Navigation Links
A new method for clicking molecules together
Date:7/22/2013

Thiols are sulfur-containing molecules found in most proteins of the human body. Characterized by their 'garlicky' smell, they also give coffee, sweat and the spray of skunks their unique odor. Because they are so widespread in biology, medicine and materials science, thiols are ideal targets for connecting molecules like drugs or polymers together, except that they must first be fitted with a chemical group that acts like an adaptor to other molecules. One of the most potentially useful of these 'adaptors' are the alkynes, which can be extremely powerful in bioconjugation. The problem is that adding alkynes to thiols ('alkynylation') has been too difficult to be of any use outside the lab. But now, in a patent-pending publication in the Journal of the American Chemical Society, EPFL scientists have found a way to make the connection in five minutes and at room temperature, paving the way to commercial, medical and perhaps industrial applications.

Thiol alkynylation is part of 'modular' or 'click' chemistry, a field that has far-reaching applications in drug discovery, nanotechnology and bioengineering. The idea is to synthesize large molecules by quickly "clicking together" smaller ones, allowing us to change previously-inaccessible complex molecules. Although relatively new, click chemistry is actually inspired by natural processes. For example, after being synthesized in the cell, proteins are further modified with carbohydrates and lipids to change their properties. This process, known as post-translational modification, involves a whole host of complex enzymes that can be sidestepped in the lab by using click chemistry methods.

In order to achieve alkynylation, researchers from the group of Jerme Waser at EPFL used an alkyne-transfer reagent called TIPS-ethynyl-benziodoxolone (TIPS-EBX), which they have made commercially available by collaborating with Sigma-Aldrich. The EPFL researchers had found that previous alkynylation reactio
'/>"/>

Contact: Nik Papageorgiou
n.papageorgiou@epfl.ch
41-216-933-2105
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Truth about Cellulite: Naked Beauty/SYMULAST Method Review Exposes Joey Atlas' Secrets
2. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New hCG Diet Plans, a Fool-Proof Fast Weight Loss Method to Naturally Trim the Waistline
3. Electronic data methods for health care research -- update from the EDM forum
4. Researchers find 2 new methods to determine ALK status
5. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
6. JMS Enterprises Offers Manufacturer Recommended Cleaning Methods to Keep Carpets Brand New
7. The Jump Manual Review: Reveals Hiller’s Method of Vertical Jump Training
8. Cancer Survivor Linda Christina Beauregard Writes New Tell-All Book About Her Alternative Treatment Method
9. Joey Atlas’ Naked Beauty: The Symulast Method Reviewed and Secrets Exposed By Daily Gossip Magazine
10. New method successfully scores joint damage in rheumatoid arthritis
11. Water Researcher Sharon Kleyne Reports Best Methods to Reduce Summer Garden Watering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... Good Shepherd Children’s Home announces 53rd year of caring for ... Christian-based home, the children learn biblical principles and are taught ... their life. , A day in the life… , ... children begin to awake and prepare for the day ahead. ... Sleepily, she crawls out of bed and scrambles to ...
(Date:3/30/2015)... 30, 2015 GoHooper.com announces new website ... providing medical care to infants, children and adolescents and ... children. , The owner/provider Mark Hughes, MD, FAAP ... strive to provide expertise in the extensive range of ... care from health professionals who meet the medical field's ...
(Date:3/30/2015)... (PRWEB) March 30, 2015 Health Fitness Revolution, ... Trainer in the World Samir Becic, has created a new ... 2015 , which recognizes the world’s fittest leaders in terms ... first and only list of its kind to detail the ... ministers. , Among the world leaders profiled on the list ...
(Date:3/30/2015)... Columbus, OH (PRWEB) March 30, 2015 ... in product liability lawsuits, notes that the number of ... federal multidistrict litigation underway in U.S. District Court, District ... established in December 2014. "According to an update released ... on March 16th, at least 493 Syngenta lawsuits are ...
(Date:3/30/2015)... March 30, 2015 The partners of ... the grand opening of the Bella Diosa Laser Med ... the finest in laser med spa treatments. , February ... Spa and the partnership bridges the medical services provided ... treatments provided by Bella Diosa for both women and ...
Breaking Medicine News(10 mins):Health News:Good Shepherd Children’s Home Announces 53rd Year of Providing a Safe-Haven for Children in Need 2Health News:Nashville Web Design Company Announces New Site Launch For Pediatrics Doctor 2Health News:The Top 13 Fittest Heads of State: Why Putin Might Be No. 1 in Health and Fitness 2Health News:Syngenta Corn Lawsuit Claims Continue To Be Filed By Non GMO Corn Farmers Reports Wright & Schulte LLC 2Health News:Syngenta Corn Lawsuit Claims Continue To Be Filed By Non GMO Corn Farmers Reports Wright & Schulte LLC 3Health News:Yonkers Celebrates the Grand Opening of Bella Diosa 2
... ... set…GO! Summer kicks off each year with the City of Laguna ... year, the event is expected to bring out more than 6,000 runners, ... Day – Monday May 31. Registration is available online at www.lagunahillshalfmarathon.com ...
... , ... its place as one of the world,s leading medical hubs as it performs an ... and debilitating condition. , ... Singapore (PRWEB), May 6, 2010 -- Singapore,s oldest and largest tertiary acute hospital ...
... imaging (MRI) should be the imaging modality of choice for ... spread beyond the breast) as it is highly accurate and ... (shows no symptoms), according to a study to be presented ... Whole body MRI is a noninvasive medical test that ...
... Results from the SPIRIT IV clinical trial, which were ... scientific symposium, were published today in the New ... trial, a large-scale multi-center study of nearly 4,000 patients ... safety and efficacy in the treatment of de novo ...
... ... questions in the "By the Way, Doctor" feature. The newsletter,s May 2010 issue answers 13 ... Boston ... Letter offers answers to readers, serious, whimsical, and just plain curious questions ranging from ...
... discovered that the ovarian hormone progesterone plays a pivotal ... has important implications for breast cancer risk. ... (10.1038/nature09091; http://dx.doi.org/ ), are significant because reproductive history ... says principal investigator Rama Khokha, a molecular biologist at ...
Cached Medicine News:Health News:City of Laguna Hills Announces Memorial Day Half Marathon and 5K 2Health News:Singapore Performs Asia's First Combined Heart and Liver Transplant 2Health News:Singapore Performs Asia's First Combined Heart and Liver Transplant 3Health News:Singapore Performs Asia's First Combined Heart and Liver Transplant 4Health News:Singapore Performs Asia's First Combined Heart and Liver Transplant 5Health News:Whole body MRI is highly accurate in the early detection of breast cancer metastases 2Health News:Study finds everolimus-eluting stent safer, more effective than paclitaxel-eluting stent 2Health News:Harvard Health Letter Features Q&As from Harvard Doctors 2Health News:PMH cancer researchers link ovarian hormone to breast stem cells growth 2
(Date:3/30/2015)...  Orexigen Therapeutics, Inc. (Nasdaq: OREX ) ... joined as Chief Commercial Officer. As the Company ... HCl / bupropion HCl extended release), Cannell will ... assuming responsibilities previously held by Mark Booth ... the U.S. launch of Contrave, Booth plans to ...
(Date:3/30/2015)... , March 30, 2015  Edison Nation Medical, ... worldwide search for product innovations to assist seniors ... ideas uncovered during the 8-week search will be ... commercialization.  Invention ideas can be submitted through a ... through May 28, 2015. The objective ...
(Date:3/30/2015)... , March 30, 2015   CSL Behring ... (EMA) has started the Centralized Procedure for reviewing ... long-acting fusion protein linking recombinant coagulation factor IX ... rIX-FP will provide hemophilia B patients in the ... Economic Area (EEA) countries, with a long-acting treatment ...
Breaking Medicine Technology:Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 2Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 3Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 4Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 5Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 6Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 7Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 8Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 9Orexigen Therapeutics Announces that Tom Cannell has Joined As Chief Commercial Officer 10Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 2Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 3European Medicines Agency Commences Review of CSL Behring's Regulatory Submission for rIX-FP for Hemophilia B Patients 2European Medicines Agency Commences Review of CSL Behring's Regulatory Submission for rIX-FP for Hemophilia B Patients 3European Medicines Agency Commences Review of CSL Behring's Regulatory Submission for rIX-FP for Hemophilia B Patients 4
Escherichia coli - For the qualitative detection of Escherichia coli 0157 and 0157:H7 in food products Accessories BinaxNOW EH E.coli 0157 & 0157:H7 Control Swab Pack (510-000) ...
Escherichia coli - For the qualitative detection of Escherichia coli 0157 and 0157:H7 in food products. Accessories BinaxNOW EH E.coli 0157 & 0157:H7 Control Swab Pack (510-000), BinaxNow E.coli...
For the qualitative detection of cardiac troponin I (cTnl) in human whole blood and serum specimens...
For the qualitative detection of antibodies to Treponema pallidum in human serum, plasma and whole blood specimens...
Medicine Products: