Navigation Links
A nonantibiotic approach for treating urinary tract infections
Date:8/15/2012

WASHINGTON, Aug. 15, 2012 The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series describes a potential new approach for treating urinary tract infections (UTIs) which affect millions of people annually without traditional antibiotics. Because it involves non-antibiotic compounds, the approach would not contribute to the growing problem of antibiotic-resistant bacteria, or "superbugs."

Based on a report by Beat Ernst, Ph.D., and colleagues in ACS' Journal of Medicinal Chemistry, the new podcast is available without charge at iTunes and from www.acs.org/globalchallenges.

In the podcast, Ernst explains that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of superbugs that shrug off some of the most powerful new antibiotics.

Thus, the scientists decided to try a new approach developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection. In addition, this new class of antimicrobials is expected to have a reduced potential for the emergence of resistant microbes.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related medicine news :

1. A hands-on approach to treating patients with pulmonary disease
2. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
3. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
4. MDC researchers develop new approach to treat acute liver failure
5. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
6. Study implements community-based approach to treat HIV-infection in rural Uganda
7. Expert panel calls for new research approach to prevent youth violence
8. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
9. Researchers offer new approach to track former prisoners access to community HIV care
10. A better way to test new treatments? Approach could help patients and give useful results
11. Success of fertility treatment may approach natural birth rate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... After a long health ... a new lease on life with assistance from CreditAssociates. CreditAssociates provides debt relief ... with unsecured debt. The senior is one of the satisfied clients who expressed ...
(Date:9/22/2017)... ... September 22, 2017 , ... Happy Living’s mission - to improve the health ... into the entertaining and delicious worlds of theatre and wines. , After watching ... him to turn his play into a book. The Greener The Grass ( https://www.happyliving.com/books/the-greener-the-grass ...
(Date:9/22/2017)... ... September 22, 2017 , ... TopConsumerReviews.com recently ... Native Remedies that helps promote pancreatic health and regulate blood sugar levels ... prescription-based approaches can have negative side effects, and with the changes in today’s ...
(Date:9/22/2017)... ... September 22, 2017 , ... Silicon Valley startup Enke ... the go. Their electric toothbrushes aggressively attack oral bacteria by reducing dental plaque ... Combining leading edge Enke technology with a premium timeless design, they want to ...
(Date:9/22/2017)... ... September 22, 2017 , ... The freshly ... customers’ doorstep. According to Smart Mart, customers can now order vegetable, fruit, snacks, ... and customers can find clothing at discounted prices. Apart from this, Smart Mart ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
(Date:9/7/2017)... Calif. , Sept. 7, 2017  For nearly two decades, New ... in the Assisted Reproduction Insurance industry. Today, New Life Agency announces a ... medications. ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ... ...
(Date:9/6/2017)... , Sept. 6, 2017  Robert G. Szewc, ... Pinnacle Professional Member in recognition of his contributions to ... serves as a Nephrologist at the practice of Kidney ... medicine, kidney care and hypertension solutions. He has worked ... years of career experience, as well as expertise in ...
Breaking Medicine Technology: