Navigation Links
A new screening method for prostate cancer
Date:2/2/2012

A new study by NYU Langone Medical Center and Northwestern University Feinberg School of Medicine shows novel PSA velocity (PSAV) risk count testing may provide a more effective way for physicians to screen men for clinically significant prostate cancer. The new study, published online by the British Journal of Urology International on February 1, 2012, shows the benefits of tracking a man's PSA levels over time to help doctors more accurately assess his risk of life-threatening prostate cancer.

"Risk count could represent a new way to screen for prostate cancer by focusing on men with the greatest risk of harmful prostate cancers," said lead author Stacy Loeb, MD, an urologist in the Department of Urology and the Joel E. Smilow Comprehensive Prostate Cancer Center at NYU Langone. "The goal of risk count is to help identify the aggressive, clinically significant prostate cancers before advanced symptoms develop, while decreasing the diagnosis of insignificant cancers."

Prostate cancer is the second leading cause of cancer death in American men, with an estimated 1 in 6 men diagnosed with the disease during their lifetime. Prostate cancer does not present symptoms until advanced stages so screening for the disease is vital. Currently, a PSA blood test is the standard screening method to evaluate a man's risk of prostate cancer. It measures the amount of prostate-specific antigen in the blood, a substance made only in the prostate gland. An elevated PSA can indicate the presence of disease. However, PSA can also be elevated with benign prostate enlargement and one high PSA value does not always mean an aggressive prostate cancer is present.

The new PSAV risk count screening works by monitoring fluctuations in PSA levels over time to analyze a man's risk of prostate cancer, instead of relying on just one PSA test result to assign prostate cancer risk. The risk count is calculated by counting the number of times in a row that the PSA level in the blood increases by 0.4 ng/mL. If PSA goes up by more than 0.4 units multiple years in a row, the risk count rises indicating the patient has an increased risk of aggressive prostate cancer. For example, a man who has a PSA screening for two years in a row would be given a "2" risk count if his serial PSA velocity measurements increased by more than 0.4 units, a "1" risk count if there was only one increase by more than 0.4 units, and a "0" risk count if there was no increase by more than 0.4 units.

In the study, researchers showed PSAV risk count could improve the specificity of screening for prostate cancer and advanced stages of the disease. Researchers evaluated 18, 214 men undergoing prostate cancer screening, 1,125 of which were diagnosed with the disease. The study results show sustained rises in PSA levels over time indicate a significantly greater risk of prostate cancer and more aggressive disease. In the study, a risk count of "2" was associated with a greater than 8-times risk of prostate cancer and a 5-fold greater risk of aggressive disease. The authors conclude risk count screening may be useful in diagnosing aggressive prostate cancer earlier while possibly reducing unnecessary biopsy, as well as the overdiagnosis and resulting overtreatment of low-risk prostate cancer.

"A persistently rising PSA is a harbinger for life-threatening prostate cancer," said the study's senior author, William Catalona, MD, professor of Urology at Northwestern University. "Our study findings show looking at how much PSA changes over time helps distinguish which cancers are aggressive more so than a single PSA value."

In an accompanying editorial, Dr. H. Ballentine Carter from the Brady Urological Institute at Johns Hopkins who initially suggested the concept of looking at PSA changes over time, affirms that in order to determine the likelihood of aggressive prostate cancer, "you want to know your patient's risk count, not just their age and PSA level."


'/>"/>
Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. Women not following through with recommended breast screening MRI
2. Prostate cancer screening and treatment decisions must act on evidence, not beliefs
3. HPV testing: Indications of a benefit in primary screening
4. Neuropathy patients more likely to receive high-cost, screening instead of more effective tests
5. Newborn screening program aims to help transform treatments for genetic diseases detected at birth
6. Obesity and cancer screening: Do race and gender also play a role?
7. Study shows no evidence of a mortality benefit to PSA screening
8. Mass prostate cancer screening doesnt reduce deaths
9. New drug screening identifies chemical agents with potent anti-cancer activity
10. Self-affirmation may break down resistance to medical screening
11. Screening Alone Not Enough to Prevent Sudden Death in College Athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... ... awareness and author of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics ... 2, 2016 and podcasted thereafter . Dr. Bernie Siegel, author of a ...
(Date:4/29/2016)... ... April 29, 2016 , ... Spine Team Texas, a comprehensive ... to announce one of their physicians has been invited to be a featured speaker ... Family Practice Review conference on April 30, 2016. , Dr. R. Scott McPherson, ...
(Date:4/29/2016)... , ... April 29, 2016 , ... Melanoma is the deadliest type of skin cancer. ... for the majority of skin cancer deaths. More than 10,000 people are expected to die ... diagnosis is 62, it is the one of the most commonly diagnosed cancers in young ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the market leader in ... by Eastside Partners, with participation from existing investor Martin Ventures. The funds ... its technology and product roadmap. , “Jvion is experiencing significant growth ...
(Date:4/29/2016)... ... 29, 2016 , ... Nike Softball Camp at the College of Brockport in ... for girls aged 10-18. All facets of the game will be covered; hitting, fielding, ... Complex, one of the finest softball facilities in the region. The outstanding professional college ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... TapImmune,Inc. (TPIV), a clinical-stage immune-oncology company ... and vaccines for the treatment of cancer & metastatic disease, ... Growth Capital Expo to be held on May 3 ... in Las Vegas, Nevada.  The Company presentation will be ... by Dr. John N. Bonfiglio a TapImmune Board ...
(Date:4/27/2016)... 27, 2016   ... in Recurring Consumable Sales  Clinical sales grow ... Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the ... for the first quarter ended March 31, 2016 and ... of its commercial strategy. First Quarter 2016 ...
(Date:4/27/2016)... April 27, 2016  Bayer Animal Health today ... from the University of Florida College of Veterinary ... Excellence in Communication Award (BECA). Brittany was selected ... awarded a total of $70,000 in scholarship funds ... years, Bayer has provided a total of $232,500 ...
Breaking Medicine Technology: