Navigation Links
A nonantibiotic approach for treating urinary tract infections
Date:8/15/2012

WASHINGTON, Aug. 15, 2012 The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series describes a potential new approach for treating urinary tract infections (UTIs) which affect millions of people annually without traditional antibiotics. Because it involves non-antibiotic compounds, the approach would not contribute to the growing problem of antibiotic-resistant bacteria, or "superbugs."

Based on a report by Beat Ernst, Ph.D., and colleagues in ACS' Journal of Medicinal Chemistry, the new podcast is available without charge at iTunes and from www.acs.org/globalchallenges.

In the podcast, Ernst explains that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of superbugs that shrug off some of the most powerful new antibiotics.

Thus, the scientists decided to try a new approach developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection. In addition, this new class of antimicrobials is expected to have a reduced potential for the emergence of resistant microbes.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related medicine news :

1. A hands-on approach to treating patients with pulmonary disease
2. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
3. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
4. MDC researchers develop new approach to treat acute liver failure
5. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
6. Study implements community-based approach to treat HIV-infection in rural Uganda
7. Expert panel calls for new research approach to prevent youth violence
8. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
9. Researchers offer new approach to track former prisoners access to community HIV care
10. A better way to test new treatments? Approach could help patients and give useful results
11. Success of fertility treatment may approach natural birth rate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... Aliso Viejo, California (PRWEB) , ... May 28, 2016 , ... ... just need to drag and drop a preset onto their media," said Christina Austin ... from Pixel Film Studios, editors can quickly and easily add stylish color grades to ...
(Date:5/27/2016)... ... 27, 2016 , ... Southland Log Homes , designer and manufacturer of ... kits, which can be found on its website at SouthlandLogHomes.com. , The designs of ... they highlight the craftsmanship of timber post and beam construction. The result is ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Aimed at ... human interest stories, which come courtesy of leaders in the nursing and health care ... from leading advocates and associations—namely Abilene Christian University. , As the nursing industry ...
(Date:5/26/2016)... Hampshire (PRWEB) , ... May 26, 2016 , ... ... care products, has been honored with a 2016 When Work Works Award for its ... award, part of the national When Work Works project administered by the Families and ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... the necessity of health literacy within the technology advancement of diagnostic imaging. According to a ... majority of oncology patients undergo imaging screenings without understanding the nuanced risks associated with ... ... ... Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... Israel , May 27, 2016 ... of the Dario™ Diabetes Management Tool, today announced that the ... at the Marcum MicroCap Conference being held June 1-2 in ... Micro Invitational, being held June 7-9 in Los ... Ben-David will discuss recent corporate and operational milestones, including the ...
(Date:5/27/2016)... According to the 2016 report, ... ambulatory blood pressure monitoring system market growth. With aging, ... to respond to different pressure rates, leading to hypertension ... various cardiovascular disorders such as heart failure, stroke, coronary ... growing in prevalence each year. WHO estimates that 17 ...
Breaking Medicine Technology: