Navigation Links
A new significance of LVD and angiogenic MVD is identified in human primary SCRC
Date:1/16/2008

Lymphangiogenesis and angiogenesis are critical processes for tumor growth, invasion and metastasis. Angiogenesis has established its role in the development and progression of a variety of malignancies, playing a crucial role in the dissemination of the tumor cells. However, because of the lack of specificity lymphatic endothelial makers that could be used to discriminate between lymphatics and blood vessels, the definite significance of lymphangiogenesis in sporadic colorectal carcinoma (SCRC) was not very clear.

A research article to be published on January 7, 2008 in the World Journal of Gastroenterology (volume 14, issue 1) addresses this question. The research team led by Pr. Xiang Du from Cancer Hospital, Fudan University, has investigated the lymphatic vessel density (LVD) and microvessel density (MVD) in tumoral areas of 132 cases with primary SCRC. Of the 132 cases, 74 were metastatic cases and 58 non-metastatic cases, which were evaluated by immunohistochemistry, using antibodies of D2-40 and von Willebrand factor (vWF) respectively. In addition, the researchers detected them by double labeling immunohistochemistry to prove the specificity of D2-40.

One conclusion reported by the investigators is that the lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture, with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in the cases of colorectal carcinoma with metastasis than in cases without metastasis. For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC, and for each one microvessel increased, there was a 1.11-fold increase. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were both higher than LVD.

Another conclusion is that high LVD, high MVD, co-accounting of high LVD and high MVD were associated with patients' poor disease-free survival and co-accounting of LVD and MVD was an independent prognostic factor of colorectal carcinoma.

In addition, double labeling immunohistochemistry showed D2-40 immunoreactivity was specific for lymphatic vessels.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
2. Study shows blood markers can help choose best dose for antiangiogenic drugs
3. Chemical culprit in popcorn workers lung identified
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. The genes involved in rheumatoid arthritis identified
6. Justice Department to Hold Media Event to Demonstrate New Database for Matching Unidentified Remains and Missing Persons Information
7. Normal role for schizophrenia risk gene identified
8. Unique role for blood formation gene identified
9. Second pathway behind HIV-associated immune system dysfunction identified
10. Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study
11. 3 New Lung Cancer Genes Identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Consumers have taken a more active ... more emphasis on patient outcomes. ... the pharmaceutical industry have evolved beyond just providing ... are focusing on becoming more patient-oriented across their ... services that improve health. ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: