Navigation Links
A new understanding of why seizures occur with alcohol withdrawal
Date:10/17/2009

CHICAGO Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long-term or chronic drinking habit. Researchers have shown that the flow of calcium ions into brain cells via voltage-gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures. But do the changes in calcium currents contribute to alcohol withdrawal seizures or are they a consequence of the seizures?

Using a careful analysis of correlations between the course of alcohol withdrawal seizures and the expression of calcium currents, Georgetown University Medical Center researchers found that the enhancement of total calcium current density in pre-clinical animal studies occur prior to the onset of alcohol withdrawal seizures. The research presented at 39th annual meeting of the Society for Neuroscience also shows that calcium currents remain enhanced during the period of seizure susceptibility, but return to control levels when the period of seizure susceptibility is over.

"These preliminary findings are the first to indicate that altered calcium channel activity contributes to the occurrence of alcohol withdrawal seizures," explains lead author, Prosper N'Gouemo, PhD, an assistant professor in the department of pediatrics at GUMC. "The next step in our research is to determine which types of voltage-gated calcium channels contribute to the enhanced current density that takes place before the onset of alcohol withdrawal seizures so a potential treatment can be developed."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Informational handout key to giving parents a better understanding of CT radiation risks
2. Updated GOLD report presents new understandings in diagnosis, treatment and prevention of COPD
3. New understanding of basic units of memory
4. Optical scientist honored for understanding and improving vision
5. Increased Understanding Called for During November National Alzheimers Disease Awareness Month by Los Angeles Jewish Homes Medical Director
6. Understanding of Mammography Differs Among Races
7. Canadian Pacific and Mayo Clinic Build Understanding and Commit to Ongoing Dialogue
8. Understanding College Student Mental Health: The Psychological, Institutional and Legal Issues
9. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
10. Understanding the have-knots: The role of stress in just about everything
11. Revolution in understanding of ion channel regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... ... Saad B. Chaudhary, MD is committed to providing the highest quality of spine care to ... preventative care with all my patients to alleviate possible future issues. I am pleased to ... my office and my trained staff will assist you in any way possible.” , Dr. ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol ... is introducing Flexadin UCII, part of the EQUISTRO line, at this week’s Rolex ... in horses at the immunologic level. , The scientifically-developed Flexadin UCII supports the ...
(Date:4/24/2017)... ... ... Michael Vick announced his retirement earlier this year from the NFL after thirteen ... in the 2001 NFL Draft, to the Atlanta Falcons, made four Pro Bowl appearances ... yards by a quarterback (6,109) and the most rushing yards by a quarterback in ...
(Date:4/24/2017)... ... April 24, 2017 , ... NEPC Director Kevin Welner has ... Research Award. The award honors scholars exemplary in their capacity to communicate important ... has demonstrated the capacity to deepen the public’s understanding and appreciation of the ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Sean Fay ... Oxiclean, Space Bag, Sonicare Toothbrush, Juiceman Juicer, and the George Foreman Grill (which sold ... any other marketer in the last 25 years. , Now, due to changes in ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... -- New research provides evidence that an old drug may provide ... released today that will be presented at the American ... Boston , April 22 to 28, 2017. ... the oral drug levodopa has long been considered the gold ... disease progresses, the effects of the medication can partially wear ...
(Date:4/19/2017)... April 19, 2017  SARES•REGIS Group leased the ... developing at Conejo Spectrum Business Park in ... Atara Biotherapeutics, Inc. , a biopharmaceutical company developing ... diseases that have been underserved by scientific innovation, ... for cancer, autoimmune and infectious disease. ...
(Date:4/18/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical ... Gynecology markets with innovative and proprietary products, will release ... 2017 after the market close on Tuesday, May 2, ... conference call and webcast to discuss its financial results ... 4:30 p.m. Eastern Time (3:30 p.m. Central Time). ...
Breaking Medicine Technology: