Navigation Links
A new tool to confront lung cancer
Date:6/19/2014

Only 15% of patients with squamous cell lung cancer the second most common lung cancer survive five years past diagnosis. Little is understood about how the deadly disease arises, preventing development of targeted therapies that could serve as a second line of defense once standard chemotherapy regimens fail.

Published online in Cell Reports on June 19, Huntsman Cancer Institute investigators report that misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice. The discovery uncovers new treatment strategies, and provides a clinically relevant mouse model in which to test them.

"This is the most exciting thing we've done," said senior author Trudy Oliver, Ph.D., an assistant professor of oncological sciences at the University of Utah and Huntsman Cancer Institute investigator. "Now that we have a model it unleashes so many questions we can ask to gain a better understanding of the disease."

By definition, tumors are groups of cells that are out of control. As a result, they acquire mutations, only some of which drive properties such as excess growth and motility - that make cells cancerous. The trick for developing targeted therapies is to distinguish the "driver" from "passenger" mutations that are merely along for the ride.

Call it guilt by association, but Oliver's team honed in on drivers of squamous cell carcinoma (SCC) of the lung by poring through documented gene abnormalities found in human SCCs. Sox2 was designated a prime candidate based on its overexpression in 60-90% of SCCs, and a frequent early appearance during tumor formation, suggesting it could be an initiator of cancer. Tumor suppressor genes were also candidates, including Lkb1, which is mutated in 5-19% of SCCs.

While disruption of either gene alone failed to trigger cancer, combining overexpression of sox2 in the lung with loss of lkb1 led to frequent development of lung SCC in mice.

"A pathologist
'/>"/>

Contact: Linda Aagard
Linda.Aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Disabled shoppers confront holiday shopping barriers
2. Study Suggests Vaccine May Help Kids With Brain Cancer
3. New Stool Test Might Aid in Early Detection of Colon Cancer
4. Study reveals how cancer drug causes diabetic-like state
5. How a cancer drug leads to diabetes
6. You Survived Cancer: Now Pay Attention to Your Overall Health
7. New drug prevents spread of human prostate cancer cells
8. Eliminating the good cholesterol receptor may fight breast cancer
9. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
10. Experimental Chemo Combo for Colon Cancer Disappoints
11. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new tool to confront lung cancer
(Date:4/24/2015)... Joseph, Missouri (PRWEB) April 24, 2015 ... for veterinarians , UGA is now proud to be ... the care of 16,000 animals a year. This partnership ... care for their animals. , After providing an ... Missouri Veterinary Medical Teaching Hospital (VMTH) wanted to increase ...
(Date:4/24/2015)... IntelliSoft Group, LLC, a leading provider ... software, featured IntelliCred Version 14.2 during the ... Educational Conference (IAMSS) on April 23-24 at the ... , Notable improvements available in IntelliSoft’s Version 14.2 ... Contract Linking: A new Contract Connection Tab connects ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Telematics Berlin ... together automakers, tier 1 & 2 suppliers, content providers, ... key players in the value chain, see them converge ... to not only hear from those companies currently at ... their future partners. Working on customer centric products, ParkTAG ...
(Date:4/24/2015)... 24, 2015 Yisrayl Hawkins, Pastor and Overseer ... explaining the reason armed forces are used worldwide, and how ... Bible were kept. Yisrayl says that the nations have been ... they have only added to the confusion and distrust. ... protect themselves against captivity, forced compliance, unjust rules and laws, ...
(Date:4/24/2015)... April 24, 2015 Recent research by ... that Physical therapists and their assistants are among the ... greatest growth by the year 2023. , Physical ... the strongest growth and greatest potential for expansion in ... beck revealed that while physical therapists can offer great ...
Breaking Medicine News(10 mins):Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:IntelliSoft Group Version 14.2 of IntelliCred featured at the Illinois Association of Medical Staff Services Annual Educational Conference 2Health News:Telematics Berlin 2015’s inaugural European Automotive Start-Up Competition 2Health News:Telematics Berlin 2015’s inaugural European Automotive Start-Up Competition 3Health News:Armed Forces Would Not Be Necessary if Biblical Laws Were Followed, Says Yisrayl Hawkins in New Article 2Health News:Huntsville Medical Doctor Explains Why Physical Therapy May Not Treat Muscle Numbness Adequately 2
... of seizures in study participants, , THURSDAY, March 18 ... of epileptic seizures in people who had not responded ... The electrical stimulation came from a pacemaker-like device that ... wall. Electrical leads from the device ran under the ...
... , ... , ... ... BLOOMINGTON, Minn. , March 18 As part of National Colorectal Cancer Awareness Month, ...
... ... Bioactive Beverage , ... (Vocus) March 18, 2010 -- Tahitian Noni International (TNI) announced the introduction of ... of any Tahitian Noni product with 16 different iridoids ., , , , ,Age, ...
... ... and Offers Spa Treatments to Those Living with Cancer. ,She provides oncology patients with the ... effects of cancer treatment and therapies, customized to suit their individual needs, at her wonderfully ... ...
... ... about defective products, dangerous drugs, and unfair business practices. With this resource, visitors to ForThePeople.com ... ... Morgan and Morgan is dedicated to protecting the rights of consumers who have been ...
... 18, 2010)Researchers evaluating France,s national infection control program ... rates of healthcare-associated infections (HAIs) since 2004. The ... infections, could be attributed to important changes in ... regional and local coordinating centers have been reorganized ...
Cached Medicine News:Health News:Implant Shows Promise for Hard-to-Treat Epilepsy 2Health News:Minnesota Organizations Join Together to Save 500 Lives 2Health News:Minnesota Organizations Join Together to Save 500 Lives 3Health News:Minnesota Organizations Join Together to Save 500 Lives 4Health News:Minnesota Organizations Join Together to Save 500 Lives 5Health News:Tahitian Noni Extra Released With 16 Different Iridoids 2Health News:Peace of Mind Skin Care Announces new Services in Oncology Esthetics 2Health News:Morgan and Morgan Provides Consumer Alert Center with Information about Dangerous Products 2Health News:France's national program to reduce HAIs reports important successes; uses mandatory reporting 2Health News:France's national program to reduce HAIs reports important successes; uses mandatory reporting 3
(Date:4/24/2015)... , April 24, 2015   Bernstein ... Pharmaceuticals, Inc. ("Aerie" or the "Company") (NASDAQ: ... to investors in violation of the federal securities ... Aerie breached their fiduciary duties to shareholders. ... on the discovery, development and commercialization of first-in-class ...
(Date:4/24/2015)... PORTLAND, Ore. , April 24, 2015  A new ... in the costs of drugs used to slow the progression ... to a study led by researchers at Oregon Health & ... A substantial increase in the number of MS drugs in ... lead to lower or stabilized costs for patients who use ...
(Date:4/24/2015)... 24, 2015   Vestagen Technical Textiles, Inc. ... , has recently received two notable innovation awards. The ... that recognizes innovations with potential to create a positive ... in New York City , VESTEX ... "Protection & Safety" category. The awards honor excellence in ...
Breaking Medicine Technology:Bernstein Liebhard LLP Investigates Claims On Behalf Of Those Who Invested In Aerie Pharmaceuticals, Inc. 2Researchers find alarming rise in cost of MS drugs over past two decades 2Researchers find alarming rise in cost of MS drugs over past two decades 3Researchers find alarming rise in cost of MS drugs over past two decades 4VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 2VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 3
... Application for AML Remission Maintenance Therapy ... Advances on Schedule Following Meeting with EMEA, ... and OMX Nordic Exchange: EPCT) today reported that ... application for,its lead oncology product Ceplene(TM) is advancing ...
... WASHINGTON, Sept. 17 Earlier this year,President George ... Plan for AIDS Relief (PEPFAR), which is set to ... calls for an increase in funding from the,initial 2003 ... next five,years., On September 20, 2007, the Woodrow ...
Cached Medicine Technology:EpiCept Reports Regulatory Progress on Ceplene(TM) 2EpiCept Reports Regulatory Progress on Ceplene(TM) 3EpiCept Reports Regulatory Progress on Ceplene(TM) 4EpiCept Reports Regulatory Progress on Ceplene(TM) 5Director's Forum: PEPFAR and the Global AIDS Response 2
Algerbrush II corneal rust ring remover battery powered...
Katena ophthalmic burr for polishing pterygiums, includes one round diamond burr and has an storage case....
... The Marco 35-6 TW full diameter ... market leader for over twenty years. While ... throughout the manufacturing process, the Marco 35-6 ... the standard for excellence by adhering to ...
Khosla Mini Non-Illuminated Trial Lens Set, With Lenses Mounted...
Medicine Products: