Navigation Links
A new soldier in the war on cancer: The blind mole rat
Date:3/4/2009

If someone ever calls you a "dirty rat," consider it a compliment. A new discovery published online in the FASEB Journal (http://www.fasebj.org) shows that cellular mechanisms used by the blind mole rat to survive the very low oxygen environment of its subterranean niche are the same as those that tumors use to thrive deep in our tissues. The net effect of this discovery is two-fold: first the blind mole rat can serve a "living tumor" in cancer research; andperhaps more importantthat unique gene in the blind mole rat becomes a prime target for new anti-cancer drugs that can "suffocate" tumors.

"President Obama said in his February 24 address to the U.S. Congress that he wants to put an end to cancer, and the boost to basic science in the stimulus package is a great start," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "But if he wants to end the longest ongoing war in U.S. historya War on Cancer we've been fighting since before Nixon declared it in 1971then building on this discovery is a good place to start."

To reach their finding, American and Israeli scientists from the Universities of Illinois and Haifa conducted experiments in multiple groups of "dirty" mole rats and "regular" rats. For each type of animal, a control group was exposed to normal levels of oxygen while the experimental groups were exposed to oxygen levels ranging from 3 percent to 10 percent. In the regular rats exposed to low levels of oxygen, the gene that becomes active to protect their bodies from low oxygen (BNIP3) was shown to be active in heart and skeletal muscles. In the mole rats, however, it was discovered that their version of the BNIP3 gene was much more effective at helping them tolerate low levels of oxygen than the version of the gene in "regular" rats.

"In show biz and politics, people make comebacks all the time," Weissmann added, "but rodents aren't usually that lucky. Since the bubonic plague in the 1300s, the reputation of rats has been in the sink. If the blind mole rat ultimately helps us cure cancer, it will be the greatest comeback of all time in public health and in public relations."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Regional Anesthesia Eases Wounded Soldiers Pain in Iraq and Afghanistan
2. Old Tech Helps Soldiers With New Wound Infection
3. Soldiers' Angels Announces Special Wheelchair Covers for Veterans
4. LegalView Updates Brain Injury Site with Information on TBI Disabled Soldier's Family
5. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
6. LegalView Brain Injury Site Reports Department of Veteran Affairs Request for Research on TBI and Soldiers
7. National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers
8. US soldiers in high-tuberculosis areas face new epidemic: false positives
9. New Veterans Drug Court Focuses on Rehabilitating Our Soldiers Through Mental Health Treatment
10. Soldiers Receive Free Memorial Day Lasik Surgery Before Going to Iraq
11. UVA Health System part of Armed Forces multi-million dollar effort to help soldiers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... ... city where’s it’s easy to spot the neon lights of chains serving fast food, one ... a taste for real food. , On May 13, the Best Western Plus ... restaurant focusing on dishes made by hand with wholesome, organic ingredients that are sourced locally ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... annual campaign returns for a third time to shed lights on the variety of ... resources and inspirational stories, “Nurse Appreciation” tackles why this career has gone from being ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Beleza ... Army body fat composition regulations. This is the first time that Coolsculpting is ... screened at least every six months to ensure they meet the prescribed body-fat standard, ...
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after the Federal ... an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting Center at ... Committee (FOMC) dot charts are of interest to the press for their noise potential,” ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... (IP) to its specialty academic programs. , Answering to the increasing demand for ... programs in health law, and environmental and land use law. ,  , “The ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 MedDay, a ... announces that an oral presentation entitled "High doses of biotin ... trial" will be given by Professor Ayman Tourbah , ... Congress of the European Academy of Neurology (EAN) in ... related disorders 3" will take place on Sunday, 29 May ...
(Date:5/24/2016)... May 24, 2016 Niederländische ... gebracht, die es Ärzten erlaubt, ihre Expertise weltweit ... MDLinking kombiniert Live Streaming mit einer Instant-Messaging-Funktion und ... kommunizieren. Mediziner in Europa, Afrika, Asien und den ... für die Plattform registriert. Information und ...
(Date:5/24/2016)... May 24, 2016   , ... non-inferiority in overall bowel cleansing and superiority in ... leansing of the ... ) , Norgine B.V. today announced new positive data ... and ascorbate bowel preparation) versus standard 2 litre PEG with ascorbate. ...
Breaking Medicine Technology: