Navigation Links
A new target in acute myeloid leukemia
Date:7/16/2012

Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent mutations observed in acute myeloid leukemias. FLT3 mutants are thought to activate several signaling pathways that contribute to cancer development. Dr. Daniel Tenen and colleagues from Harvard University in Boston discovered a new pathway activated by FLT3 mutation. Their results show that cyclin dependent kinase 1 (CDK1), a critical regulator of cell division is activated in FLT3 mutated leukemias, leading to the activation of downstream gene transcription. Most importantly, they demonstrate that inhibiting CDK1 activity promotes differentiation of cells from patient-derived peripheral blood samples. As clinical trials with CDK1 inhibitors are ongoing, their data strongly suggest that therapies targeting the CDK1 pathway may be efficacious for acute myeloid leukemias with FLT3 mutation, especially in patients resistant to FLT3 inhibitor therapies.


'/>"/>
Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. SMART heart eases heart ache, targets cardiac patients emotional well-being
4. Target set on cancer gene MCL1
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. IBN discovers human neural stem cells with tumor targeting ability
7. A closer look at PARP-1 reveals potential new drug targets
8. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
9. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
10. Scientists identify new target to battle rheumatoid arthritis
11. Scientists identify possible drug target for acute pancreatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... CO (PRWEB) August 22, 2014 ... provider of in-home care for seniors, is proud to ... Webinar Series. The upcoming webinar will feature Dr. Suzanne ... at Lenox Hill Hospital in New York City, National ... and author. The webinar will cover the issues surrounding ...
(Date:8/22/2014)... News) -- College can be a challenging time for young ... do to make the most of their new life, an ... meet new people and learn to manage the temptations of ... assessment at St. John,s University in New York City, said ... place in the classroom. College is a time when students ...
(Date:8/22/2014)... 22, 2014 ItsHot.com, a client-centric manufacturer, ... 60-80% off on its range of beautiful diamond heart ... of Gold Hearts 14K White Rose Gold Diamond Heart ... discount of 77%. Previously priced at $3,715.00, customers can ... item code of this mesmerizing pendant embedded with 0.66 ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 According ... Type & Application - Global Trends & Forecast ... with an analysis and forecast of the market ... to $38,729 million by 2019, at a significant ... market data tables and 44 figures spread through ...
(Date:8/22/2014)... Each year approx. 265,000 Danes are acutely admitted to ... from Aarhus University and Aarhus University Hospital now shows ... fourth patient are sent home again without receiving ... the acute hospitalisation., "Naturally, there is no need for ... that there is a serious illness. So some patients ...
Breaking Medicine News(10 mins):Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3Health News:College Prep 101 2Health News:ItsHot.com Now Offers 60-80% Discount on its Striking Collection of Diamond Heart Pendants 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 3Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 4Health News:Many patients are discharged without a diagnosis 2
... By Maureen Salamon HealthDay Reporter , WEDNESDAY, ... risk of developing breast cancer by avoiding unnecessary medical ... but they don,t need to worry about using hair ... Reviewing the body of research on environmental factors ...
... HILL, N.C. -- New research from the University of ... may help explain the failure of some recent clinical trials ... others that used the same drugs. The study published ... Medicine , also suggests how to improve the chances for ...
... The behavior of consumers who are faced with making decisions ... health messages are worded or framed, according to a large, ... other institutions., The results of the study, published today (Dec. ... contradict the premise of the framing effect on making health ...
... There is still a one in eight lifetime risk that ... against the disease remains early detection. Now, Women & infants ... to the next level with the installation of the most ... & Infants is the first and only facility in southeastern ...
... , WEDNESDAY, Dec. 7 (HealthDay News) -- Two U.S. Food ... whether to recommend new warning labels about increased risk of ... The Reproductive Health Drugs Advisory Committee and the Drug Safety ... the public, and then make a recommendation to the full ...
... that affect the levels of an important brain protein involved ... seen during aging, according to an animal study in the ... The findings could one day aid in the development of ... Aging-related memory loss is associated with the gradual deterioration of ...
Cached Medicine News:Health News:Expert Panel Pinpoints Environmental Culprits in Breast Cancer 2Health News:Expert Panel Pinpoints Environmental Culprits in Breast Cancer 3Health News:Expert Panel Pinpoints Environmental Culprits in Breast Cancer 4Health News:When prophecy fails: How to better predict success in HIV prevention clinical trials 2Health News:When prophecy fails: How to better predict success in HIV prevention clinical trials 3Health News:Behavior of people faced with health-care choices is not influenced by 'framing effect,' study finds 2Health News:Behavior of people faced with health-care choices is not influenced by 'framing effect,' study finds 3Health News:Hospital gives first tomosynthesis mammograms in region this week 2Health News:FDA Panels to Weigh Safety of Newer Forms of the 'Pill' 2Health News:FDA Panels to Weigh Safety of Newer Forms of the 'Pill' 3Health News:Drug reverses aging-associated changes in brain cells 2
(Date:8/21/2014)... , Aug. 21, 2014  eRelevance Corporation ( ... announced today that it has completed integration with ... for Plastic Surgery and Dermatology practices. ... value to healthcare practices using Nextech," stated ... Corporation. "Using information from the EMR we are ...
(Date:8/21/2014)... /CNW/ - Eisai Limited is pleased to support the Canadian ... book available in Canada . The comic ... educate children and their parents about epilepsy, the most common ... than 300,000 Canadians. Eisai is guided by a corporate philosophy ... the patient is central – there was a need within ...
(Date:8/21/2014)... /PRNewswire-iReach/ -- Inc. magazine today ranked ... straight year, No. 349 in Health on its ... the nation,s fastest-growing private companies. The list represents ... segment of the economy—America,s independent entrepreneurs. Companies such ... Zillow, and many other well-known names gained early ...
Breaking Medicine Technology:eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
... DIEGO, Jan. 10, 2011 Optimer Pharmaceuticals, Inc. (Nasdaq: ... Linda Amper, Ph.D., as Senior Vice President of Human ... Economics & Outcomes Research (HEOR), and John Womelsdorf, Ph.D., ... will strengthen the management team as the Company prepares ...
... Calif., Jan. 10, 2011 OncoMed Pharmaceuticals, Inc., ... today announced that patient dosing has commenced in a Phase ... tumor cancers.   OMP-59R5 is a monoclonal antibody ... to specifically block these targets to enter human studies.  The ...
Cached Medicine Technology:Optimer Pharmaceuticals Announces Key Additions to Management Team 2Optimer Pharmaceuticals Announces Key Additions to Management Team 3Optimer Pharmaceuticals Announces Key Additions to Management Team 4OncoMed Pharmaceuticals Initiates Phase 1 Clinical Trial of Anti-Cancer Stem Cell Therapeutic OMP-59R5 2OncoMed Pharmaceuticals Initiates Phase 1 Clinical Trial of Anti-Cancer Stem Cell Therapeutic OMP-59R5 3
0.2 mm hook with curved shaft to reach over lens optic. Flat serrated handle with polished finish. Overall length: 4.8 inches. Most popular size or model....
Angled 45 degrees, 10 mm shaft with 0.2 mm tip. Round knurled handle with dull finish. Overall length: 4.6 inches....
Straight 31 mm shaft with flat handle and polished finish. 0.5 mm cup. Overall length: 5 inches....
0.5 mm curette cup, reverse side of sandblasted to polish capsule. Round knurled handle with polished finish. Overall length: 5 inches....
Medicine Products: