Navigation Links
A new route for tackling treatment-resistant prostate cancer
Date:7/24/2012

Scientists have identified what may be the Peyton Manning of prostate cancer. It's a protein that's essential for the disease to execute its game plan: Grow and spread throughout the body.

Like any good quarterback, this protein has command over the entire field; not only does it control cell growth in tumors that are sensitive to hormone therapy, a common treatment for men with advanced disease, but also in tumors that grow resistant to such treatment a dismal development that leaves men and their doctors with no good options to turn to.

In a study published in the Journal of Clinical Investigation, a team led by scientists from the University of Rochester Medical Center found that the protein paxillin is a major player in prostate cancer, the second most common form of cancer in men. Though in the very early stages, the discovery is an important first step towards developing a treatment for men whose cancer prevails even after the most aggressive treatment.

"The holy grail in prostate cancer is to figure out why cells stop responding to hormone therapy," said senior study author Stephen R. Hammes, M.D., Ph.D., chief of the Division of Endocrinology and Metabolism at the Medical Center. Initially, hormone therapy, which starves tumors of the hormones that fuel their growth, works well and may lead to remission. But, according to the American Cancer Society, nearly all prostate cancers treated with hormone therapy become resistant over a period of months or years and the cancer makes an unwelcome comeback.

"Somehow, tumors find a way to grow even when their main power source is choked off," noted Hammes, also the Louis S. Wolk Distinguished Professor in Medicine. "Our work is exciting because we've identified a protein pathway that controls growth even in the absence of hormones and provides a completely new treatment target for the disease."

Hammes and first author Aritro Sen, Ph.D., Research Assistant
'/>"/>

Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
3. New roadmap suggests proven routes to ending health disparities
4. New drug prevents spread of human prostate cancer cells
5. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
6. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
7. Study examines adverse effects among different radiation therapies for prostate cancer
8. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
9. Warren Buffett Has Early Stage Prostate Cancer
10. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
11. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/14/2014)... (PRWEB) September 14, 2014 Globally the ... America, mainly in the US, followed by Europe and ... therapy centers and many are in development phase or ... in different countries as various governments are showing interest ... in Europe, mainly because of low awareness of this ...
(Date:9/14/2014)... Columbus, OH (PRWEB) September 14, 2014 A ... Wright & Schulte LLC on behalf of a Franklin ... DePuy metal-on-metal hip implant. The metal-on-metal hip lawsuit filed ... states that the Ohio man was 40 years old when ... hip. (Case No. 3:14-cv-02428-K) According to the hip ...
(Date:9/13/2014)... Over the past five years, ... Australia have shown signs of struggle. “The ... goods has caused Australian consumers to turn away ... IBISWorld industry analyst Ryan Lin. This trend has ... health consciousness, which has alerted the Australian population ...
(Date:9/13/2014)... MillionaireSinglesDating.com is a millionaire dating site ... dating services provider, which also launched the leading ... daddy site , SugarDaddyMeet.com, and the leading ... recently reached 2 million users milestone. , MillionaireSinglesDating.com ... include CEOs, lawyers, doctors, pro athletes, models and ...
(Date:9/13/2014)... September 13, 2014 Bedros Keuilian, founder of ... fitness marketing coach , has always been an advocate of ... most useful days are over, but the post explains that ... need to change. , “A lot of people think of ... says Keuilian. “They run a special and the only thing ...
Breaking Medicine News(10 mins):Health News:Global Proton Therapy Market Trends and 2018 Opportunities Now Available at MarketReportsOnline.com 2Health News:Global Proton Therapy Market Trends and 2018 Opportunities Now Available at MarketReportsOnline.com 3Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 2Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 3Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 4Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 5Health News:Confectionery Manufacturing in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Confectionery Manufacturing in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:MillionaireSinglesDating.com Reaches 2 Million Users Milestone 2Health News:Renegade Fitness Marketing Expert Reveals How Personal Trainers Can Use Groupon More Effectively to Sign New Clients 2Health News:Renegade Fitness Marketing Expert Reveals How Personal Trainers Can Use Groupon More Effectively to Sign New Clients 3
... for Research in Vision and Ophthalmology is honored to ... of ARVO Fellow recognizes members for their accomplishments, leadership ... this honor, ARVO anticipates that Fellows will continue to ... careers in vision and ophthalmology research and to further ...
... ... concerned with the pathogenesis of disease at the molecular level, in order to design ... ... time a person experiences symptoms of an aggressive brain tumor it is often too ...
... ALS ( Lou Gehrig,s disease) named Service Related Disorder Earlier ... In recognition of multiple studies connecting ALS to military ... December 22, 2009 , provided for the grant of ... Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig,s disease).  Deemed a ...
... , , DETROIT , ... today announced that its Board of Directors has set the date for ... for shareholders eligible to vote at the meeting.   , The Annual ... at 10:30 am EST at the MGM Grand Hotel, 1777 ...
... cuts that risk significantly, study finds , TUESDAY, Jan. 12 ... increase in resting heart rate boosts the risk of dying ... has found. , Norwegian researchers tracked the health of about ... of 18 years. During that time, 6,033 men and 4,442 ...
... Frank conversations about hospice and preferred place of death are ... -- Terminally ill patients have much to consider, from whether ... to whether they want doctors to continue aggressive treatment or ... months. , Yet those difficult, emotional conversations aren,t happening nearly ...
Cached Medicine News:Health News:ARVO announces 2010 fellows 2Health News:ARVO announces 2010 fellows 3Health News:ARVO announces 2010 fellows 4Health News:News from the Latest Issue of Molecular Medicine 2Health News:ALS Therapy Development Institute Receives $1.6 Million Grant From the Department of Defense for Lou Gehrig's Disease Research 2Health News:ALS Therapy Development Institute Receives $1.6 Million Grant From the Department of Defense for Lou Gehrig's Disease Research 3Health News:ALS Therapy Development Institute Receives $1.6 Million Grant From the Department of Defense for Lou Gehrig's Disease Research 4Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 3Health News:Faster Heart Rate May Raise Risk of Heart Attack Death 2Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 2Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 3
(Date:9/12/2014)... DALLAS , September 12, 2014 ... Cans Market by Application [Beverages (Alcoholic, CSD, Sports & ... Food, Pet Food, Meat & Seafood)], by Material ... published by MarketsandMarkets, defines and segments the Food ... projections of each application in terms of volumes ...
(Date:9/12/2014)... , Sept. 12, 2014  Royal Philips (NYSE: ... number of innovations at ASTRO,s 56th Annual Meeting ... solutions that increase workflow automation, confidence, consistency and accuracy ... and enhancing patient-centric care, these radiation oncology solutions underscore ... a more personalized approach to medicine. "Philips ...
(Date:9/12/2014)... DUBLIN , Sept. 12, 2014 Research ... Cancer Screening (Mammography, MRI & Ultrasound) Market & Forecast - ... cancer is the most common cancer among women in both ... was in double digit Billion US$ for 2013. ... cancer screening globally. China is expected ...
Breaking Medicine Technology:Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 2Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 3Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 4Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 2Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 3Breast Cancer Screening (Mammography, MRI & Ultrasound) Market & Forecast - Worldwide 2Breast Cancer Screening (Mammography, MRI & Ultrasound) Market & Forecast - Worldwide 3Breast Cancer Screening (Mammography, MRI & Ultrasound) Market & Forecast - Worldwide 4
... March 7, 2011 Ajinomoto Co., a leader ... safe, effective nutraceutical solutions, has announced that its ... federal trademark registration, (®), on the Principal Register ...  The trademark is the latest milestone for Capsiate ...
... 7, 2011 HGI Global Holdings, Inc., a leading ... today announced the appointment of Michael B. Petras, Jr. ... Mr. Petras, 43, joins HGI from GE Lighting, ... (NYSE: GE ) where he served as ...
Cached Medicine Technology:Ajinomoto Co.'s Capsiate Natura® Reaches New Milestone 2Michael Petras, Former CEO of GE Lighting, Named CEO of Cleveland-Based Specialty Medical Supplies Leader 2Michael Petras, Former CEO of GE Lighting, Named CEO of Cleveland-Based Specialty Medical Supplies Leader 3
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... incorporate a layered design unique in the ... to prevent stray electrosurgical burns along the ... failure or capacitive coupling; a well-documented patient ... all AEM Instruments provides a neutral return ...
... incorporate a layered design unique in the ... to prevent stray electrosurgical burns along the ... failure or capacitive coupling; a well-documented patient ... all AEM Instruments provides a neutral return ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
Medicine Products: