Navigation Links
A new program for neural stem cells

This release is available in German.

Neural stem cells can do a lot, but not everything. For example, brain and spinal cord cells are not usually generated by neural stem cells of the peripheral nervous system, and it is not possible to produce cells of the peripheral nervous system from the stem cells of the brain. However, researchers from the Max Planck Institute for Brain Research in Frankfurt and the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded in producing central nervous system cells from neural stem cells of the peripheral nervous system. They found that if peripheral stem cells are maintained under defined growth conditions, they generate oligodendrocytes, which form the myelin layer that surrounds the neurons found in the brain and spinal cord.

The mammalian nervous system consists of a central (brain, spinal cord) and peripheral nervous system (e.g. nerves and sensory ganglia). Although the two systems are very closely interlinked, they differ anatomically and consist of different cell types. The cell types of the peripheral nervous system originate from precursor cells in the embryo called the neural crest. To date, it was believed that these neural crest stem cells could generate the neurons and support cells, known as glial cells, of the peripheral nervous system, but not the cells of the central nervous system.

Environmental conditions clearly determine the kind of cells into which the neural crest stem cells develop. Together with colleagues from Paris, the Freiburg- and Frankfurt-based scientists succeeded in demonstrating that, under modified conditions, these stem cells can also generate cells of the central nervous system. They exposed stem cells from the peripheral nervous system of embryonic or postnatal mice to different culture conditions. In addition to neurons, the neural crest stem cells also developed into different types of glial cells of the central nervous system, including oligodendrocytes and astrocytes. "The culture medium reprograms the neural crest stem cells in such a way that they change their identity. This worked without genetic modification of the cells," explains Hermann Rohrer from the Max Planck Institute for Brain Research.

Factors in the culture medium clearly activated a different genetic program so that cell types developed from the stem cells, which normally would not. The scientists do not yet understand the precise factors at work here. However, there are some indications that fibroblast growth factor (FGF) is involved in this transformation.

In the brains of mice at different developmental stages, the reprogrammed stem cells mainly developed into oligodendrocytes, which form the myelin layer around the neurons of the central nervous system and are, therefore, indispensable for the transmission of electrical stimuli. Transplantation experiments carried out by the researchers on genetically modified mice that do not produce myelin and have severe neurological defects proved that the new oligodendrocytes can also assume this task. "The reprogrammed stem cells can form cells of the central nervous system, and the new cells can permanently integrate into this system," says Verdon Taylor of the Max Planck Institute of Immunobiology and Epigenetics.

It is not yet clear, to what extent these basic research findings will contribute to the development of cell therapy for humans. This would require that similar stem cells are present and accessible in the peripheral nervous system of humans, and that these can be propagated and reprogrammed in culture. "At present, we only know that these stem cells in mice also have the potential to produce oligodendrocytes," says Hermann Rohrer. The scientists would now like to investigate in greater detail which molecular mechanisms are responsible for the reprogramming of the stem cells, whether neural crest stem cells also exist in the peripheral nervous system of adult mice and what kind of conditions are required to enable the reprogramming of these cells.


Contact: Professor Hermann Rohrer

Related medicine news :

1. Time to Get Focused at Exploration Summer Programs
2. Medical Training School, Pima Medical Institute Offering First Bachelor's Degree Program
3. TV drama can be more persuasive than news program, study finds
4. MSU launches first anti-counterfeiting research program
5. California IVF Discount/Rebate Program Eases Risk for Older Mothers
6. CVS/pharmacy Begins Free Health Screenings in Communities Nationwide Through A Su Salud Program
7. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
8. Planned Parenthood Sex Ed Program Is an Assault on Parental Rights
9. Red Cross Raises More Than $32 Million Via Mobile Giving Program
10. New Launches to Promote World-Class Tennis Programs at Sea Colony
11. Giant Eagle Pharmacy Free Antibiotics Program Surpasses $3 Million in Free Prescriptions
Post Your Comments:
Related Image:
A new program for neural stem cells 
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... 2017 , ... On Saturday, October 21, the Health & Wellness Center at ... raise money for the American Heart Association Heart Walk. Teams of up to 10 ... to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
Breaking Medicine Technology: