Navigation Links
A new weapon for attacking tumor invasion and metastasis
Date:6/17/2008

In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration. This study, performed by a team led by Professor Ji-Kun Li from the Shanghai Jiao Tong University is described in a research article to be published on April 21, 2008 in the World Journal of Gastroenterology.

Colorectal cancer (CRC) is one of the main causes of cancer-related death in the world. The mortality of CRC is principally attributed to the development of liver and other metastases. It may be helpful for doctors to find a new biomarker that predicts early recurrence or distant organ metastasis. There is also a pressing need for more effective treatments for patients with advanced colorectal cancer.

In the view of the authors, their research has shown elevated CXCR4 (a new receptor on cancer cells) expression in primary CRC is associated with liver and lymph node metastasis, which prompts them to elucidate the mechanism of this phenomenon. They also found AMD3100 had significant antitumor activity through regulating pathways downstream of CXCR4 and impaired formation of tumor micro vessels and expression of invasive associated genes.

Inhibition of CRC cells survival and metastatic spread by interfering with the ligand- receptor axis has been successful in vitro. Though these data do not necessarily predict a satisfactory outcome of clinical trials, they provide a novel strategy based on this new molecule pair.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Potential viral therapy weapon for difficult cancers is safe and effective in study
2. New World Record Holder in Powerlifting Credits NutraCeas Unique Rice-Bran-derived Product as his Secret Weapon
3. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
4. Research May Yield New Weapons Against Sepsis
5. Barrier Technology Provides New Weapon in MRSA War: Surface Care Products Prevent Growth and Transfer of Bacteria
6. Schools Have New Weapon for Head Lice Screening
7. Early predictive model may be new weapon against leading cause of death on battlefield
8. Drug a New Weapon Against One Form of Breast Cancer
9. Indoor Tanning Association Launches Campaign Attacking Melanoma Hype
10. New type of drug shows promise in attacking melanoma in an innovative way
11. Ability to track stem cells in tumors could advance cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... The improved access to antiretroviral drugs ... developing world, has led to the decline in the ... due to AIDS globally. However, despite the fact that ... patients becoming affected by the virus is on the ... all related organisations and stakeholders, by 2015, significant investments ...
(Date:8/22/2014)... NJ. August 22, 2014. A new study ... persons with multiple sclerosis (MS) may be able ... The study was epublished ahead of print on ... Helen Genova, Hali Griswold, Nancy D. Chiaravalloti & ... persons with multiple sclerosis doi: 10.3233/NRE-141113). Self-awareness is ...
(Date:8/22/2014)... CLEVELAND Renal artery stenting to open blockages ... have historically been excluded from modern clinical trials, ... e-published in Catheterization and Cardiovascular Interventions ... Interventions (SCAI). , University Hospitals Case Medical Center,s ... and Professor of Medicine, Case Western Reserve University ...
(Date:8/22/2014)... 22, 2014 Home Care Assistance ... care for seniors, is proud to announce the next ... upcoming webinar will feature Dr. Suzanne Steinbaum, attending cardiologist ... Hospital in New York City, National Spokesperson for the ... webinar will cover the issues surrounding women and heart ...
(Date:8/22/2014)... Many children get anxious or afraid when they have ... of ways that parents can make these shots easier ... step is to explain to children in an age-appropriate ... Rita John, director of the pediatric primary care nurse ... New York City. "Children need to know that ...
Breaking Medicine News(10 mins):Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3Health News:Simple Steps Make Shots Less Scary for Kids, Nurse Says 2
... Avon Global Ambassador,Reese Witherspoon, will travel to Sao ... first-ever global fundraising product, the Women,s,Empowerment Bracelet, which ... Reese will be joined by female luminaries, ... Falu, UNIFEM Regional Director,for the Southern Cone, and ...
... not,women and men have different oral health needs. In ... their life, including,puberty, pregnancy and menopause., The Pennsylvania ... oral health needs will ensure that everyone,regardless of gender ... care they,need to maintain healthy teeth and gums., ...
... reactor facility at Petten in the Netherlands threatens the ... obtain radioactive isotopes, which are critical for performing many ... worldwide. The shutdown at the High Flux Reactor in ... the National Research Universal reactor in Chalk River, Canada ...
... Aug. 27 The National Labor,Relations Board issued ... from the Easton facility had filed a series ... threatening,retaliating against workers, and attempting to bribe workers ... real improvements. They,re,trying to buy us off by ...
... 27 Stand Up For A Cure,s 2008,Concert Series ... a,performance by Grammy(R)-winning Dave Matthews Band at Madison Square,Garden. ... be hosted,by Julia Roberts and will be preceded by ... New York-based non-profit, Stand Up For A Cure created ...
... of Charity Health System Continues to Jeopardize Patient ... Thousands of,healthcare workers will hold a one-day strike ... the Daughters of Charity Health System.,Caregivers were forced ... fairly over proposals aimed to help ensure quality ...
Cached Medicine News:Health News:Reese Witherspoon Visits Brazil to Spread Message of Female Empowerment as Avon's Global Ambassador 2Health News:What You Need to Know About Women's Oral Health 2Health News:SNM expresses serious concerns as isotope shortage looms 2Health News:SNM expresses serious concerns as isotope shortage looms 3Health News:Carlyle-ManorCare Facing New Federal Charges for Breaking the Law: Interrogating, Threatening, Retaliating Against Nursing Home Workers for Trying to Form a Union 2Health News:Julia Roberts Joins Dave Matthews Band at Madison Square Garden in 'Stand Up For A Cure' 2008 Concert Series 2Health News:Thousands of California Healthcare Workers Strike to Protect Their Patients 2
(Date:8/22/2014)... MC Medical, a subsidiary of Mitsubishi Corporation (MCM), ... OH medical device company, have formally agreed to ... visualization system in Japan . It is ... Japan in the latter half of 2015. ... product portfolio in endoscopic surgery market in Japan ...
(Date:8/22/2014)... , Cali ., Aug. 22, 2014 ... Papillomavirus Conference shows that a therapy being developed by Hera ... two that cause 70 percent of all cervical cancer. ... blocked the replication of HPV-16, HPV-18 and HPV-11 cells, according ... Broker , Ph.D., who presented the findings at the ...
(Date:8/22/2014)... 2014  Landauer, Inc. (NYSE: LDR ), ... and monitoring, outsourced medical physics services and high quality ... Saxelby , its President and Chief Executive Officer, will ... and as a member of the Board of Directors, ... replaced on an interim basis by Michael T. ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2Landauer, Inc. Announces Executive Management Change 2
... 12, 2011 Aribex, Inc., the worldwide leader in ... Award from the internationally-known 2011 Edison Best New Product ... ceremony at the historic Capitale ballroom in New York ... recognized in the Science and Medical Handheld or Miniaturized ...
... Asante Solutions, Inc. (Asante), a medical device company focused ... mark for its Pearl Insulin Pump, the only insulin ... mark is a European proof of conformity that certifies ... Asante has begun discussions with potential distribution partners in ...
Cached Medicine Technology:NOMAD by Aribex Receives Edison Best New Product Award 2Asante Solutions, Inc. Receives CE Mark for Pearlâ„¢ Insulin Pump 2
Honing compound for knife sharpening, 6 grams net...
Conversion kit that has 1 - 15 micron feed screw with 1 micron increments for fine cutting (factory fitted)...
Knife sharpening kit...
... is necessary to cool a specimen below room ... to most microtomes and will permit specimen cooling ... conditions. The equipment consists of a cooling stage ... best suited for operation with a base sledge ...
Medicine Products: