 29, 2015 According to a recent HealthDay ... full-time workers has a substance abuse problem - the data, ... 111,500 adults with full-time jobs, revealed that 9.5% of those ... year. (1) The National Council on Alcoholism and Drug Dependence ... and an estimated 70% of the 14.8 million illicit drug ...
(Date:5/29/2015)... Cary, North Carolina (PRWEB) May 29, 2015 ... McCann confirmed that the newest Red Hot & Blue restaurant ... for business on Thursday, May 7, 2015. “The Red Hot ... shopping center for 18 years, but we have moved to ... “We are now in the middle of all the activities ...
(Date:5/29/2015)... To compile the list, the Becker's Hospital ... several awards for clinical and general excellence. The team ... to them in terms of overall excellence, and those ... 50 Great Health Systems to Know 2015 list includes ... Fla.) , Advocate Health Care (Downers Grove, Ill.) , ...
(Date:5/29/2015)... May 29, 2015 The Healthcare ... graduates of its Advanced Training Program (ATP) in ... fill roles in their health care organization ranging ... and methodology of continuous quality improvement in the ... to Dr. Brent James’ internationally recognized Advanced Training ...
Breaking Medicine News(10 mins):Health News:Beard to Scalp Hair Transplant: Newest Advance in Hair Transplant Technology 2Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 2Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 3Health News:Novus Medical Detox Comments on Government Study Findings: One in 10 American Workers Struggling with Substance Abuse 4Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 3Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 4Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:HORNE LLP’s Healthcare Delivery Institute Graduates Class from the Advanced Training Program 2
... certain factors that seem to increase risk, , , MONDAY, Jan. ... way to better calculate the risk a woman with cancer ... breast. , The chances of developing cancer in a second ... has been found in one breast. And certain factors, such ...
... boost protection from severe respiratory illnesses such as influenza and ... (UNSW) has found, but convincing a reluctant public and health ... trial of the efficacy of masks, researchers found adult mask ... non-wearers to be protected against respiratory viruses, including the common ...
... 26 Mr Yohei Sasakawa, WHO Goodwill Ambassador for ... for the Human Rights of People Affected by Leprosy, ... of the word "leper."Speaking at the launch in London ... Discrimination Against People Affected by Leprosy, held to coincide ...
... support the LIVESTRONG(TM) Global Cancer Summit to take place ... Lance Armstrong Foundation (LAF), a leading nonprofit organization providing ... today that it has selected Ogilvy Public Relations Worldwide ... fight against cancer. Ogilvy PR will work with ...
... Authentidate Holding Corp. (Nasdaq: ADAT ), ... and workflow management services, announced today that it ... and Parascript Management, Inc. (collectively "Parascript") that Parascript ... it entered into with Authentidate. The merger agreement, ...
... Doctors at the,Northwoods Cancer Center near Houston, Texas ... technology from Varian Medical Systems,(NYSE: VAR ... prostate cancer, is,among the first patients in Houston ... which delivers image-guided intensity-modulated radiation therapy,(IMRT) two to ...
Cached Medicine News:Health News:Unmasked and vulnerable 2Health News:Stop Use of Word 'Leper' 2Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 2Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 3Health News:Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign 4Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 2Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 3Health News:A Fast, New Cancer Fighting Tool Is Now Available in the Houston Area: RapidArc(TM) Radiotherapy Technology from Varian Medical Systems 2Health News:A Fast, New Cancer Fighting Tool Is Now Available in the Houston Area: RapidArc(TM) Radiotherapy Technology from Varian Medical Systems 3
(Date:5/29/2015)... , May 28, 2015 Research and Markets ... "North America MRI Market - Growth, Trends And ... The North American MRI systems market is ... 2014 to $1.58 billion by 2020 with a CAGR ... of three types namely, the open system, closed system ...
(Date:5/29/2015)... 2015 A six-hour certification program on "How ... the Cannabis World Congress & Business Exposition (CWCBExpo) ... .  Taking place on Wednesday, June 17 th ... at the leading event on the East Coast for the ... Clover Leaf University, the first cannabis university to be approved, ...
(Date:5/29/2015)... , May 28, 2015 Research and Markets ... "North America Open System MRI Market - Growth, ... their offering. The key players in the ... Healthcare, Siemens Healthcare and Toshiba Medical Systems ... is replacing CT because of its higher sensitivity and ...
Breaking Medicine Technology:North America MRI Market - Growth, Trends And Forecasts 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4North America Open System MRI Market 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare and Toshiba Medical Dominating 2
... Tunnell Consulting, Inc. announced today that ... Informatics, an integrated services and technology company based in ... sciences industry consultancy, and Campbell, a provider of data-driven ... is designed to enable both companies to serve their ...
... Biolabs (NEB) has announced that it has received ... fund the research and development of novel enzymatic ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b) New England ... epigenetics research and discovery, and offers a growing ...
Cached Medicine Technology:Tunnell Consulting Forms Strategic Alliance With Ireland-Based Campbell Informatics 2New England Biolabs Receives Award to Develop Novel Enzymatic Reagents for Epigenetic Studies 2
... self-adjusting adaptability to fit almost every operating ... angling at the sit of fixation to ... it to be titled to any position ... a simple adjustment of the 3/D Swinger ...
Inquire...
Stainless steel construction to withstand sterilization modalities (EtO, Steris, and Sterrad)...
Stainless steel construction to withstand sterilization modalities (EtO, Steris, and Sterrad) Wide angle of view...
Medicine Products: