Navigation Links
A new way of looking at drug discovery
Date:2/17/2013

PHILADELPHIA - Garret FitzGerald, MD, FRS, chair of the Department of Pharmacology and Director of the Institute for Translational Medicine & Therapeutics, Perelman School of Medicine at the University of Pennsylvania, has long said the current drug-development system in the United States is in need of change, "representing an unsustainable model."

Even though the number of drugs approved has risen in the last three years, overall, roughly the same number of drugs have been approved by the Food and Drug Administration (FDA) each year since 1950 while the estimated cost, mostly because of the failure to bring new medicines all the way to market - has exploded.

As the dominance of large pharma erodes and the process of drug discovery and development moves to a more modular approach, initiatives such as the NIH's Clinical and Translational Science Awards are designed to enhance the ability of academia to play in this space.

Novel approaches to raising capital and to distributing intellectual property are also emerging.

However, most failures in drug development now occur during phase 2 clinical trials, when the mechanism of drug action is discovered and the factors that contribute to variability in drug response are parsed. We are challenged by a paucity of those individuals who integrate knowledge of preclinical science with an understanding of the complexity of drug action in humans. The relative absence of such individuals who serve as catalysts in drug development is apparent in big pharma, academia and at the FDA.

A politically uncontroversial role for NIH's National Center for Advancing Translational Sciences would be to address this problem, giving academia incentives to couple initiatives in translational medicine and therapeutics and in regulatory science to create a cadre of such individuals. This interdisciplinary group could catalyze drug development by including strategies focused on a more personalized approach, improving prediction of efficacy and safety and becoming a source of information about therapy for prescribers and consumers that exceeds the "objectivity" of direct to consumer advertising.

FitzGerald will present "A New Paradigm for Therapeutics Discovery" at the 2013 American Association for the Advancement of Science Annual Meeting in Boston, as a part of the Sunday, February 17th session, "Cultivating the Science and Scientists for 21st Century Drug Discovery and Development."

Symposium Time
Sunday, February 17, 2013
8:00 AM-9:30 AM
Room 207 Hynes Convention Center


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Merrill DataSite Announces a New Article "Due Diligence Tips for SMEs Looking for Venture Capital" on its Website
2. Advanced Hearing Center Announces Special Offer: Complimentary Hearing Aid Batteries for Residents Looking for Hearing Aids in NYC
3. myMEDholiday Comes up with a New Highly Credible Informative Website for Users Looking for Affordable Healthcare Centers Abroad
4. A new way of looking at Prader-Willi Syndrome
5. Looking for the anti-Alzheimers molecule -- A new approach to treating a devastating disease
6. Healthy-Looking Pigs at State Fair Found to Have Swine Flu
7. Looking to Lose Weight?
8. Why do older adults display more positive emotion? It might have to do with what they’re looking at
9. Scientists looking for noninvasive ways to detect lung cancer early
10. Discovery in HIV may solve efficiency problems for gene therapy
11. Chili peppers spark discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating ... , As the stress of modern life continually makes more demands on time and ... artificial stimulants can trap people in vicious high/low cycles and can also cause long ...
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is not as popular ... begun providing weekend displays, and numerous households celebrate the unofficial end of summer with ... terrifying for pets. , Kris Zambo, owner of Dynamite Fireworks in ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... risk to health and safety. By learning and implementing best practices for containment ... In this webinar, attendees will gain a better understanding of a method for ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... of two plastic surgery fellows for academic year 2017-2018, Christina M. Busuito, M.D. ... have successfully completed residency in Plastic and Reconstructive Surgery. The candidate will ...
(Date:8/21/2017)... MINNEAPOLIS, MINN (PRWEB) , ... August 21, 2017 ... ... Sports Group, today announced that it has become the Official Technology Partner of ... their AES (Advanced Event Systems) volleyball software, along with providing sport ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... its Board of Directors has approved the payment of a ... 2017. The cash dividend ... October 27, 2017 to stockholders of record as of the ... dividends are subject to approval of the Board of Directors ...
(Date:8/7/2017)... 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest ... June 30, 2017.  All comparisons, unless otherwise noted, are to ... Second Quarter 2017 Highlights include: ... an increase of 3.5% Total prescriptions dispensed ... of 7.5% versus 7.6% Gross profit ...
(Date:8/4/2017)... ROCKVILLE, Md. , Aug. 4, 2017 ... during or shortly after a physician/patient consult has long ... industry, and was a notable focus of the largest ...  This is according to healthcare market research firm Kalorama ... of care testing (POCT) offerings or related supplies and ...
Breaking Medicine Technology: