Navigation Links
A new molecular mechanism in breast cancer development
Date:11/15/2011

About 10% of breast cancers are due to mutations in genes called BRCA1 and BRCA2. However, the molecular mechanism by which alteration of these genes greatly increases the risk of cancer is not fully understood. In a new study, published Nov. 15 in the online, open-access journal PLoS Biology, an international team led by Miquel ngel Pujana, of Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO), and Christopher Maxwell, now at the Child and Family Research Institute, has made an important step towards revealing the underlying pathways.

The researchers found a key interaction between BRCA1 and another protein called RHAMM (encoded by the HMMR gene). These two proteins act on a previously unknown molecular mechanism that regulates epithelial cell polarity. The researchers have shown that BRCA1 and RHAMM control the normal development of breast epithelial cells. If one or both of these genes have mutations, then the normal architecture and development of breast cells is altered in ways that increase the risk of a specific tumor type appearing.

"BRCA1 mutation carriers are at high risk for breast cancer," said Pujana, "but these mutations exhibit variable penetrance, which can be in part explained by other genetic factors such as the identified variant in HMMR." A common genetic variant of HMMR slightly increases (approximately 1.1-fold) the risk of breast cancer in women carrying BRCA1 mutations. "Therefore, by itself, this variant does not justify a genetic analysis," explains Pujana.

But as shown by other CIMBA (Consortium of Investigators of Modifiers of BRCA1 and BRCA2) investigators, if other mutations are added which also slightly modify the risk -- and about twenty are known now -- then "it may vary considerably the risk of developing breast cancer in these women. Depending on the combination of genetic modifier variants that are inherited, the risk of developing cancer might be i
'/>"/>

Contact: Bryan Ghosh
bghosh@plos.org
44-122-344-2837
Public Library of Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. The Association for Molecular Pathology celebrates ruling in DNA patent case
5. USC researchers discover new molecular subtype of brain cancer
6. Molecular discovery points to new therapies for brain tumors
7. Molecular marker could help spot pancreatic cancer early
8. News from Molecular Medicine
9. Scientists discover the molecular heart of collective behavior
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. Acupunctures molecular effects pinned down
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a comprehensive high-tech ... marketing of a series of induction heating equipment. Today, ... of induction brazing equipments . , According to ... refers to the joining of two or more ... manager says that there are fundamental differences in the ...
(Date:12/25/2014)... 26, 2014 The microscopy market ... 7.2% to reach $5,756.0 million by 2019. Optical ... market. The electron microscopes product segment is expected ... period. , Rising focus on nanotechnology, technological advancements, ... the microscopy market. , Get Full Copy of ...
(Date:12/25/2014)... The click strand woven bamboo flooring ... the business announces a click strand woven bamboo ... 2015. , Click strand woven bamboo flooring replicates ... well-known brand in the bamboo industry. It promises ... bamboo flooring supplier. , “We are happy to ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 The ... to 2023” focuses on the current treatment landscape, unmet ... cancer market. TS-1 is an anti-cancer drug which is ... orally and is also used for treating gastric cancer ... and otastat potassium. The drug was first approved in ...
(Date:12/25/2014)... December 26, 2014 “Every three months the ... changes. A-line sweetheart evening dress will be one of the ... manager of Yunx.co.uk says. Today, the company releases 26 A-line ... up to 80% off. , “We are trying our ... style with our latest designs. Along with affordable prices, we ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3
... made available on the World Wide Web - a database ... the body. // ,The researchers had earlier identified flaws ... of cells called cilia as such a common link. They ... links associated with the tiny, hair-like cilia and implications for ...
... and the Raigmore in Inverness do not maintain hygiene standards, ... ,The study categorized hospitals by traffic light with ... set standards, amber for hospitals in the 70% and 90% ... the rate was 84.1%, while Raigmore scored 83.1% and the ...
... Pune declared Tuesday there is no Hantavirus in the flood ... Gujarat.// ,Additional director of NIV, M.S. Chaddha said: ... even a single sample contained Hantavirus." ,The medical ... two persons had died last week. Dipak Tarsariya (24) and ...
... exposed to lead on the job are 50 percent more ... not// exposed. The study author Edwin van Wijngaarden, ... risk factors such as lead must be explored. The ... a lead-cancer link, was based on the information from the ...
... held recently in Toronto. Around 24,000 scientists and activists ... that development of poor countries relies on the programs ... in the rich countries. ,Around 5 years back, ... people in poor countries who were infected with HIV ...
... doctors were stranded for days at the Charity Hospital, when ... of the storm, Charles Gibson reports from that hospital. ... might think you're in a warehouse or some kind of ... ,Charity Hospital served the poor and uninsured people ...
Cached Medicine News:Health News:John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases 2Health News:John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases 3Health News:People Exposed To Lead Likely To Die From Brain Cancer 2Health News:Fighting AIDS – a joint venture of the rich and the poor 2
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... addition of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses ... in the United States . Reimbursement ... studied. Thorough product analyses for more than 73 SMBG ...
(Date:12/22/2014)... 2014  ConvaTec, a privately-held medical products and technologies ... Interim Chief Executive Officer of the company, effective December ... Berger .  "The Board of Directors of ConvaTec thanks ... the past three years," said Magnus Lundberg , ... confident that the company is well positioned for the ...
(Date:12/22/2014)... Mass , Dec. 22, 2014 /PRNewswire/ -- RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today issued the following open letter ... Cauwenbergh , Dr. Med. Sc. Dear ... days a number of inaccurate statements posted on ...
Breaking Medicine Technology:US Self-monitoring Blood Glucose Market 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... (NYSE: DHR ) announced that Executive Vice President ... at the Goldman Sachs Global Industrials Conference in New York, ... The company also announced that President and Chief Executive Officer, ... W. Baird Industrial Conference in Chicago, Illinois on Tuesday, November ...
... (Nasdaq: ITMN ) today announced results from ... September 30, 2010.  InterMune also highlighted its recent clinical ... financial guidance for 2010.   Dan Welch, ... "Earlier this month we announced the sale of our ...
Cached Medicine Technology:InterMune Reports Third Quarter 2010 Financial Results 2InterMune Reports Third Quarter 2010 Financial Results 3InterMune Reports Third Quarter 2010 Financial Results 4InterMune Reports Third Quarter 2010 Financial Results 5InterMune Reports Third Quarter 2010 Financial Results 6InterMune Reports Third Quarter 2010 Financial Results 7InterMune Reports Third Quarter 2010 Financial Results 8
Straight crisscross serrated tips. Flat handle with holes and polished finish....
0.5 mm, 1 x 2 teeth set at 45 degrees. Serrated handle with polished finish....
Serrated handle with 7 mm tying platform and polished finish. Teeth: 0.25 mm, 2 x 2 set at 45 degrees....
1 x 2 teeth and 5.5 mm tying platform. Round knurled handle with polished finish. Teeth: 0.3 mm....
Medicine Products: