Navigation Links
A non-antibiotic approach for treating urinary tract infections
Date:6/20/2012

A potential new approach for treating urinary tract infections (UTIs) which affect millions of people annually without traditional antibiotics is being reported in ACS' Journal of Medicinal Chemistry. It involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.

Beat Ernst and colleagues explain that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of "superbugs" that shrug off some of the most powerful new antibiotics. Thus, the scientists decided to try a new approach developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection and, furthermore, this new class of antimicrobials is expected to exhibit less selection pressure and, therefore, a reduced potential for the emergence of resistance.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances, an indolinylphenyl mannoside, prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose of 25 g per mouse reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.


'/>"/>
Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. Unique approach needed to accurately assess health of young adult cancer survivors
2. MU receives national award for using mind-body approach to improve health
3. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
4. Editorial calls for comprehensive approach to cancer screening
5. Rutgers team discovers novel approach to stimulate immune cells
6. National initiative launched to change the way biology departments approach undergraduate education
7. A systems approach to preventing obesity in early life
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
10. Study Suggests Treating Dyslexia Before Kids Learn to Read
11. New standards for treating traumatic shoulder injuries to improve patient care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... The automated external defibrillator market ... categories - semi-automated and fully automated defibrillators. Based ... categories, namely, hospitals, pre-hospital, public access, alternate care, ... Automated external defibrillators play an important role in ... Considering the life-saving potential of AEDs, legislations requiring ...
(Date:5/20/2013)... new healthcare bill proposes to have major ramifications in ... all the conditions were to be implemented or have ... 2014 to show anything. , According to Health ... forward to implement the health care law and establishing ... and West Virginia. HHS will continue to provide the ...
(Date:5/20/2013)... 20, 2013 Eben Pagan's ... the public creating a frenzy among business owners ... elite business training. WealthSpringMarketing.com's Tiffany Hendricks has published ... an exclusive bonus. , "Eben Pagan is a ... training to individuals serious about success," reports Hendricks. ...
(Date:5/20/2013)... According to a May 6, 2013 CBS ... Salons,” tanning salons in the US may soon ... Administration wants to see cancer warnings on indoor tanning ... of eighteen for the use of indoor tanning and sun ... has become increasingly common over the last few decades (Go ...
(Date:5/20/2013)... Lake City, UT (PRWEB) May 20, 2013 ... named one of Select Health’s Select 25 winners ... receive $2500 from Select Health. Know Greater Heroes is a ... local elementary schools to teach children how to eat right, ... student athletes participate in the Know Greater Heroes program each ...
Breaking Medicine News(10 mins):Health News:North America Leads Automated External Defibrillator Market (AED), Says New Research Report at ReportsnReports.com 2Health News:North America Leads Automated External Defibrillator Market (AED), Says New Research Report at ReportsnReports.com 3Health News:Review of Health Bill Impact in 2014 2Health News:Review of Health Bill Impact in 2014 3Health News:Eben Pagan's Accelerate: Review and Bonus Released By WealthSpringMarketing.com 2Health News:Tanning - FDA Wants Tanning Salons to Post Cancer Warning Signs 2Health News:SLCC Know Greater Heroes Program Named to Select 25 2Health News:SLCC Know Greater Heroes Program Named to Select 25 3
... Hologic, Inc. (Nasdaq: HOLX ) today announced that Glenn ... Global Healthcare Unplugged Conference in New York City on Tuesday, September ... Interested parties are invited to listen to a live audio ... company,s website at www.hologic.com/investor . An archive of ...
... , , , ... (Nasdaq: ZIXI ), the leader in email encryption services, today ... is a two-year extension of Humana,s original agreement which has now spanned ... ZixCorp licenses bringing the total to 36,000. , , ...
... in the September 2009 issue of the Journal of ... life prior to treatment can help predict the overall survival ... For those with advanced stage NSCLC, the median overall ... of patients surviving past the one year mark. To better ...
... study, approximately 20% of U.S. soldiers returning from Iraq ... substantial number with post-traumatic stress disorder (PTSD), and the ... unacceptable to Army commanders and the soldiers, families. ... doctors will now be able to forecast a soldier,s ...
... discounts, special promotions lead to greater alcohol consumption, study shows ... college bars lead to more intoxicated students and more health ... news that college students drink and the results can be ... the impact of drink discounts at college bars and found ...
... , , , WASHINGTON, Sept. ... flu, or H1N1 outbreak, in a recent article . , ... of the Mexican government in the fields of public awareness, rapid ... , The article noted "Mexico,s most effective action ...
Cached Medicine News:Health News:Zix Corporation and Humana Renew and Expand Exclusive Agreement 2Health News:Keeping the suicidal soldier alive 2Health News:College Students Get More Drunk When Drinks Are Cheap 2
(Date:5/20/2013)... -- Neuralstem, Inc. (NYSE MKT: CUR) today reported that ... presented updated Phase I data from its spinal cord-derived ... of amyotrophic lateral sclerosis (ALS or Lou ... medical symposium in Bucharest, Romania , ... in Stem Cell Therapy," Dr. Feldman outlined the design ...
(Date:5/20/2013)... CHICAGO, Ill. , May 20, 2013 /PRNewswire/ ... the initiation of a Phase 3 clinical study ... to assess the effects of the investigational compound ... progression of kidney disease in patients with stage ... type 2 diabetes.  SONAR is a large, multinational, ...
(Date:5/20/2013)... , May 20, 2013 With herbal medicines ... available from the U.S. Pharmacopeial Convention (USP) will provide ... of the herbal ingredients used in these products. Today, ... in the new Herbal Medicines Compendium ( ... at hmc.usp.org . HMC ...
Breaking Medicine Technology:Neuralstem ALS Trial Principal Investigator, Dr. Eva Feldman, Presented Phase I Data At The Neuro Diabetes Medical Symposium In Romania 2Neuralstem ALS Trial Principal Investigator, Dr. Eva Feldman, Presented Phase I Data At The Neuro Diabetes Medical Symposium In Romania 3Neuralstem ALS Trial Principal Investigator, Dr. Eva Feldman, Presented Phase I Data At The Neuro Diabetes Medical Symposium In Romania 4AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 2AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 3AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 4AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 5AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 6New Compendium Offers Freely Available Testing Standards to Help Ensure the Quality of Herbal Ingredients Used in Traditional Medicines 2New Compendium Offers Freely Available Testing Standards to Help Ensure the Quality of Herbal Ingredients Used in Traditional Medicines 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: