Navigation Links
A new understanding of why seizures occur with alcohol withdrawal
Date:10/17/2009

CHICAGO Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long-term or chronic drinking habit. Researchers have shown that the flow of calcium ions into brain cells via voltage-gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures. But do the changes in calcium currents contribute to alcohol withdrawal seizures or are they a consequence of the seizures?

Using a careful analysis of correlations between the course of alcohol withdrawal seizures and the expression of calcium currents, Georgetown University Medical Center researchers found that the enhancement of total calcium current density in pre-clinical animal studies occur prior to the onset of alcohol withdrawal seizures. The research presented at 39th annual meeting of the Society for Neuroscience also shows that calcium currents remain enhanced during the period of seizure susceptibility, but return to control levels when the period of seizure susceptibility is over.

"These preliminary findings are the first to indicate that altered calcium channel activity contributes to the occurrence of alcohol withdrawal seizures," explains lead author, Prosper N'Gouemo, PhD, an assistant professor in the department of pediatrics at GUMC. "The next step in our research is to determine which types of voltage-gated calcium channels contribute to the enhanced current density that takes place before the onset of alcohol withdrawal seizures so a potential treatment can be developed."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Informational handout key to giving parents a better understanding of CT radiation risks
2. Updated GOLD report presents new understandings in diagnosis, treatment and prevention of COPD
3. New understanding of basic units of memory
4. Optical scientist honored for understanding and improving vision
5. Increased Understanding Called for During November National Alzheimers Disease Awareness Month by Los Angeles Jewish Homes Medical Director
6. Understanding of Mammography Differs Among Races
7. Canadian Pacific and Mayo Clinic Build Understanding and Commit to Ongoing Dialogue
8. Understanding College Student Mental Health: The Psychological, Institutional and Legal Issues
9. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
10. Understanding the have-knots: The role of stress in just about everything
11. Revolution in understanding of ion channel regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 2014 Ticket Down is a reliable ... Denver at the Sports Authority Field on July 26th. For ... Challenge) has brought some of the best club teams from around ... Cup still being raved about weeks after its completion, fans – ... some of the biggest stars in the world compete. Some of ...
(Date:7/24/2014)... 2014 The report, “Content Delivery ... market into various sub-segments with an in-depth analysis ... drivers and restraints for this market with insights ... market data tables and 36 figures spread through ... Networks (CDN) Market” at http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . ...
(Date:7/24/2014)... York (PRWEB) July 24, 2014 ... ( http://www.injurybeacon.com/granuflo-dialysis/lawsuit/ ) in the U.S. District ... protective order for plaintiff medical information covered by ... According to the July 16th Order, U.S. District ... for Fresenius Medical Care the right to ...
(Date:7/24/2014)... 24, 2014 In a July 9th article ... founder of Lotus Blossom Consulting LLC , was quoted ... Three Ways to Cut the High Cost of Infertility . ... costs is to maximize your chance of success from the ... a clinic. , “I am always happy to talk ...
(Date:7/24/2014)... of Association Executives (ASAE) announced its 2014 Power of ... American Society of Anesthesiologists (ASA). , The ASA ... A Gold Award, one of the top honors from ... of the world through education on the global anesthesia ... care. , ASA was also honored with a Power ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3
... Computer Sciences,Corporation (NYSE: CSC ) today ... to,a global information technology (IT) applications management ... the five-year agreement, CSC will continue to ... Sun,s business,applications portfolios -- including finance, manufacturing, ...
... National Institute of Environmental Health Sciences (NIEHS), part ... a total of $6.8 million for the first ... called DISCOVER - Disease Investigation Through Specialized Clinically-Oriented ... are expected to bridge the gap between basic ...
... Company Returns to Commercial Operations, SEATTLE, Dec. ... today announced that it has completed its,acquisition of ... responsibility for marketing, sales, and development of the ... be sold outside the United,States by Bayer Schering ...
... to hay fever and other allergic reactions, by preventing ... discovered by scientists. Researchers hope their finding, published today ... will allow therapies to be developed that treat allergies ... that a gene known as GATA-3 can block the ...
... vessels that supply tumors slows the progression of ... large clinical trial of Avastin, an anti-angiogenic therapy. ... of the New England Journal of Medicine, found ... progression-free survival for women with breast cancer compared ...
... While study results are promising, they don,t address benefits ... -- A treatment that wipes out abnormal heart tissue ... have defibrillators implanted after heart attacks, a new trial ... going when it slips into abnormal rhythms, they are ...
Cached Medicine News:Health News:CSC Signs Extension to Managed Applications Services Agreement With Sun Microsystems 2Health News:NIEHS awards DISCOVER grants 2Health News:NIEHS awards DISCOVER grants 3Health News:Cell Therapeutics, Inc. (CTI) Completes Acquisition of Lymphoma Drug Zevalin(R) From Biogen Idec for Sales and Marketing in the United States 2Health News:Cell Therapeutics, Inc. (CTI) Completes Acquisition of Lymphoma Drug Zevalin(R) From Biogen Idec for Sales and Marketing in the United States 3Health News:Cell Therapeutics, Inc. (CTI) Completes Acquisition of Lymphoma Drug Zevalin(R) From Biogen Idec for Sales and Marketing in the United States 4Health News:Cell Therapeutics, Inc. (CTI) Completes Acquisition of Lymphoma Drug Zevalin(R) From Biogen Idec for Sales and Marketing in the United States 5Health News:Fight against hay fever and other allergies helped by new immune system discovery 2Health News:Bevacizumab found to improve survival for patients with advanced breast cancer 2Health News:Heart Procedure Reduces Need for Defibrillator Shocks 2Health News:Heart Procedure Reduces Need for Defibrillator Shocks 3
(Date:7/24/2014)... OAKS, Calif. , July 24, 2014 Amgen ... report its second quarter financial results on Tuesday, July 29, ... announcement will be followed by a conference call with the ... from Amgen will be Robert A. Bradway , chairman ... management team. Live audio of the conference call ...
(Date:7/24/2014)... Inc. (NYSE MKT: IG), a New Jersey based specialty generic ... the second quarter ended June 30, 2014. Second ... million in the second quarter of 2014, an increase of ... revenues of $13.3 million for the six months ended June ... in 2013 , Total revenues generated from the sale ...
(Date:7/24/2014)... 2014  Alimera Sciences, Inc. (NASDAQ: ALIM ... research, development and commercialization of prescription ophthalmic pharmaceuticals, today ... fiscal year 2014 financial results after the market close ... will follow on the same day at 4:30 p.m. ... hosted by Dan Myers , President and Chief ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Second Quarter Financial Results 2IGI Laboratories Announces Second Quarter 2014 Results 2IGI Laboratories Announces Second Quarter 2014 Results 3IGI Laboratories Announces Second Quarter 2014 Results 4IGI Laboratories Announces Second Quarter 2014 Results 5IGI Laboratories Announces Second Quarter 2014 Results 6IGI Laboratories Announces Second Quarter 2014 Results 7Alimera Sciences To Release Second Quarter 2014 Results 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: