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A new route for tackling treatment-resistant prostate cancer
Date:7/24/2012

at the Medical Center and a world-renowned expert in the diagnosis and treatment of prostate cancer, says "This is a potentially important observation since, as of now, most cancers eventually escape available means of inactivating androgens and their receptor. If paxillin proves to be a major new pathway, interfering with it may extend life or even cure men with far advanced prostate cancer, a stage of the disease which until now has always proved lethal."

The team conducted multiple tests to confirm the power of paxillin in prostate cancer. They found that paxillin is ramped up in tissue from human tumors, much more so than in normal cells. And in mice with human prostate cancer cells, getting rid of paxillin caused the tumors to grow more slowly.

Hammes says the next step is to figure out how to stop paxillin from getting into the nucleus, or to inhibit its activity once it's in the nucleus. "Paxillin has important functions in the cytoplasm, like helping cells communicate with each other to form organs and other structures," he noted. "If we can target paxillin in the nucleus where it mediates cancer cell growth, but leave it intact in the cytoplasm so it can continue to do the important work it does there, that would be the goal."

Like any targeted cancer therapy, the team wants to hurt the cells that are proliferating, and leave the healthy cells that are standing still alone, says Hammes.


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Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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