Navigation Links
A novel computational model -- how Parkinson's medications affect learning and attention
Date:1/20/2010

Newark, NJ A new brain-based computational model is helping to understand how Parkinson's disease and dopamine medicationsused to treat motor symptoms caused by the disease can affect learning and attention.

As reported in a forthcoming article in the Journal of Cognitive Neuroscience, http://www.mitpressjournals.org/doi/pdf/10.1162/jocn.2010.21420, a new computational model, developed by Drs. Ahmed Moustafa and Mark Gluck, at the Center for Molecular and Behavioral Neuroscience at Rutgers University, Newark, has shown how Parkinson's disease affects attentional performance during learning.

The same model also shows that dopamine medications enhance attentional performance in Parkinson's patients in agreement with past observations. Future lab experiments with Parkinson's patients will be conducted by Moustafa and Mark Gluck to test further model predictions.

Parkinson's is a disease that mainly affects dopamine levels in a brain area known as the basal ganglia, which is important for motor control. Hence, damage to this area leads to movement disorders, including shaking and difficulty moving--key symptoms of Parkinson's disease.

Over the past two decades, it became known to neurologists and experimental neuroscientists that Parkinson's disease also affects non-motor functions, including memory, learning, and attention. Impairment in these processes affect the quality of life of the patients, thus, understanding the neural basis of motor and non-motor dysfunction in Parkinson's disease is equally important.

Dopamine is also projected to other parts of the brain, including the prefrontal cortex, an area important for higher-level thinking, decision making, and attention. Dopamine projected to the prefrontal cortex is also reduced in Parkinson's disease, as reported in many experimental studies with humans and animal models of Parkinson's disease.

According to Moustafa and Gluck, until recently, existing computational models of Parkinson's disease ignored any role played by dopamine in the prefrontal cortex. Moustafa and Gluck have designed a new computational model that shows how dopamine in the prefrontal cortex is important for attentional performance, and how dysfunction of dopamine in the prefrontal cortex can explain many of the non-motor deficits seen in Parkinson's patients.

"Computational models are increasingly being used in the neurosciences and neurology to understand how neurological disorders affect brain and behavior," said Moustafa. "This relatively new fieldknown as computational neuroscience is promising to aid in designing new pharmacological and surgical intervention tools to treat neurological and psychiatric diseases."


'/>"/>

Contact: Helen Paxton
paxton@andromeda.rutgers.edu
973-353-5262
Rutgers University
Source:Eurekalert

Related medicine news :

1. TD2 and Critical Outcome Technologies Inc. develop novel anti-cancer drug
2. New human reproductive hormone could lead to novel contraceptives
3. Researchers discover novel method for detecting MIRCERA
4. Novel detection method unmasks circulating breast cancer cells
5. Turning metal black more than just a novelty
6. Engineers, doctors at UCLA develop novel material that could help fight arterial disease
7. Novel Technology in Treating Chronic Sinus Infections Available at Baptist
8. Novel K-anonymity algorithm safeguards access to data
9. Tulane Cancer Center to begin novel clinical trial for late-stage prostate cancer drug
10. Abbott to Acquire Novel Investigational Biologic to Treat Chronic Pain
11. Dallas Facial Plastic Surgeon Publishes Cutting-Edge Novel Approach To Facelift Technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... , ... October 12, 2017 , ... On Saturday, October ... treadmill relay – Miles by Moonlight to raise money for the American Heart Association ... more. , Teams will work together to keep their treadmills moving for 5 ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... property taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, ... many overseas retirement havens have extremely low property-tax rates, which contributes to the ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: