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A new molecular mechanism in breast cancer development
Date:11/15/2011

ncreased or decreased. " The researchers initially discovered the effect of HMMR by genetic analysis of affected families. Then they went on to analyse the roles of these genes in breast cells and their effects when mutated or functionally perturbed. They found that RHAMM and BRCA1 interact with proteins known to control key aspects of cell polarity and the cell division cycle, perhaps explaining why certain types of breast cancer have characteristic cell morphology and cell proliferation characteristics.

The investigation of these genetic variants is directed towards developing more accurate genetic models that can predict the risk of cancer in women who carry BRCA1 or BRCA2 mutations, and thus to help them to take appropriate preventive measures. Variants are also associated with different types of tumors, with important implications for patient prognosis.


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Contact: Bryan Ghosh
bghosh@plos.org
44-122-344-2837
Public Library of Science
Source:Eurekalert

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