Navigation Links
A new set of building blocks for simple synthesis of complex molecules
Date:8/23/2011

CHAMPAIGN, Ill. Assembling chemicals can be like putting together a puzzle. University of Illinois chemists have developed a way of fitting the pieces together to more efficiently build complex molecules, beginning with a powerful and promising antioxidant.

Led by chemistry professor Martin Burke, the team published its research on the cover of the chemistry journal Angewandte Chemie.

Burke's group is known for developing a synthesis technique called iterative cross-coupling (ICC) that uses simple, stable chemical "building blocks" sequentially joined in a repetitive reaction. With more than 75 of the building blocks available commercially, pharmaceutical companies and other laboratories use ICC to create complex small molecules that could have medicinal properties.

"There's pre-installed functionality and stereochemistry, so everything is set in the building blocks, and all you have to do is couple them together," said graduate student Seiko Fujii, the first author of the paper.

However, ICC has been limited to only molecules with one type of polarity. Now, the group has developed reverse-polarity ICC, which allows a chemist to optimize the ICC process to match the target molecules' electronic structure. The reversal in polarity enables a whole new class of building blocks, so researchers can synthesize molecules more efficiently and even construct molecules that standard ICC cannot.

For example, in the paper, the group used the new method to make synechoxanthin (pronounced sin-ecko-ZAN-thin), a molecule first isolated from bacteria in 2008 that shows great promise as an antioxidant. Studies suggest that synechoxanthin allows the bacteria that produce it to live and thrive in highly oxidative environments.

"We as humans experience a lot of oxidative stress, and it can be really deleterious to human health," said Burke, who also is affiliated with the Howard Hughes Medical Institute. "It can lea
'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Researchers building new sensor that could stop falls by elderly, before they happen
2. Building Muscle May Reduce Diabetes Risk, Study Says
3. Beef: Americas favorite protein is an essential building block
4. Key goals for building on 30 years of HIV/AIDS research
5. I can hear a building over there
6. Playing with building blocks of creativity help children with autism
7. Coming Soon: Smoke-Free Apartment Buildings?
8. With muscle-building treatment, mice live longer even as tumors grow
9. Building a bridge with cross-cultural cancer education
10. Technology for locating first responders in buildings to be showcased at national workshop
11. Scottsdale Named One of US' Greenest Cities, Green Building Permits on the Rise
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new set of building blocks for simple synthesis of complex molecules
(Date:5/23/2013)... May 23, 2013 Sika Sarnafil ... waterproofing membranes, today announced Imperial Roof Systems of Iowa ... professionalism and dedication to quality during the re-roofing of ... Systems is a Sika Sarnafil Elite contractor and one ... Roof Systems is committed to sustainable building practices and ...
(Date:5/23/2013)... Washington, DC (PRWEB) May 23, 2013 ... by JD Media Surge, LLC. Targeting members of the ... services online and attract new patients, the consulting service ... Internet marketing strategies. , The medical Internet marketing agency ... struggling to get results online. As part of the ...
(Date:5/23/2013)... Retül University , the market leader ... formation of a strategic educational partnership with Ero ... a bike industry first “Positioned for Speed” course combining ... trial, road and triathlon bike fit. , This course ... with a Retül University, F.I.S.T. or S.I.C.I fit certification. ...
(Date:5/23/2013)... Rapids, IA (PRWEB) May 23, 2013 Diversity ... Creative Corridor have an expanded understanding of diversity. The ... The survey was done from February-March of this year. 1198 ... survey as a follow up to its benchmark survey in ... top factors reported in the definition of diversity were race ...
(Date:5/23/2013)... By Dennis Thompson HealthDay Reporter , , THURSDAY, ... taken by millions to lower their cholesterol, but the ... their cardiovascular health through exercise, researchers say. A ... to make any significant fitness gains while taking a ... not on the drug but undergoing the same exercise ...
Breaking Medicine News(10 mins):Health News:Sika Sarnafil Announces Recycling Project of the Year Winner 2Health News:Healthcare Internet Marketing Consulting Services Launched by JD Media Surge 2Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 2Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 3Health News:Diversity Focus Announces Results from the 2013 Creative Corridor Community Survey 2Health News:Statins May Hamper Workout Results 2Health News:Statins May Hamper Workout Results 3
... , , WASHINGTON, Aug. 24 In response ... and Cardiovascular H ealth: A Scienti f ic State m ... journal Circulat i on, Dr. Maureen Storey, senior vice ... for t h e America n Beverage A ...
... , Proposed Medicare Cuts Will Harm Seniors, Care, Place ... Jeopardy , , Study Finds California Seniors Hit ... Calif., Aug. 24 A new American Health Care Association analysis of ... recently-enacted Medicare regulation cutting Medicare-funded nursing home care by $12 billion over ...
... RESEARCH TRIANGLE PARK, N.C., Aug. 24 GlaxoSmithKline ... of Advair Diskus(R) (fluticasone propionate and salmeterol inhalation powder) medication ... near Richmond, Virginia. Medicine in the stolen cartons could ... the legitimate supply chain and the storage conditions under which ...
... , NASHVILLE, Tenn., Aug. 24 Cumberland ... it will report second quarter 2009 financial results before the market ... live Internet webcast will be held on Thursday, August 27, 2009 ... , To participate on the call, please dial 877-604-9672 ...
... , , , - ... flawed document he says "pushes pulling the plug." , ... of the national non-profit organization Aging with Dignity, today called on ... "Your Life, Your Choices" advance care planning guide dubbed "The Death ...
... down the disease, study says , MONDAY, Aug. 24 ... very early stages of Alzheimer,s disease might become hyperactive ... , Researchers from the Cleveland Clinic tested 69 mentally ... Alzheimer,s disease because of family history or genetic markers. ...
Cached Medicine News:Health News:American Beverage Association Response to American Heart Association Statement on Added Sugars 2Health News:New Study of House Health Reform Bill: California Faces Over $3.7 Billion in Medicare-Funded Nursing Home Cuts Over Ten Years 2Health News:GSK Advisory: Warehouse Theft 2Health News:Cumberland Pharmaceuticals to Announce Second Quarter 2009 Financial Results on August 27, 2009 2Health News:Veterans Administration Must Suspend Use of So-Called 'Death Book' on Veterans, Malley Says 2Health News:MRI Might Find Early Alzheimer's 2
(Date:5/23/2013)... TARRYTOWN, N.Y. , May 23, 2013 /PRNewswire/ ... reconstruction following mastectomy is an appropriate option ... mutations seeking to surgically reduce their breast cancer ... involves a gradual expansion process and a second ... of implants in the same surgery as mastectomy ...
(Date:5/23/2013)... -- Net Medical Xpress Solutions, Inc., (OTC QB: NMXS), a ... has signed a letter of intent to acquire MedTel ... Huntsville, AL . MedTel Solutions is a physician ... of telemedicine physicians. Consideration for the acquisition will be ... expected by June 30, 2013. Dick Govatski, ...
(Date:5/23/2013)... AVIV, Israel , May 23, 2013 ... BrainTech Israel 2013 , Israel,s ... place on October 14 th -15 th in ... nd most innovative city in the world by the ... "Start-up Nation." BrainTech Israel 2013 will showcase the ...
Breaking Medicine Technology:Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 2Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 3Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 2Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 3
... Stem Cell Sciences From University of Cambridge ... - ("Stem Cell Sciences", "SCS", "the Company"), ... STEM, ASX: STC), a company focused on the commercialisation ... paper describing a technique,for reprogramming adult mammalian cells into ...
... Sourced from China Shows Strong Results Presented at ... Cambridge Healthtech Institute Fall Conference, BOSTON, ... Bioscience International (HUYA) today described the,preclinical profile and outcome ... China by Chipscreen Biosciences, Ltd. of Shenzhen. The,clinical trial ...
Cached Medicine Technology:Technique for Rapidly Reprogramming Adult Cells Into Stem Cells Published in PLoS Biology 2Technique for Rapidly Reprogramming Adult Cells Into Stem Cells Published in PLoS Biology 3Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer 2Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer 3Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer 4Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer 5
... the Marco Keratometer I and ... instruments for objectively measuring corneal ... the added feature of internal ... or those who prefer to ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
Medicine Products: