Navigation Links
A new significance of LVD and angiogenic MVD is identified in human primary SCRC
Date:1/16/2008

Lymphangiogenesis and angiogenesis are critical processes for tumor growth, invasion and metastasis. Angiogenesis has established its role in the development and progression of a variety of malignancies, playing a crucial role in the dissemination of the tumor cells. However, because of the lack of specificity lymphatic endothelial makers that could be used to discriminate between lymphatics and blood vessels, the definite significance of lymphangiogenesis in sporadic colorectal carcinoma (SCRC) was not very clear.

A research article to be published on January 7, 2008 in the World Journal of Gastroenterology (volume 14, issue 1) addresses this question. The research team led by Pr. Xiang Du from Cancer Hospital, Fudan University, has investigated the lymphatic vessel density (LVD) and microvessel density (MVD) in tumoral areas of 132 cases with primary SCRC. Of the 132 cases, 74 were metastatic cases and 58 non-metastatic cases, which were evaluated by immunohistochemistry, using antibodies of D2-40 and von Willebrand factor (vWF) respectively. In addition, the researchers detected them by double labeling immunohistochemistry to prove the specificity of D2-40.

One conclusion reported by the investigators is that the lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture, with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in the cases of colorectal carcinoma with metastasis than in cases without metastasis. For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC, and for each one microvessel increased, there was a 1.11-fold increase. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were both higher than LVD.

Another conclusion is that high LVD, high MVD, co-accounting of high LVD and high MVD were associated with patients' poor disease-free survival and co-accounting of LVD and MVD was an independent prognostic factor of colorectal carcinoma.

In addition, double labeling immunohistochemistry showed D2-40 immunoreactivity was specific for lymphatic vessels.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
2. Study shows blood markers can help choose best dose for antiangiogenic drugs
3. Chemical culprit in popcorn workers lung identified
4. High and mighty: first common height gene identified by researchers behind obesity gene finding
5. The genes involved in rheumatoid arthritis identified
6. Justice Department to Hold Media Event to Demonstrate New Database for Matching Unidentified Remains and Missing Persons Information
7. Normal role for schizophrenia risk gene identified
8. Unique role for blood formation gene identified
9. Second pathway behind HIV-associated immune system dysfunction identified
10. Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study
11. 3 New Lung Cancer Genes Identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: